Navigation Links
Malaria drug slows pancreatic cancer growth in mouse models
Date:3/15/2011

interest in cancer research, because they inhibit a process called autophagy (from the Greek for "self-eating") that is elevated in cancer cells.

Autophagy is present in normal cells as well, but at a much lower level. The process enables cells to break down and eliminate proteins, such as damaged cell membranes and worn-out organelles like mitochondria. But it is also a survival strategy. When nutrients are scarce, cells can digest and feed on their own non-critical proteins to avoid starvation.

Cancer cells also use autophagy to outwit chemotherapy treatment. Research has shown that cancer cells can activate this process in response to a variety of cancer treatments, allowing them to survive during the stress of therapy. But, as Kimmelman noted, autophagy can also be a cell-death mechanism. Cancer researchers are intensely studying and debating how to manipulate autophagy as a potential method to slow tumors' growth or make them more sensitive to other therapies.

In their research reported in Genes & Development, Kimmelman and colleagues were stunned to find that autophagy was turned on at all times in pancreatic cancer cell lines not just under conditions of stress, treatment or starvation. "This was a big surprise," he said. "These cells weren't deprived of nutrients; they were swimming in all the nutrients they could ever want." This suggested that for some unknown reason, pancreas tumors are highly dependent on autophagy, and therefore potentially uniquely good candidates for autophagy-inhibiting treatment.

In their next experiments, the team administered chloroquine to several different pancreatic cancer cell cultures, and also tested its effects in three types of mouse models. In the laboratory cultures, they reported, the drug "markedly decreased" the growth of the tumor cells, showing that the cells were heavily dependent on autophagy to for continued growth.

In vivo testing involved three types of mou
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Malarias weakest link
2. New study shows ability of transgenic fungi to combat malaria and other bug-borne diseases
3. MIT engineers design new nanoparticle that could lead to vaccines for HIV, malaria, other diseases
4. Saint Louis U scientists partner on malaria research
5. UIC researcher unveils new approach to blocking malaria transmission
6. Substandard and counterfeit antimalarial drugs discovered in Ghana
7. New Malaria Drug Proves Effective in Study of African Children
8. Major clinical trial prompts call for change to treatment guidelines for severe malaria worldwide
9. Mosquito Evolution May Make It Harder to Fight Malaria: Study
10. Malaria-transmitting mosquito evolving, NIH grantees find
11. Scientists pinpoint gene linked to drug resistance in malaria
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Malaria drug slows pancreatic cancer growth in mouse models
(Date:9/13/2014)... MillionaireSinglesDating.com is a millionaire dating ... niche dating services provider, which also launched the ... sugar daddy site , SugarDaddyMeet.com, and the leading ... has recently reached 2 million users milestone. , ... members include CEOs, lawyers, doctors, pro athletes, models ...
(Date:9/13/2014)... York (PRWEB) September 13, 2014 Stryker ... of the 2012 Rejuvenate and ABG II Modular-Neck Hip ... underway in New Jersey’s Bergen County Superior Court, Bernstein ... issued by the Court on September 10th, 2,097 cases ... increase of 33 filings since the Court issued its ...
(Date:9/13/2014)... Reinberg HealthDay Reporter SATURDAY, ... with Ebola who is being treated at a Nebraska medical ... Dr. Rick Sacra has been a patient in the hospital,s ... center on Sept. 5. On Friday, the hospital said ... pint of Ben & Jerry,s Chocolate Chip Cookie Dough, the ...
(Date:9/13/2014)... Fit Body Boot Camp is the fastest growing ... its reputation for intense, thirty-minute fat-burning workouts. Now Keith Stafford, ... is thrilled to announce the Opening of their fitness ... on opening a Fit Body Boot Camp location for over ... opening our doors.” , The Opening will be held at ...
(Date:9/13/2014)... 13, 2014 Top10BestSEOHosting.com is a ... compared a lot of web hosting suppliers and ... Arvixe are the best ASP.NET hosting suppliers in ... ASP.NET hosting is a very popular way for ... , The IT manager is happy to introduce ...
Breaking Medicine News(10 mins):Health News:MillionaireSinglesDating.com Reaches 2 Million Users Milestone 2Health News:Stryker Hip Lawsuit News: Rejuvenate and ABG II Hip Lawsuit Filings Near 2,100 in New Jersey Litigation, Bernstein Liebhard LLP Reports 2Health News:Stryker Hip Lawsuit News: Rejuvenate and ABG II Hip Lawsuit Filings Near 2,100 in New Jersey Litigation, Bernstein Liebhard LLP Reports 3Health News:American Ebola Patient Gets Appetite Back 2Health News:American Ebola Patient Gets Appetite Back 3Health News:Nashville Fit Body Boot Camp Announces Opening of New Fitness Boot Camp 2Health News:Nashville Fit Body Boot Camp Announces Opening of New Fitness Boot Camp 3Health News:Best ASP.NET Hosting Suppliers in 2014 Unveiled By Top10BestSEOHosting.com 2
... State-of-the-art, remote monitoring and clinician notification system helps ... nursing facility patients safe and clinicians happy, ... inventor of Pulse CO-Oximetry and,Measure-Through-Motion-and-Low-Perfusion pulse oximetry, today ... remote monitoring,and clinician notification system outside of a ...
... lens UV protection, SEATTLE, June 26 ... the fourth contact lens in the,ACUVUE(R) family of ... for,Ultraviolet Absorbing Contact Lenses from the American Optometric,Association,s ... Seattle at Optometry,s Meeting(TM), the annual meeting of ...
... announced the selection,of healthcare industry veteran Mary ... President of Business Development. An experienced leader ... Ms.,Bryngelson will focus on strategically linking the ... call center operations,compliance, and administration -- to ...
... in One of Canada,s Largest Academic Cancer Centers, ... ARAY ), a global leader in the ... l,Universite de Montreal (CHUM),has purchased a CyberKnife(R) Robotic ... in Montreal, Canada., CHUM, one of the ...
... for most wound types, PRINCETON, N.J., June ... provider of advanced wound care products,announced today that ... key,product line, MEDIHONEY(TM) Wound & Burn Dressings, this ... Leptospermum Honey packaged in a,tube, and a patented ...
... June 26 "The time is right and the,wording ... to,Life. "This bill recognizes the God-given Right to Life ... it will end the slaughter of,innocent children.", S.3111, ... co-sponsors,and is scheduled for debate in the Senate Committee ...
Cached Medicine News:Health News:First Nursing Facility Installation of Masimo Patient SafetyNet(TM) Goes Live With 'Remarkable' Results 2Health News:First Nursing Facility Installation of Masimo Patient SafetyNet(TM) Goes Live With 'Remarkable' Results 3Health News:First Nursing Facility Installation of Masimo Patient SafetyNet(TM) Goes Live With 'Remarkable' Results 4Health News:First Nursing Facility Installation of Masimo Patient SafetyNet(TM) Goes Live With 'Remarkable' Results 5Health News:American Optometric Association Awards Acuvue(R) Oasys(TM) for Astigmatism With Seal of Acceptance for UV Absorbing Contact Lenses 2Health News:American Optometric Association Awards Acuvue(R) Oasys(TM) for Astigmatism With Seal of Acceptance for UV Absorbing Contact Lenses 3Health News:ACM Adds Top Industry Executive to Its Leadership Team 2Health News:First CyberKnife System to be Installed in Canada 2Health News:First CyberKnife System to be Installed in Canada 3Health News:First CyberKnife System to be Installed in Canada 4Health News:Derma Sciences Launches Two New MEDIHONEY(TM) Formulations 2Health News:Derma Sciences Launches Two New MEDIHONEY(TM) Formulations 3
(Date:9/12/2014)... , Sept. 12, 2014 /PRNewswire-iReach/ -- 9 th ... 22-24, 2014 – Bethesda, MD ... http://www.fdanews.com/9thInspectionsSummitEarlyBird   Photo - http://photos.prnewswire.com/prnh/20140912/145652 ... for the next inspection than to get a glimpse ... during and after an inspection. Come to ...
(Date:9/12/2014)... DUBLIN , Sept. 12, 2014 ... addition of the "Global Medical Technologies Market ... Medical technology is a collective term for ... used to ensure good health. The Global Medical ... anaesthetic and respiratory technology, In vitro diagnostics technology, ...
(Date:9/12/2014)... 2014  Genomic Health, Inc. (Nasdaq: GHDX ... results from a health economic analysis suggesting that use ... in a significant reduction in direct medical costs and ... side effects of unnecessary treatment.  "By ... conventional measures, as demonstrated in this analysis, the Oncotype ...
Breaking Medicine Technology:FDAnews Announces: Early Bird Registration Discount Ends Sept.19 for 9th Annual Inspections Summit, Oct. 22-24, 2014 2FDAnews Announces: Early Bird Registration Discount Ends Sept.19 for 9th Annual Inspections Summit, Oct. 22-24, 2014 3Global Medical Technologies Market 2014-2018: Key Vendors are GE, Johnson & Johnson, Medtronic, Roche and Siemens 2Global Medical Technologies Market 2014-2018: Key Vendors are GE, Johnson & Johnson, Medtronic, Roche and Siemens 3Genomic Health Announces Publication of Colon Cancer Cost-Effectiveness Study in PharmacoEconomics 2Genomic Health Announces Publication of Colon Cancer Cost-Effectiveness Study in PharmacoEconomics 3Genomic Health Announces Publication of Colon Cancer Cost-Effectiveness Study in PharmacoEconomics 4Genomic Health Announces Publication of Colon Cancer Cost-Effectiveness Study in PharmacoEconomics 5
...
EDM Lumbar Drainage Kit with and without Bioglide are fabricated of radiopaque (barium impregnated) silicone tubing, and are packaged with stainless steel stylets inserted in the lumen....
... external ventricular drainage set (EVD ... fluid for external ventricular drainage. ... combination with a ventricular catheter ... 3XL probe from the Aesculap ...
... Bactiseal EVD Catheter system is ... catheter for external CSF drainage ... on catheter tube surfaces. Treated ... Impregnation Process, it reduces the ...
Medicine Products: