Navigation Links
Major 'third-hand smoke' compound causes DNA damage -- and potentially cancer
Date:3/16/2014

DALLAS, March 16, 2014 Leftover cigarette smoke that clings to walls and furniture is a smelly nuisance, but now research suggests that it could pose a far more serious threat, especially to young children who put toys and other smoke-affected items into their mouths. Scientists reported today that one compound from this "third-hand smoke," which forms when second-hand smoke reacts with indoor air, damages DNA and sticks to it in a way that could potentially cause cancer.

Their talk was one of more than 10,000 presentations at the 247th National Meeting & Exposition of the American Chemical Society (ACS), the world's largest scientific society, taking place here through Thursday.

Bo Hang, Ph.D., who presented the research, said that although the idea of third-hand smoke made its debut in research circles just a few years ago in 2009, evidence already strongly suggests it could threaten human health.

"The best argument for instituting a ban on smoking indoors is actually third-hand smoke," said Hang, a scientist at Lawrence Berkeley National Laboratory (LBNL).

Researchers have found that many of the more than 4,000 compounds in second-hand smoke, which wafts through the air as a cigarette is smoked, can linger indoors long after a cigarette is stubbed out. Based on studies led by Hugo Destaillats, Ph.D., also at LBNL, these substances can go on to react with indoor pollutants such as ozone and nitrous acid, creating brand-new compounds, some of which may be carcinogenic.

One of those compounds goes by the acronym NNA. Hang's research has shown that NNA, a tobacco-specific nitrosamine, locks onto DNA to form a bulky adduct (a piece of DNA bound to a cancer-causing chemical), as well as other adducts, in lab test tubes. Other large compounds that attach to DNA tend to cause genetic mutations. NNA also breaks the DNA about as often as a related compound called NNK, which is a well-studied byproduct of nicotine and a known potent carcinogen. This kind of DNA damage can lead to uncontrolled cell growth and the formation of cancerous tumors.

Just as it took years to establish the cancer-causing effects of first-hand smoke that is inhaled as a person breathes in directly from the cigarette, making the connection between third-hand smoke or NNA and cancer could take a long time, Hang said. But early research into its nature, exposure and health effects is compelling enough that a research consortium dedicated to investigating third-hand smoke was formed in California in 2010. That consortium helped fund Hang's work on NNA-induced DNA damage, which he said could eventually be used as biomarkers to identify people who have been exposed to third-hand smoke.

The biggest potential health risk is for babies and toddlers, he noted. As they crawl and put their hands or toys in their mouths, they could touch, swallow or inhale compounds from third-hand smoke. Their small size and early developmental stage make them more vulnerable than adults to the effects of environmental hazards.

Although many public places prohibit smoking, Hang noted that people can still smoke in most rental apartments and private residences and smoking remains a huge public health issue. In 2011, nearly 44 million American adults reported smoking cigarettes, which ranks as the leading cause of preventable death in this country. And 34 million people smoke every day, according to data from the Centers for Disease Control & Prevention.

So far, the best way to get rid of third-hand smoke is by removing affected items, such as sofas and carpeting, as well as sealing and repainting walls, and sometimes even replacing contaminated wallboard, he explained. Replacing furniture can be pricey, but Hang said vacuuming and washing clothes, curtains and bedding can also help.


'/>"/>
Contact: Michael Bernstein
214-853-8005 (Dallas Press Center, March 14-19)
202-872-6042
m_bernstein@acs.org

Contact: Katie Cottingham, Ph.D.
214-853-8005 (Dallas Press Center, March 14-19)
301-775-8455
k_cottingham@acs.org

American Chemical Society


Source:Eurekalert

Related medicine news :

1. Patient requests for specific drugs have major impact on prescribing, reports study in Medical Care
2. Major League Baseball players win more games following Tommy John surgery
3. NYU researchers find majority of Latinas are unaware of their risk of diabetes
4. International study shows majority of children unaware of cigarette warning labels
5. Feasible, safe to limit radiation to major salivary glands in head and neck cancer patients
6. Merrill DataSite Releases New Comments: Majority of FDI Starting to Flow Into Emerging Markets
7. Out-of-pocket costs play major role in treatment adherence for cancer patients
8. Diminish Major Signs of Aging with the New Ageless Serum from Sublime Beauty®; Renovage® and Matrixyl® are Active Ingredients
9. Minority physicians care for a majority of underserved patients in the US
10. Small Business Majority -- 2013 Spells Year of Big Changes, Uncertainty for America’s Small Business Community
11. 2014 IMIA Conference Welcomes CyraCom as Its Major Sponsor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... ... August 22, 2017 , ... “Glimpses Of Light”: is a ... “Glimpses Of Light” is the creation of published author, J.M. Shepherd, a writer, teacher, ... answers to life’s perplexing mysteries. , Shepherd shares, “Love is one of the least ...
(Date:8/21/2017)... Louis, MO (PRWEB) , ... August 22, 2017 , ... ... career fairs to help healthcare employers connect with physicians and advanced practitioners like ... virtual career fairs in August through November of this year. The online ...
(Date:8/21/2017)... ... August 21, 2017 , ... SportsEngine, ... become the Official Technology Partner of North Country Region Volleyball and will power ... volleyball software, along with providing sport management software to their member clubs. ...
(Date:8/21/2017)... ... August 21, 2017 , ... PIXACORE , an independent full-service agency with ... 100 agencies of the year by MM&M. , This is the first time PIXACORE ... milestone for the agency. PIXACORE’s newfound recognition reflects its steady trajectory of growth ...
(Date:8/20/2017)... ... August 20, 2017 , ... A total solar eclipse will occur across ... minutes as the moon moves between the sun and Earth. This rare event will be ... tips can help keep you safe on the road during the total eclipse of the ...
Breaking Medicine News(10 mins):
(Date:8/3/2017)... DIEGO , Aug. 3, 2017  Opioid addiction ... diseases driving up healthcare costs and threatening outcomes, were ... lab supply and IVD industry that support them, met ... care market researcher said that drugs of abuse, procalcitonin ... and sessions at the organization,s 69th meeting in ...
(Date:8/2/2017)... Aug. 2, 2017  Life Flight Network and PeaceHealth Oregon ... improves patient care and operational efficiency for patients at hospitals ... , Cottage Grove , and ... PeaceHealth and Life Flight Network work collaboratively to move patients ... or when a time sensitive emergency exists. ...
(Date:7/31/2017)... , July 31, 2017  Diplomat Pharmacy, Inc. (NYSE: DPLO), ... Michigan by Crain,s Detroit Business ... and public companies by three-year revenue growth. This year,s edition ... To view the complete list, visit crainsdetroit.com/awards/fast_50/2017 ... is an incredible triumph," said Phil Hagerman , CEO ...
Breaking Medicine Technology: