Navigation Links
Major grant awarded for HIV prevention study in Africa

A team of researchers led by Professor Richard Hayes at the London School of Hygiene & Tropical Medicine has been awarded $37 million to test an innovative combination of strategies to prevent HIV in African countries.

The project, called Population ART (PopART), will test the impact of a combination prevention strategy that combines community-wide house-to-house voluntary testing for HIV, offer of medical circumcision to men who test HIV-negative, and offer of immediate initiation of antiretroviral therapy (ART) for all those testing HIV-positive.

Researchers from LSHTM and partners including Imperial College London, the Zambia AIDS Related Tuberculosis Project (ZAMBART) and the Desmond Tutu TB Centre (DTTC), Stellenbosch University, South Africa will work closely on this trial with colleagues from the HIV Prevention Trials Network (HPTN).

Part of the HPTN, the study (designated HPTN 071) has been funded jointly by organisations including the National Institute of Allergy and Infectious Diseases (NIAID),the National Institute of Mental Health (NIMH), the Office of the United States Global AIDS Coordinator (OGAC) and the Bill and Melinda Gates Foundation (BMGF).

An estimated 33 million people worldwide are living with HIV; with 2.5 new infections for every HIV-positive patient commencing ART, current approaches to treatment and prevention are struggling to contain the spread of the infection.

Unless the incidence of HIV can be steeply reduced, forecasts show a continuously growing number of HIV-infected individuals so that by 2030 about $35 billion per year will be needed to deliver ART to HIV-positive patients in these resource-limited settings.

Combination prevention approaches like PopART may be initially more expensive than current approaches, but estimates suggest that if HIV incidence is not reduced significantly, the financial impact of an ever increasing number of patients in need of treatment and hospitalisation will be far greater.

The new project builds on two previous HPTN trials. Project Accept (HPTN 043) found that adding community mobilization and support services to a mobile HIV counselling and testing programme can improve rates of testing in rural communities. HPTN 052 was the first randomized trial to show that treating an HIV-infected individual with ART reduces the risk of sexual transmission of HIV to an uninfected partner.

Mathematical modelling has shown that the PopART intervention should lead to a steep reduction in new HIV infections. A rigorously designed trial is now needed to test whether such interventions can be effectively implemented in resource-poor settings in Africa, and to measure the actual impact on HIV at population level.

Starting in 2012, the trial will be carried out in 24 communities in Zambia and South Africa, with a total population of over 1 million. Eight communities will receive the full PopART intervention while eight control communities will receive current standard of care. The remaining eight communities will receive an intermediate intervention which includes all the components of PopART except that ART will be given according to current national guidelines. This three-arm design will allow the trial to measure the extra effect of treating patients immediately rather than waiting until their immune function has deteriorated. A total of 60,000 adults from the communities will be followed up for 2 years to measure the impact of the interventions on new HIV infections.

Data from the trial will be combined with cost data and projections from mathematical models to estimate the cost effectiveness of the intervention and alternative approaches.

Richard Hayes, Professor of Epidemiology and International Health at LSHTM, says: "PopART is designed as a universal intervention offered to the entire community. We hope this will prevent stigmatisation of infected individuals and reduce the need for specially targeted interventions for specific risk groups. There is a strong rationale for the PopART approach, but we need a rigorously conducted study to determine how well the strategy can be delivered in practice, and what impact it has at population level."

Professor Peter Piot, the School's Director and former Executive Director of UNAIDS, says: "I am delighted that this award has been made as it will enable the promising idea of combination prevention strategy to be tested on a large scale. This is one of the most important questions for AIDS research and policy today."


Contact: Paula Fentiman
London School of Hygiene & Tropical Medicine

Related medicine news :

1. One Month after Major Quake, Ongoing Crises for Haitian Children
2. Virginia House Majority Leader Morgan Griffith Sponsors Legislation Enabling Mobile Solution for Health Care SALEM, Va.
3. Major milestone achieved by our joint venture in China
4. Sunquest Announces Major Software Updates and Enhancements
5. MIT China joint venture is preparing a major commercial launch in July 2010
6. Majority of Americans Approve of President Obamas Handling of Afghanistan and National Security But Disapprove of Handling of Economic Issues, Per Franklin & Marshall College Poll With Hearst Television
7. Highlights of major physics conference in Washington, D.C.
8. The Icebox of Atlanta Selected as T-shirt Vendor for 3 Major Divisions of American Cancer Society's Relay For Life
9. Majority of Marylanders without advance medical directives
10. Pew Report Finds Majority of States Fail to Ensure Proper Dental Health & Access to Care for Children
11. Americans Remain Split on Stalled Health Care Legislation, but Some Provisions Popular Among Majorities of Democrats, Independents and Republicans
Post Your Comments:
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... , ... June 25, 2016 , ... "With 30 hand-drawn ... specific project," said Christina Austin - CEO of Pixel Film Studios. , ProHand ... all within Final Cut Pro X . Simply select a ProHand generator and ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
(Date:6/24/2016)... , ... June 24, 2016 , ... A recent ... most people are unfamiliar with. The article goes on to state that individuals are ... many of these less common operations such as calf and cheek reduction. The Los ...
(Date:6/24/2016)... ... 2016 , ... Marcy was in a crisis. Her son James, eight, was out of control. ... and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... rocks at my other children and say he was going to kill them. If ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016  Collagen Matrix, Inc., ("Collagen Matrix") the ... of collagen and mineral based medical devices for ... Bill Messer has joined the company as ... the growing portfolio of oral surgery, neurosurgery, orthopaedic ... joins the Collagen Matrix executive team as an ...
(Date:6/24/2016)... CAMBRIDGE, Mass. , June 24, 2016 /PRNewswire/ ... the Spaulding Rehabilitation Network,s Dean Center for ... of Physical Medicine and Rehabilitation, MIT Hacking Medicine, ... Center for Innovation, today announced the five finalists ... Hackathon for Lyme disease.  More than 100 scientists, ...
(Date:6/24/2016)... 2016 Research and Markets ... Electronics 2015-2025: Applications, Technologies, Forecasts" report to ... In-Mold Electronics, Smart Skin, Structural Health Monitoring, Composite ... Structural electronics involves electronic and/or electrical components and ... dumb structures such as vehicle bodies or conformally ...
Breaking Medicine Technology: