Navigation Links
Male fertility can be restored after cancer treatment, says Pitt team
Date:11/1/2012

PITTSBURGH, Nov. 1, 2012 An injection of banked sperm-producing stem cells can restore fertility to male primates who become sterile due to cancer drug side effects, according to researchers at the University of Pittsburgh School of Medicine and Magee-Womens Research Institute. In their animal study, which was published today in Cell Stem Cell, previously frozen stem cells restored production of sperm that successfully fertilized eggs to produce early embryos.

Some cancer drugs work by destroying rapidly dividing cells. As it is not possible to discriminate between cancer cells and other rapidly dividing cells in the body, the precursor cells involved in making sperm can be inadvertently wiped out leaving the patient infertile, said senior investigator Kyle Orwig, Ph.D., associate professor, Department of Obstetrics, Gynecology and Reproductive Medicine, Pitt School of Medicine, and an investigator at Magee-Womens Research Institute.

"Men can bank sperm before they have cancer treatment if they hope to have biological children later in their lives," he said. "But that is not an option for young boys who haven't gone through puberty, can't provide a sperm sample, and are many years away from thinking about having babies."

Even very young boys, though, have spermatogonial stem cells in their testicular tissue that are poised to begin producing sperm during puberty. To see whether it was possible to restore fertility using these cells, Dr. Orwig and his team biopsied the testes of prepubertal and adult male macaque monkeys and cryopreserved the cells from the small samples. The monkeys were then treated with chemotherapy agents known to impair fertility.

A few months after chemotherapy treatment, the team re-introduced each monkey's own spermatogonial stem cells back in to his testes using an ultrasound-guided technique. Sperm production was established from transplanted cells in nine out of 12 adult animals and three out of five prepuber
'/>"/>

Contact: Anita Srikameswaran
srikamav@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Stem cells show promise for treating infertility in cancer patients
2. Cell death discovery suggests new ways to protect female fertility
3. New ways to protect female fertility
4. Treating Sperm With Missing Protein Might Help Male Fertility
5. Ovarian Transplants May Preserve Fertility in Young Cancer Survivors
6. Fertility drug usage and cancer risk
7. Can Fertility Treatments Influence Later Breast Cancer Risk?
8. Fertility preservation with cryopreservation of ovarian tissue: from experimental to mainstream
9. Heavy Coffee Intake May Affect Fertility Treatments: Study
10. Childless women with fertility problems at higher risk of hospitalization for psychiatric disorders
11. Success of fertility treatment may approach natural birth rate
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... 25, 2014 When head lice hits a ... a frenzy to get rid of it while keeping it ... Coral Gables now have the solution right in their neighborhood: ... location, Lice Troopers provides full spectrum head lice screening and ... area, including Sunset, Key Biscayne, Brickell, Coconut Grove, Kendall, Pinecrest ...
(Date:12/25/2014)... The risk of burns from fires and cooking accidents ... extra cautious, an expert says. "Between Thanksgiving and ... patients coming in with burns," said Dr. Steven Sandoval, ... Center of Stony Brook University Hospital in New York. ... if not careful, could quickly turn tragic," Sandoval said ...
(Date:12/25/2014)... Dennis Thompson HealthDay Reporter ... could be closing in on a "fountain of youth" drug ... health of older adults, a new study suggests. Seniors ... a drug that targets a genetic signaling pathway linked to ... report. The experimental medication, a version of ...
(Date:12/25/2014)... 25, 2014 “ SmileStix ” was featured ... the latest and coolest mobile applications on the iOS, Android, ... host of NewsWatch, conducted the app review and shared with ... personal stickers. , The old saying goes, “A picture says ... words that can describe a single image, because each picture ...
(Date:12/25/2014)... 25, 2014 Each year trauma accounts ... million hospital admissions across the nation (according to ... CDC’s National Hospital Ambulatory Medical Care Survey ... conducted in 2010. They estimated that there were between ... in a primary diagnosis of broken bone or fracture. ...
Breaking Medicine News(10 mins):Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2Health News:Don't Let Burns Mar Your Holidays 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3Health News:An Application to Create Custom Stickers was Featured on NewsWatch Television on December 19, 2014 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 3Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 4
... 9 Genomma Lab Internacional, S.A.B. de C.V. ... leading Mexican over-the-counter ("OTC") pharmaceuticals and personal care products ... initiate the operation of a stock repurchase fund according ... Directors for an amount of up to Ps. 100 ...
... Nash Corporation (Nasdaq: KNSY ) today announced ... second quarter ended December 31, 2008 at 7:30 A.M. ... Kaufmann, President and CEO, will be hosting a teleconference ... at 9:00 A.M. Eastern Time. To participate in ...
... for immunized seniors, study found, , , FRIDAY, Jan. 9 (HealthDay ... every year could cut your risk of dying from flu ... isn,t always a perfect match for the strains circulating in ... Medicine study that included 10 flu seasons, worth of ...
... but they could signal later trouble , , FRIDAY, Jan. ... to worry about whether their disease might slow their ... function are accelerated among those with the blood sugar ... issue of Neuropsychology , scientists from the University ...
... Jan. 9 The New Combituck(TM) procedure brings the ... tummy tuck, or abdominoplasty, has been the only option ... after weight fluctuations or child birth. A new procedure, ... abdominal skin and fat layer, without the weeks off ...
... the Centers for Medicare and Medicaid Services (CMS) released ... national coverage determination (NCD). This proposed legislation would allow ... patients with all types of cancer. The proposed decision ... addition to initial diagnosis. Two important items in the ...
Cached Medicine News:Health News:Kensey Nash Corporation Announces Its Second Quarter 2009 Earnings Release Date and Teleconference 2Health News:You're Never Too Old for a Flu Shot 2Health News:You're Never Too Old for a Flu Shot 3Health News:Diabetes Linked to Cognitive Problems 2Health News:Doctors at Allure Medical Spa Are Getting the Results of a Tummy Tuck Without the Downtime 2Health News:SNM praises CMS decision to expand reimbursement for cancer treatment 2
(Date:12/24/2014)... Dec. 23, 2014  The American Diabetes Association ... target for people with diabetes and that all ... doses of statins, in keeping with recent changes ... the American College of Cardiology (ACC) and American ... the most recent changes to the Association,s annual ...
(Date:12/22/2014)... 22, 2014  CytoSorbents Corporation (OTCQB:CTSOD), a critical ... purification technology to help fight deadly inflammation in ... worldwide, today announced the appointment of Dr. ... its Senior Vice President of Clinical Development, effective ... Di Russo is an accomplished pediatric cardiothoracic ...
(Date:12/22/2014)... 2014 Research and Markets ( ... "Investment Analysis of the US Medical Device ... http://photos.prnewswire.com/prnh/20130307/600769 ... device sector identifies the key trends and rationale ... and mergers and acquisitions. The study ...
Breaking Medicine Technology:New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 3New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5Investment Analysis of the US Medical Device Sector 2
... BIRMINGHAM, Ala., Jan. 23 BioCryst,Pharmaceuticals, Inc. ... update on activities,conducted following release of the ... clinical development plan for intramuscular (i.m.) peramivir., ... Following release of preliminary Phase II results ...
... This Month ... at the University of Kentucky, LEXINGTON, Ky., ... on Aging are launching an Alzheimer,s,screening clinical trial with Neuronetrix,s ... assessments,using a technology called event-related potentials (ERP,s). The study is,expected ...
Cached Medicine Technology:BioCryst Updates Peramivir Clinical Development Plan 2BioCryst Updates Peramivir Clinical Development Plan 3BioCryst Updates Peramivir Clinical Development Plan 4BioCryst Updates Peramivir Clinical Development Plan 5BioCryst Updates Peramivir Clinical Development Plan 6Innovative Brain Scanning for Alzheimer's Screening Unveiled 2
... IMMULITE 2000 assays are ... the IMMULITE 2000, a ... immunoassay analyzer. IMMULITE 2000 ... centralization, and a rapidly ...
... CARDIAC M Myoglobin assay for use ... The Cardiac reader analyzer is a ... include: always ready to use (stand-by ... batch specific data entered automatically using ...
IRMA kit for detection of the cardiac marker Myoglobin...
... The CALBIOTECH INC. (CBI) Prolactin ELISA kit ... prolactin in human serum or plasma. Human ... polypeptide hormone with a molecular weight of ... based on a solid phase direct sandwich ...
Medicine Products: