Navigation Links
Malaria Drug Promising Against Cancer
Date:12/26/2007

60-year-old drug chloroquine eliminated certain malignancies in mice, researchers say

WEDNESDAY, Dec. 26 (HealthDay News) -- A common anti-malaria drug called chloroquine can also prevent the development of certain types of human cancers in mice, a U.S. study finds.

The finding may help lead to new kinds of cancer treatments, researchers say.

Scientists at The Scripps Institute and St. Jude's Children's Research Hospital found that chloroquine, which has been in use since 1946, blocked Burkitt lymphoma, a cancer of the lymphatic system, and ataxia telangiectasia (A-T), a rare immunodeficiency disease that predisposes people to cancer, especially leukemia and lymphoma.

The study was published online Dec. 20 by the Journal of Clinical Investigationand will appear in the January print edition.

"Our study shows that chloroquine inhibits the final steps of a pathway that is required for tumor cell survival and effectively eliminates cancer cells in mouse models that replicate human tumors," John Cleveland, chairman of the department of cancer biology at Scripps' campus in Jupiter, Fla., said in a prepared statement.

"The fact that the drug attacks premalignant cells, and cells that overexpress transcription factor MYC, a notorious contributor to tumorigenesis that is implicated in more than 70 percent of all cancers, makes the use of this drug very attractive for chemoprevention and cancer treatment," he said.

Much more research is required before these findings may lead to the development of new cancer drugs, he added.

More information

MedlinePlus has more about chloroquine.



-- Robert Preidt



SOURCE: Scripps Research Institute, news release, Dec. 20, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Kenyan malaria success strengthens call for free insecticide-treated nets for all
2. MDS Pharma Services Wins Award for Management of Global Malaria Trial
3. How adhesive protein causes malaria
4. Malaria product portfolio would benefit from greater cohesion amongst stakeholders
5. USAID Announces First Malaria Communities Program Grants
6. Collaborative Drug Discovery, Inc. and St. Jude Childrens Research Hospital Make Malaria Research Data Available to Speed Drug Development
7. World Bank Group Report on Malaria in Africa Highlights Progress Towards Goal of Significantly Reducing Malaria Deaths
8. Sanofi Pasteur and Institut Pasteur Team up Against Malaria
9. Bill and Melinda Gates Call for New Global Commitment to Chart a Course for Malaria Eradication
10. Malaria No More and Sumitomo Chemical Help Protect 1.4 Million Kids from Malaria
11. Malaria Vaccine Shows Promise
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, ... Development, has been awarded a contract by the Center for Medicare and Medicaid ... to accelerate the enterprise use of Agile methodologies in a consistent and high ...
(Date:10/12/2017)... San Francisco, CA (PRWEB) , ... October 12, ... ... and Dr. Cheng, are now treating sleep apnea using cutting-edge Oventus ... sleep apnea, a serious sleep disorder characterized by frequent cessation in breathing. Oral ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) will ... during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual ... F. Collen, a pioneer in the field of medical informatics, this prestigious award is ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in healthcare ... Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during ... , The annual award competition recognizes editorial and design excellence across a range of ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... (HLA), the nation's first interactive health literacy software tool, and the Cancer Patient ... aspects of cancer patient education, today announce a new strategic alliance. , ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... 25, 2017   Montrium , an industry ... today—from the IQPC Trial Master Files & Inspection ... that EastHORN Clinical Services has selected eTMF ... TMF management. EastHORN, a leading European contract research ... increase transparency to enable greater collaboration with sponsors, ...
(Date:9/22/2017)... ROCKVILLE, Md. , Sept. 22, 2017  As ... by Republican Senators Bill Cassidy (R-LA) and ... Kalorama Information notes that the medical device industry is ... the medical device tax, the 2.3% excise tax on ... Act.  But they also want covered patients, increased visits ...
(Date:9/19/2017)... ZirMed Inc ., a recognized leader in cloud-based revenue cycle ... ranked #1 by its users for the seventh consecutive year ... ZirMed was recognized as the top-ranked end-to-end revenue cycle management ... 200 beds and holds one of the longest #1 ranking ... ...
Breaking Medicine Technology: