Navigation Links
Major 'missed' biochemical pathway emerges as important in virtually all cells
Date:5/22/2008

DURHAM, N.C. -- A new study by Duke University researchers provides more evidence that the nitric oxide (NO) system in the life of a cell plays a key role in disease, and the findings point to ways to improve treatment of illnesses such as heart disease and cancer.

The nitric oxide system in cells is a major biological signaling pathway that has been missed with regard to the way it controls proteins, and it is linked to cancer and other diseases when the system goes awry, said Jonathan Stamler, M.D., a professor of medicine and biochemistry at Duke University Medical Center who worked on the study.

In the body, nitric oxide plays a role in the transport of oxygen to tissues and physiological activities such as the transmission of nerve impulses, and the beating of the heart. When things go awry with the nitric oxide system, bad things can happen in bodies, according to recent studies. For instance, there may be too little nitric oxide in atherosclerosis and there may be too much in Parkinsons disease; there may not be enough nitric oxide in sickle cell disease and there may be too much in some types of diabetes, Stamler said.

The new findings, which Stamler said change understanding of how the nitric oxide system is controlled, appear in the May 23 issue of the journal Science.

What we see now for the first time in the Science paper is that there are enzymes that are removing NO from proteins to control protein activity, Stamler said. This action has a broad-based effect, frankly, and probably happens in virtually all cells and across all protein classes. Nitric oxide is implicated in many disease processes. Sepsis, asthma, cystic fibrosis, Parkinsons disease, heart failure, malignant hyperthermia -- all of these diseases are linked to aberrant nitric-oxide-based signaling.

An important factor that previously wasnt appreciated, he said, is that the target of nitric oxide in disease is different in every case. The f
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. MedQuist to Get New Majority Stakeholder
2. US Air Force Medical Service Selects Shipcom Wireless for Major Healthcare RFID Contract
3. Majority of kidney cancers diagnosed at earliest stage
4. ACP says major system reforms needed to improve the state of primary care medicine in the US
5. Former Senate Majority Leader, Princeton Economist Joust on Future of Health Care
6. The German Embassy Would Like to Draw Your Attention to the Press Release of the University of Minnesota Center for German & European Studies to Present Major Healthcare Forum
7. Wyeths Pristiq, a New Treatment for Major Depressive Disorder in Adults, Now Available in U.S. Pharmacies
8. New Employment Practices Liability Policy from Beazley Offers Major Additional Benefits
9. First Major Chinese Medical Delegation Visits Minnesota
10. New Survey Finds Overwhelming Majority of Working Americans Not Financially Prepared for Disability, Would Rely on Sources Other than Themselves for Support
11. Video/Online Games For Health Come Of Age: Four Major Trends Now Emerging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... 2014 Ticket Down is a ... for her 2015 “Honeymoon Tour.” This well-known ticket exchange ... savings. , In early 2015, fans will have a chance ... across North America. Twenty-one-year-old Ariana Grande will hit the road ... her to 25 cities across the United States and Canada. ...
(Date:9/20/2014)... New York, New York (PRWEB) September 20, 2014 ... of power morcellators ( http://www.injurybeacon.com/power-morcellator/ ) in ... notes that yet another insurer has announced plans ... a statement posted on its website last month, ... such procedures effective November 1, 2014. The insurer ...
(Date:9/20/2014)... Recently, Best Cheap Hosting USA (best-cheap-hosting-usa.com), ... new website. The new site provides the latest ... for customers. Here, people can find a lot ... Also, it has recommended some excellent web hosting ... the great web hosting suppliers, InMotion ( http://www.best-cheap-hosting-usa.com/go/InMotion/ ...
(Date:9/20/2014)... dentists have advised their patients against drinking coffee and wine. ... that advice and changing his stance after considering two recent ... oral health. “There’s good news and great news,” says Dr. ... protecting against gum disease, and red wine can help fight ... the September 2014 issue of Boston University School of ...
(Date:9/20/2014)... September 20, 2014 Recently, UWDress.com, an ... and women’s special occasion outfits, has launched a special ... company’s prom outfits are popular among worldwide clients. Now, ... wholesale prom dresses on its website. , ... customers from around the world. Great custom made items ...
Breaking Medicine News(10 mins):Health News:Ariana Grande Tickets in New York, Philadelphia, Orlando, Fairfax, Worcester, Toronto, Uncasville, Detroit, Miami, Pittsburgh, Cleveland, and Atlanta On Sale Today 2Health News:Ariana Grande Tickets in New York, Philadelphia, Orlando, Fairfax, Worcester, Toronto, Uncasville, Detroit, Miami, Pittsburgh, Cleveland, and Atlanta On Sale Today 3Health News:As Power Morcellator Concerns Grow, Bernstein Liebhard LLP Notes Another Insurer’s Decision to Drop Coverage for Uterine Morcellation 2Health News:As Power Morcellator Concerns Grow, Bernstein Liebhard LLP Notes Another Insurer’s Decision to Drop Coverage for Uterine Morcellation 3Health News:Best Cheap Hosting USA Launches Its New Website And Recommends InMotion To Worldwide People 2Health News:South Charlotte Dentist, Dr. James Wells, is Changing His Advice on Coffee and Wine Drinking 2Health News:South Charlotte Dentist, Dr. James Wells, is Changing His Advice on Coffee and Wine Drinking 3Health News:Discounted 2014 Prom Dresses Provided By Innovative Company UWDress.com 2
... predictive tools, but not all agree , TUESDAY, Sept. 29 (HealthDay ... a milder interruption of blood flow to the brain, called a ... because of that, the researchers conclude, such an attack is ... implication of this study is that we cannot rely on the ...
... ... by a national nutrition company…A FREE 4 Week Personal Nutrition Plan guaranteed to ... ... boldest move ever constructed by a respected national nutrition company, Max Muscle Sports Nutrition ...
... ... (HFO) has added a new online continuing education (CE/CEU) course entitled ... nationally-approved CE courses for mental health professionals, nurses and allied healthcare ... that may occur close to death in a situation of physical ...
... ... Dr. Katz , ... (PRWEB) September 29, 2009 -- Foot pain and foot care come in all ... and ankle pain and are growing frustrated with continuous visits to their doctors. One physician, ...
... Organization (WHO) estimated that globally 400 million adults were obese, ... or greater. WHO projects that by 2015 there will ... is considered to be one of the greatest risk factors ... loss of joint cartilage. Researchers from Duke University, supported ...
... ... , ... 28, 2009 -- Keystone Mercy Health Plan , a member of the AmeriHealth ... members of the press to join Lt. General Russel Honoré , who is best known ...
Cached Medicine News:Health News:Mini-Stroke Found to Precede 1 in 8 Strokes 2Health News:Mini-Stroke Found to Precede 1 in 8 Strokes 3Health News:President Announces Free Health Plan 2Health News:President Announces Free Health Plan 3Health News:New Online Continuing Education Course on Near-Death Experience Added to HealthForumOnline's Library for Mental Health Professionals 2Health News:New Online Continuing Education Course on Near-Death Experience Added to HealthForumOnline's Library for Mental Health Professionals 3Health News:New Online Continuing Education Course on Near-Death Experience Added to HealthForumOnline's Library for Mental Health Professionals 4Health News:New Online Continuing Education Course on Near-Death Experience Added to HealthForumOnline's Library for Mental Health Professionals 5Health News:Dr. Marc Katz, Leading Podiatric Surgeon Adds High Powered Color Ultrasound To Cryosurgery Procedures and Treatments 2Health News:Study suggests obesity alone does not cause knee osteoarthritis in mice 2Health News:Katrina Hero, Lt. General Russel Honor (Ret.), to Speak on H1N1 Flu Preparedness at Press Briefing Following AmeriHealth Mercy/PerformRx Conference 2
(Date:9/19/2014)... Mass. , Sept. 19, 2014  Pressure ... today announced it has received and approved all ... HT48 instruments and has begun to manufacture the ... first instrument will be ready for shipment by ... built and released at a rate of about ...
(Date:9/19/2014)... 19, 2014  Over 200 runners participated in the ... the Radiation Oncology Institute (ROI), hosted by Radiation Business ... Park in San Francisco.  "Donations are ... of Radiation Business Solutions, "but at this point, ... $70,000 for the ROI this year. This surpasses last ...
(Date:9/19/2014)... PHILADELPHIA , Sept. 19, 2014  PCI ... Services International (Biotec).  Biotec is a leading provider ... Services headquartered in Bridgend, Wales ... .  The addition significantly expands PCI,s presence in ... medicinal products by adding packaging, storage and distribution ...
Breaking Medicine Technology:Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 2Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 3Fifth Annual 5K Run for the Future to Benefit the Radiation Oncology Institute Breaks Attendance, Donation Records 2Fifth Annual 5K Run for the Future to Benefit the Radiation Oncology Institute Breaks Attendance, Donation Records 3PCI Announces Acquisition Of Biotec 2PCI Announces Acquisition Of Biotec 3PCI Announces Acquisition Of Biotec 4PCI Announces Acquisition Of Biotec 5PCI Announces Acquisition Of Biotec 6
... - Strategic Collaboration with the Gynecologic Oncology Group ... Sciences, Inc. today,announced it has expanded its clinical ... 2 study of its lead product candidate,BSI-201. The ... inhibitor in the company,s DNA repair portfolio, for ...
... Updated Results Showing a 20% Reduction in the Risk, ... Disease Free Survival at ... Surgery -, BRIDGEWATER, N.J., May 28 Sanofi-aventis U.S.,announced ... supplemental new drug application (sNDA) to include six-year overall,survival analysis ...
Cached Medicine Technology:BiPar Sciences Expands Clinical Development of BSI-201, A Novel PARP Inhibitor, With Phase 2 Trial in Uterine Cancer 2New Eloxatin(R) (oxaliplatin injection) Prescribing Information in the U.S. Includes Six-Year Overall Survival Data 2New Eloxatin(R) (oxaliplatin injection) Prescribing Information in the U.S. Includes Six-Year Overall Survival Data 3New Eloxatin(R) (oxaliplatin injection) Prescribing Information in the U.S. Includes Six-Year Overall Survival Data 4
Double-ended. Designated most popular model or size....
Double-ended. Sharp and blunt 6.5 mm tips. Designated most popular model or size....
2 mm tip....
Octagonal handle. 3 mm wide....
Medicine Products: