Navigation Links
Making cancer killers
Date:6/10/2010

A team of researchers has developed a method to produce cells that kill tumour cells in the lab and prevent tumours forming in mouse models of cancer. Although the current work is in cells and mouse, if the research transfers to human biology, the new type of cell could be a new source for cell-based anticancer therapies.

The cells were produced by knocking out a single gene essential in the pathways of development of immune cells: the modified cells become a novel type, which the authors call Induced T to Natural Killer Cells (ITNK cells).

Many cell types cooperate in the immune system to battle invaders, such as bacteria and viruses, and to remove abnormal or dead cells. T lymphocytes/T cells play an important part in defending against pathogens and abnormal self cells. They are thought also to play a role in autoimmune disease.

In this research, T cells were transformed into cells similar to another type, Natural Killer (NK) cells, which commonly act against viruses and cancer cells.

"We have been examining ways to produce clinically useful immune system cells," explains Peng Li, PhD student and first author on the publication, from the Wellcome Trust Sanger Institute. "We had shown that a gene called Bcl11b was essential for normal development of immune system cells - and of particular interest in the development of T cells.

"Here we can see the fruits of that work: we show, for the first time, that we can modify the developmental fate of immune system cells to produce a novel type that - if we can see the same effect in humans - could be of enormous value in cancer treatment."

The Bcl11b protein is a master switch that works by regulating the activity of other genes and it was known to be important in the immune system. However, this role in T lymphocyte development is entirely novel.

In the careful research, the team first showed that the Bcl11b gene was active only in T cells in the immune system and that its activity was needed at the earliest stages of production of T cells. When the team knocked out the Bcl11b gene, the mice produced no T cells.

"Remarkably, the mice lacking the Bcl11b gene produced a new type of immune system cell - the Induced T to Natural Killer cells," explains Dr Pentao Liu, senior author on the project from the Wellcome Trust Sanger Institute. "This is the first time we have seen these cells and the first time a gene regulator like Bcl11b has been shown to carry out such an important role in T cells.

"Even more important, we can see that these reprogrammed killer cells can attack cancer cells, whether in test tubes or in mouse models."

The ITNK cells killed melanoma and lymphoma cells in experiment in test tubes and were much more efficient than unmodified Natural Killer cells in the mouse and in human.

But they worked also on cancers. When tumour cells were injected into mice they produced at least tenfold fewer tumour foci in the Bcl11b-deficient than in Bcl11b-competent mice.

"The reprogrammed killer cells were effective in preventing metastasis - spread of the tumour in mice," explains Dr Francesco Colucci, from the University of Cambridge School of Clinical Medicine Dept of Obstetrics & Gynaecology. "The killing seems to be specific to the tumour cells and the normal cells seem to be spared.

"This is a really exciting development that could, if it can be transferred to humans, lead to development of new effective anticancer treatments. The results are stunning. One problem with cellular therapies is that one needs to produce large number of cells, something this work suggests could be done fairly easily with reprogrammed killer cells"

The team also looked at the effects of the cells in the medium term and showed that the ITNK cells continued to survive for at least three months.

The team also looked at the effects of the cells in the medium term and showed that the ITNK cells continued to survive for at least three months. Equally important, they could find no evidence of abnormality in the mice carrying ITNK cells. This suggests that ITNK cells do not indiscriminately kill normal cells or cause other damage, leading to optimism that ITNK cells might perform well in future therapies.


'/>"/>

Contact: Don Powell
don@sanger.ac.uk
44-122-349-6928
Wellcome Trust Sanger Institute
Source:Eurekalert

Related medicine news :

1. Dirty Hands Could be Making Australian Kids Ill
2. Is Your Corporate Job Making You Fat?
3. Grandpas Decision-Making Skills May Be Just Fine
4. Making Your Way Through the Fog of Chemotherapy
5. New On-Q Pain Pump Making Tummy Tucks Easier
6. Dr. Alexander Rivkin's Pioneering Non-Surgical Nose and Eye Transformations Are Making Headlines and May Be Permanent Solutions
7. Rent for Ryder Cup 2010: Making Your Stay Memorable
8. New Book Reveals the Powerful and Undermining Impact of Stress on Good Decision Making and What Leaders Can Do About It
9. Is patient coding making hospitals appear better than they are?
10. San Diego Plastic Surgery Practice Making a Splash in United Kingdom and Australia
11. Love Making And Exercise Can Trigger Headache Pain?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2017)... ... July 24, 2017 , ... A Southern California-based author has released a ... and how she has overcome them. “Forbidden Memories: A Memoir,” by author Michelle V. ... she has risen above. , In “Memories,” readers get a firsthand look at what ...
(Date:7/24/2017)... ... July 24, 2017 , ... Summer storms are inevitable as weather ... communities and often result in massive tree damage requiring emergency tree service. ... including tree trimming, tree cabling and hazardous tree removal. , “A summer ...
(Date:7/24/2017)... Province (PRWEB) , ... July 24, 2017 , ... ... Medicine's "Chinese Medicine Clinical Vitiligo Hospital" was set up, and the awarding ceremony ... of traditional Chinese medicine, the head of the army's health system, and national ...
(Date:7/24/2017)... ... ... “Nana Nana Boo Boo”: a delightful tale of a young girl who ... Boo” is the creation of published author Michael Rush, a Deputy Sheriff, former world ... Rush’s new book presents the importance of manners in a way easily understood by ...
(Date:7/24/2017)... ... , ... The Center for Addiction Recovery Training (CART), the ... second Multiple Pathways of Recovery Conference on October 23-26, 2017. This year, the ... foundational principle – a belief in multiple pathways of recovery, aims to bring ...
Breaking Medicine News(10 mins):
(Date:7/13/2017)... , July 13, 2017  Centurion Medical Products, a leader ... DisImpactor ® fecal impaction removal device for hospice patient care. ... Centurion ... Patient pain management and emotional ... Hospice can help alleviate patient pain while preventing unneeded emergency department ...
(Date:7/13/2017)... Md. , July 13, 2017  New York City-based ... of pharmaceutical markets should be aware of.  From new products ... trends are detailed in a recently completed study, Potential ... 1.  Age-Driven Growth ... we have been aware of the impact the growing population ...
(Date:7/12/2017)... , July 12, 2017  Eli Lilly and Company ... agreement with generic companies to resolve pending patent litigation in ... Virginia regarding the Cialis ® (tadalafil) ... on April 26, 2020. As part of the agreement, Cialis ... September 27, 2018. "The unit dose patent for ...
Breaking Medicine Technology: