Navigation Links
Malaria Drug Promising Against Cancer
Date:12/26/2007

60-year-old drug chloroquine eliminated certain malignancies in mice, researchers say

WEDNESDAY, Dec. 26 (HealthDay News) -- A common anti-malaria drug called chloroquine can also prevent the development of certain types of human cancers in mice, a U.S. study finds.

The finding may help lead to new kinds of cancer treatments, researchers say.

Scientists at The Scripps Institute and St. Jude's Children's Research Hospital found that chloroquine, which has been in use since 1946, blocked Burkitt lymphoma, a cancer of the lymphatic system, and ataxia telangiectasia (A-T), a rare immunodeficiency disease that predisposes people to cancer, especially leukemia and lymphoma.

The study was published online Dec. 20 by the Journal of Clinical Investigationand will appear in the January print edition.

"Our study shows that chloroquine inhibits the final steps of a pathway that is required for tumor cell survival and effectively eliminates cancer cells in mouse models that replicate human tumors," John Cleveland, chairman of the department of cancer biology at Scripps' campus in Jupiter, Fla., said in a prepared statement.

"The fact that the drug attacks premalignant cells, and cells that overexpress transcription factor MYC, a notorious contributor to tumorigenesis that is implicated in more than 70 percent of all cancers, makes the use of this drug very attractive for chemoprevention and cancer treatment," he said.

Much more research is required before these findings may lead to the development of new cancer drugs, he added.

More information

MedlinePlus has more about chloroquine.



-- Robert Preidt



SOURCE: Scripps Research Institute, news release, Dec. 20, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Kenyan malaria success strengthens call for free insecticide-treated nets for all
2. MDS Pharma Services Wins Award for Management of Global Malaria Trial
3. How adhesive protein causes malaria
4. Malaria product portfolio would benefit from greater cohesion amongst stakeholders
5. USAID Announces First Malaria Communities Program Grants
6. Collaborative Drug Discovery, Inc. and St. Jude Childrens Research Hospital Make Malaria Research Data Available to Speed Drug Development
7. World Bank Group Report on Malaria in Africa Highlights Progress Towards Goal of Significantly Reducing Malaria Deaths
8. Sanofi Pasteur and Institut Pasteur Team up Against Malaria
9. Bill and Melinda Gates Call for New Global Commitment to Chart a Course for Malaria Eradication
10. Malaria No More and Sumitomo Chemical Help Protect 1.4 Million Kids from Malaria
11. Malaria Vaccine Shows Promise
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... ... Mystic Buddha Publishing House presents Valentine’s Day tips on different forms and ... Dr. Frederick Lenz. , According to Publisher Roger Cantu, “Blue Skies Buddha ... and helping others. Valentine’s Day celebrates love in all its forms, and Blue ...
(Date:2/12/2016)... ... February 12, 2016 , ... ... — 1:30 p.m. – 3:00 p.m. EST, http://www.fdanews.com/fixeddosecombination ... cycle of pharmaceutical products, garnering increased attention from all stakeholders in the development ...
(Date:2/12/2016)... ... February 12, 2016 , ... The ... Zuckerberg San Francisco General Hospital on April 5-7. The series is a multi-day, ... new habits. The workshops cover a broad range of topics, including coaching skills, ...
(Date:2/12/2016)... ... 2016 , ... The Jones Agency, a family owned insurance company with offices ... cooperative charity drive with the Tarrant Area Food Bank in the hopes of alleviating ... in need, the Tarrant County Food Bank offers hope and security to the one ...
(Date:2/12/2016)... ... February 12, 2016 , ... Miami Dental Specialists is excited to bring ... dental office. Beginning in January, Miami Dental Specialists will offer the non-metal implants as ... first office to be chosen by the dental implant manufacturer, Straumann, to bring this ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... Stem cells are primitive cells found in ... the capacity to differentiate into mature cell types Stem ... first mouse embryonic stem cells were derived from embryos ... the first culturing of embryonic stem cells from non-human ... until 2006 As a result of these discoveries, stem ...
(Date:2/11/2016)... Feb. 11, 2016 Laboratory glassware ... in laboratories. These may range from microscope slides to ... is made from borosilicate glass because of its low ... the other hand, started gaining popularity over the past ... to replace glass with plastic in several applications due ...
(Date:2/11/2016)... 2016  Walgreens has committed to provide drug disposal ... Washington, D.C. as part of a program ... by shareholder advocacy organization As You Sow. Conrad ... people hold on to unneeded drugs because they lack easily ... --> Conrad MacKerron , Senior Vice President ...
Breaking Medicine Technology: