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Male Contraception: Progress Slow but Steady
Date:4/12/2008

"The transient testicular warming [like sitting in a spa] causes the suppression to occur much earlier [than the hormones alone]," he said.
  • Transdermal gels -- In another study by Swerdloff's team, 140 men applied either a progestin gel called Nestorone or a testosterone gel, or both. The researchers studied various doses and then drew blood samples to measure hormone levels. They reported on the 119 men who complied and finished the study, concluding that the combination worked better to suppress sperm.
  • "Intra Vas Device," or IVD -- An alternative to a vasectomy, this method involves inserting silicone plugs into the vas deferens, the tube sperm move through and the same tube cut in a vasectomy. "The sperm can't get past the plugs," said Joe Hofmeister, president of Shepherd Medical Company in St. Paul, Minn., the IVD developer. "Preliminary six-month data show that 90 percent of 60 men [tracked to date] have zero motile sperm," he said. More study is needed to track the IVD for reversibility, Hofmeister said.
  • Vitamin A blocker -- Columbia University researchers tested a drug abandoned by a pharmaceutical company because it interferes with vitamin A receptors in the testes, lowering fertility. It worked well in animal studies; whether it will do the same in human studies is not yet known.

    • These approaches, if successful, will take several more years to get market approval, all the researchers agreed.

    More information

    To learn more about all available contraception methods, visit the U.S. National Library of Medicine.



    SOURCES: Ronald Swerdloff, M.D., professor of medicine, Harbor-UCLA Medical Center and David Geffen School of Medicine, University of California, Los Angeles, chief of the division of endocrinology, Harbor-UCLA Medical Center; Joe Hofmeister, p
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