Navigation Links
Major cause of chronic kidney disease-related inflammation is identified
Date:12/13/2011

Irvine, Calif., Dec. 13, 2011 UC Irvine researchers have uncovered an important source of inflammation seen in people with chronic kidney disease, which is increasingly common due to the epidemic of obesity-related diabetes and hypertension.

Dr. N.D. Vaziri, professor emeritus of medicine and physiology & biophysics, found that CKD causes massive depletion of the key adhesive proteins, called the tight junction, that normally seal the space between the cells lining the intestines. This breakdown in the colon allows the leakage of microbial products and other noxious material into the body's internal environment, accounting for the persistent systemic inflammation that frequently occurs in CKD patients.

"In fact, low levels of bacterial endotoxins are often noted in the blood of individuals with advanced chronic kidney disease," Vaziri said. "However, the source and place of entry of these toxins were previously unknown."

Understanding the connection between CKD and tight junction disintegration, he added, could lead to novel treatments to curb this inflammation and its many adverse consequences. Study results appear online in the journal Nephrology Dialysis Transplantation.

It's estimated that nearly 25 million people in the U.S. have CKD, and more than 400,000 have end-stage kidney disease requiring dialysis. Many CKD patients develop accelerated cardiovascular disease the primary cause of premature death in this population linked to persistent inflammation.

"The relentless inflammation seen in chronic kidney disease has devastating effects on the cardiovascular system and other parts of the body," Vaziri said.

Intestinal microbes produce various compounds that, outside the gastrointestinal tract, can provoke inflammation without infection. The intestines normally prevent microbes, noxious microbial byproducts and other harmful material from entering the body's internal environment. Key to this containment are the cells lining the digestive system and a complex set of adhesive proteins that seal the space between them, much like grout between tiles.

Vaziri and his team are currently exploring therapeutic interventions to limit disintegration of this barrier and, consequently, inflammation in CKD patients.


'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Related medicine news :

1. Brain tsunamis are clue to helping victims of major head injuries
2. Northern Ireland company makes major breakthrough in cancer treatment
3. Major project to implement new treatments to boost kala-azar elimination strategies
4. Earthquakes Put Millions of Lives, Major Cities at Risk
5. How major signaling pathways are wired to our genome gives new insight into disease processes
6. Policymakers should prepare for major uncertainties with Medicaid expansion
7. Ghost Writing Persists in Major Medical Journals
8. Teenage girls and senior students suffered highest levels of PTSD after major earthquake
9. Harvard Medical School launches major initiative to address crisis in drug development
10. Alcohol, Obesity Major Causes of Sudden Heart Death
11. Prevention measures needed to address major risk of falls after stroke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary ... Dallas that it will receive two significant new grants to support its work ... marked its 25th anniversary by recognizing patients, medical professionals and scientists for their ...
(Date:6/24/2016)... ... ... BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a ... an hour by 2020 and then adjusting it yearly to increase at the same rate ... assure the wage floor does not erode again, and make future increases more predictable. , ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & Innovative Solutions today ... cultivation and processing operations at its production facility, and opened its first two ... the manufacturer of a complete system of proactive air and surface purification solutions ...
(Date:6/24/2016)... ... June 24, 2016 , ... Today, MTI-GlobalStem, a provider ... and other difficult to transfect cells, announces its launch of the PluriQ™ G9™ ... Editing System is a complete system for culturing and transfecting human pluripotent ...
(Date:6/24/2016)... ... June 24, 2016 , ... Southern Illinois University ... co-chairs for the Illinois State Dental Society (ISDS) Foundation’s Mission of Mercy (MOM). ... Convention Center in Collinsville. , They expect to treat approximately 2,000 ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Research and Markets has announced the ... Tests" report to their offering. ... The World Market for Companion Diagnostics covers the ... analysis in the report includes the following: ... Kits) by Region (N. America, EU, ROW), 2015-2020 , ...
(Date:6/23/2016)... 23, 2016  MedSource announced today that it ... software solution of choice.  This latest decision demonstrates ... to their clients by offering a state-of-the-art electronic ... establishes nowEDC as the EDC platform of choice ... clients.  "nowEDC has long been a preferred EDC ...
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... BRAHMS PCT (procalcitonin) assay as a dedicated testing solution ... this clearance, Roche is the first IVD company in ... sepsis risk assessment and management. PCT is ... levels in blood can aid clinicians in assessing the ...
Breaking Medicine Technology: