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Making Obese Mice Slim, Without Diet or Exercise
Date:6/3/2009

ical activity.

"There are many different hormones and parts of the brain that are involved in regulating appetite, exercise and activity," Weiss said. "It's a concert and an orchestra. The goal is to be able to understand this system well enough to manipulate it so obesity and diabetes can be avoided."

Until then, watching what you eat and exercising remains the best means of staying slim, lowering blood glucose and preventing diabetes.

"Until we get a very clear understanding of the way that all of these compounds work together, we need to accept the fact that diet and exercise is the only well-proven, safe, side effect-free approach to weight and glucose control," Weiss said.

More information

The U.S. National Heart, Lung, and Blood Institute has more on overweight and obesity.



SOURCES: Christian Bjorbaek, Ph.D., associate professor, medicine, Harvard Medical School, Boston; Stuart Weiss, M.D., endocrinologist, New York University Langone Medical Center, and clinical assistant professor, endocrinology, New York University School of Medicine, New York City; June 2009, Cell Metabolism


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