Navigation Links
Malaria drug slows pancreatic cancer growth in mouse models
Date:3/15/2011

BOSTON--Dana-Farber Cancer Institute scientists report they have shrunk or slowed the growth of notoriously resistant pancreatic tumors in mice, using a drug routinely prescribed for malaria and rheumatoid arthritis.

The pre-clinical results, which will appear in the April issue of the journal Genes & Development and is currently published on its web site, have already prompted the opening of a small clinical trial in patients with advanced pancreatic cancer, one of the deadliest and hardest-to-treat forms of cancer, said the investigators, led by Alec Kimmelman, MD, PhD, a radiation oncologist at Dana-Farber.

"We are seeing robust and impressive responses in pancreatic cancer mouse models," said Kimmelman, whose laboratory specializes in studies of pancreatic cancer, the fourth-leading cause of cancer death in the United States. The oral drug, hydroxychloroquine, is inexpensive, widely available, and causes relatively mild side effects, he said. A second, planned clinical trial will combine the drug with radiation.

"While these findings are indeed exciting and a cause for optimism, one needs to be mindful that so far the effects, while impressive, have only been shown in mice," said Ronald DePinho, MD, director of the Belfer Institute for Applied Cancer Science at Dana-Farber. "I eagerly await to see how the human studies will progress."

A new treatment avenue would be extremely welcome in pancreatic cancer. The National Cancer Institute estimates that 43,140 people were diagnosed in 2010 and 36,800 died. Despite some recent gains with targeted molecular agents and combination regimens, only about 6 percent of patients live five years, and the median survival is less than six months.

Hydroxychloroquine is a form of the drug chloroquine, which is used to prevent and treat malaria and also prescribed for autoimmune diseases, including lupus and rheumatoid arthritis. These compounds have recently stirred much
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Malarias weakest link
2. New study shows ability of transgenic fungi to combat malaria and other bug-borne diseases
3. MIT engineers design new nanoparticle that could lead to vaccines for HIV, malaria, other diseases
4. Saint Louis U scientists partner on malaria research
5. UIC researcher unveils new approach to blocking malaria transmission
6. Substandard and counterfeit antimalarial drugs discovered in Ghana
7. New Malaria Drug Proves Effective in Study of African Children
8. Major clinical trial prompts call for change to treatment guidelines for severe malaria worldwide
9. Mosquito Evolution May Make It Harder to Fight Malaria: Study
10. Malaria-transmitting mosquito evolving, NIH grantees find
11. Scientists pinpoint gene linked to drug resistance in malaria
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Malaria drug slows pancreatic cancer growth in mouse models
(Date:8/30/2014)... Acne is a common problem millions of American ... more than a daily nuisance, for some, it can have a ... can even lead to dramatic mood swings and depression. , ... clear up their skin. In some cases, that can make the ... and error, those on a quest for clearer skin can now ...
(Date:8/30/2014)... Market Research Report on Global and ... and in-depth market survey on Global and Chinese ... basic information of Cell Disruptor including its classification, ... global and China’s top manufacturers of Cell Disruptor ... market share etc. The report further analyzes quantitatively ...
(Date:8/30/2014)... Seniors Guide, the comprehensive guide to all things senior, has ... Dementia, and Memory Loss . , Country singer Glen Campbell, ... the Alzheimer’s, inspired Seniors Guide writers to review the trailer ... out on October 14, 2014, shows a glimpse of Glen ... – which inspires a final tour from the musician while ...
(Date:8/30/2014)... York, New York (PRWEB) August 30, 2014 ... other incretin mimetic claims continue to move forward in ... statement issued by AstraZeneca PLC on July 31, 2014, ... been named in 409 product liability claims that allege ... Court documents indicate that many of these claims are ...
(Date:8/30/2014)... Beach, Calif. (PRWEB) August 30, 2014 Insomnia ... Francis helps listeners understand how they unknowingly developed insomnia and ... have restful nights during. Tune in to the show ... The show airs live on August 30, and will ... more information on programming, go to DrCarolFrancisTalkRadio.com. , ...
Breaking Medicine News(10 mins):Health News:Acne Treatment Reviews Added to Popular Treatment Website 2Health News:Cell Disruptor Industry Global and Chinese Analysis for 2009-2019 in New Research Report at ReportsnReports.com 2Health News:Cell Disruptor Industry Global and Chinese Analysis for 2009-2019 in New Research Report at ReportsnReports.com 3Health News:Cell Disruptor Industry Global and Chinese Analysis for 2009-2019 in New Research Report at ReportsnReports.com 4Health News:Alzheimer’s Disease and Dementia Focus on Retirement Website SeniorsGuideOnline.com 2Health News:Byetta Lawsuits Move Forward, as Bernstein Liebhard LLP Notes Settlements in More than 80 Cases 2Health News:Byetta Lawsuits Move Forward, as Bernstein Liebhard LLP Notes Settlements in More than 80 Cases 3Health News:Sleepless Nights, Exhausting Days, Mental Fog – Relief for Insomnia With Clinical Psychologist Dr. Carol Francis 2
... fall after just a week away, study finds, , , MONDAY, ... from urban air pollution, children with mild persistent asthma begin ... A study in the March issue of Pediatrics ... children left the city for a rural area, airway inflammation ...
... GMPs and adverse event reportingWASHINGTON, March 2 ... Accountability Office (GAO) of a report on the ... Products Association (NPA) released the following statement from ... Association appreciates having the opportunity to be included ...
... Pa., March 2 As Pennsylvania Game Commission wildlife ... sites where bats have been confirmed infected or dying ... The sites are two abandoned mines near Carbondale, Lackawanna ... the abandoned Shindle Iron Mine, Aitkin Cave and Seawra ...
... Royalty Revenue Increases 72% from Prior YearDUBLIN, Calif., March ... a pharmaceutical company dedicated to the discovery and development ... the fourth quarter and year ended December 31, 2008. ... fourth quarter of $2.6 million, or $0.04 per share, ...
... 2 Align Technology, Inc. (Nasdaq: ... Invisalign Teen(TM) for non-adult, comprehensive orthodontic treatment. Invisalign ... demonstrated effectiveness of the Invisalign(R) system, with new ... permanent teeth, and root-movement control - issues that ...
... Hospitalist Company, Inc. (Nasdaq: IPCM ), a leading national ... quarter and full year ended December 31, 2008.Fourth Quarter 2008 Highlights: ... Net revenue increased 30% to $68.3 million for the ... Patient encounters increased 27% quarter-over-quarter ...
Cached Medicine News:Health News:City Kids Find the Breathin' Is Easier Elsewhere 2Health News:City Kids Find the Breathin' Is Easier Elsewhere 3Health News:Natural Products Association Comments on New GAO Report on Regulation of Dietary Supplements 2Health News:WNS Identified at Six Sites in Pennsylvania 2Health News:SuperGen Reports 2008 Fourth Quarter and Year-End Financial Results 2Health News:SuperGen Reports 2008 Fourth Quarter and Year-End Financial Results 3Health News:SuperGen Reports 2008 Fourth Quarter and Year-End Financial Results 4Health News:SuperGen Reports 2008 Fourth Quarter and Year-End Financial Results 5Health News:SuperGen Reports 2008 Fourth Quarter and Year-End Financial Results 6Health News:SuperGen Reports 2008 Fourth Quarter and Year-End Financial Results 7Health News:SuperGen Reports 2008 Fourth Quarter and Year-End Financial Results 8Health News:SuperGen Reports 2008 Fourth Quarter and Year-End Financial Results 9Health News:SuperGen Reports 2008 Fourth Quarter and Year-End Financial Results 10Health News:SuperGen Reports 2008 Fourth Quarter and Year-End Financial Results 11Health News:SuperGen Reports 2008 Fourth Quarter and Year-End Financial Results 12Health News:Align Technology Announces International Availability of Invisalign Teen(TM) 2Health News:Align Technology Announces International Availability of Invisalign Teen(TM) 3Health News:IPC The Hospitalist Company Reports Record Fourth Quarter and Full Year 2008 Results 2Health News:IPC The Hospitalist Company Reports Record Fourth Quarter and Full Year 2008 Results 3Health News:IPC The Hospitalist Company Reports Record Fourth Quarter and Full Year 2008 Results 4Health News:IPC The Hospitalist Company Reports Record Fourth Quarter and Full Year 2008 Results 5Health News:IPC The Hospitalist Company Reports Record Fourth Quarter and Full Year 2008 Results 6Health News:IPC The Hospitalist Company Reports Record Fourth Quarter and Full Year 2008 Results 7Health News:IPC The Hospitalist Company Reports Record Fourth Quarter and Full Year 2008 Results 8Health News:IPC The Hospitalist Company Reports Record Fourth Quarter and Full Year 2008 Results 9Health News:IPC The Hospitalist Company Reports Record Fourth Quarter and Full Year 2008 Results 10Health News:IPC The Hospitalist Company Reports Record Fourth Quarter and Full Year 2008 Results 11Health News:IPC The Hospitalist Company Reports Record Fourth Quarter and Full Year 2008 Results 12
(Date:8/30/2014)...   Royal Philips  (NYSE: PHG, AEX: PHIA) today ... ultrasound system designed to enable global hospitals and health ... and cost pressures. Making its debut at the  European ... Barcelona this week, Affiniti provides innovative technology ... resources deliver high quality patient care. ...
(Date:8/29/2014)... Aug. 29, 2014 /PRNewswire-iReach/ -- Market Research Report ... 2009-2019 is a professional and in-depth market survey ... industry . The report firstly reviews the basic ... application and manufacturing technology. The report then explores ... Scanner listing their product specification, capacity, Production value, ...
(Date:8/29/2014)... Aug. 29, 2014  Chuma Holdings, Inc. (OTCBB:CHUM) ... and turnkey support services for the lawfully organized ... processed and approved the Company,s name and symbol ... Corporation will be known as Chuma Holdings, Inc. ... through a merger with the Company,s wholly-owned subsidiary, ...
Breaking Medicine Technology:Philips Debuts New Affiniti Ultrasound System at the European Society of Cardiology Congress 2014 2Philips Debuts New Affiniti Ultrasound System at the European Society of Cardiology Congress 2014 3Philips Debuts New Affiniti Ultrasound System at the European Society of Cardiology Congress 2014 4X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 2X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 3X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 4X-Ray Crystallography Scanner Industry For Global and Chinese Market Forecast to 2019 5CannaMed Announces Name Change and Trading Symbol Change 2CannaMed Announces Name Change and Trading Symbol Change 3
... 8, 2011 Smith & Nephew (NYSE: ... its innovative, single-use DYONICS PLATINUM Series Shaver Blades which ... The removal of tissue, cartilage and bone ... The more precise and efficient surgeons are with their ...
... Sept. 8, 2011 Reportlinker.com announces that ... in its catalogue: Global ... http://www.reportlinker.com/p0611073/Global-Intravascular-Ultrasound-IVUS-Industry.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_I This report ... (IVUS) in US$ Million by the following ...
Cached Medicine Technology:Smith & Nephew's New DYONICS™ PLATINUM Series Shaver Blades Establish New Standard for Leading-edge Resection Performance 2Smith & Nephew's New DYONICS™ PLATINUM Series Shaver Blades Establish New Standard for Leading-edge Resection Performance 3Smith & Nephew's New DYONICS™ PLATINUM Series Shaver Blades Establish New Standard for Leading-edge Resection Performance 4Global Intravascular Ultrasound (IVUS) Industry 2Global Intravascular Ultrasound (IVUS) Industry 3Global Intravascular Ultrasound (IVUS) Industry 4Global Intravascular Ultrasound (IVUS) Industry 5Global Intravascular Ultrasound (IVUS) Industry 6Global Intravascular Ultrasound (IVUS) Industry 7Global Intravascular Ultrasound (IVUS) Industry 8Global Intravascular Ultrasound (IVUS) Industry 9Global Intravascular Ultrasound (IVUS) Industry 10Global Intravascular Ultrasound (IVUS) Industry 11Global Intravascular Ultrasound (IVUS) Industry 12Global Intravascular Ultrasound (IVUS) Industry 13
... The ACMI USA Series ACN-2 Flexible ... procedures. It is ideal for office practice. ... channel accommodates a full range of operating ... small outer diameter, and beveled, UltraGlide covered ...
These flexible stone retrieval devices are reusable, 3 Fr in diameter, with a working length of either 60 cm or 115 cm...
... Instrument System is a small power instrument ... modular and unitized handpieces., ,Electric Motor ... 1025 Power Console. Accepts all 1000 and ... hand throttle (#1000E) for use with foot ...
... Electric Micro Sagittal Saw, with ... deg. arc. Head rotates 360 ... angle, and our unique blade ... Can also be purchased without ...
Medicine Products: