Navigation Links
Major cause of chronic kidney disease-related inflammation is identified
Date:12/13/2011

Irvine, Calif., Dec. 13, 2011 UC Irvine researchers have uncovered an important source of inflammation seen in people with chronic kidney disease, which is increasingly common due to the epidemic of obesity-related diabetes and hypertension.

Dr. N.D. Vaziri, professor emeritus of medicine and physiology & biophysics, found that CKD causes massive depletion of the key adhesive proteins, called the tight junction, that normally seal the space between the cells lining the intestines. This breakdown in the colon allows the leakage of microbial products and other noxious material into the body's internal environment, accounting for the persistent systemic inflammation that frequently occurs in CKD patients.

"In fact, low levels of bacterial endotoxins are often noted in the blood of individuals with advanced chronic kidney disease," Vaziri said. "However, the source and place of entry of these toxins were previously unknown."

Understanding the connection between CKD and tight junction disintegration, he added, could lead to novel treatments to curb this inflammation and its many adverse consequences. Study results appear online in the journal Nephrology Dialysis Transplantation.

It's estimated that nearly 25 million people in the U.S. have CKD, and more than 400,000 have end-stage kidney disease requiring dialysis. Many CKD patients develop accelerated cardiovascular disease the primary cause of premature death in this population linked to persistent inflammation.

"The relentless inflammation seen in chronic kidney disease has devastating effects on the cardiovascular system and other parts of the body," Vaziri said.

Intestinal microbes produce various compounds that, outside the gastrointestinal tract, can provoke inflammation without infection. The intestines normally prevent microbes, noxious microbial byproducts and other harmful material from entering the body's internal environment. Key to this containment are the cells lining the digestive system and a complex set of adhesive proteins that seal the space between them, much like grout between tiles.

Vaziri and his team are currently exploring therapeutic interventions to limit disintegration of this barrier and, consequently, inflammation in CKD patients.


'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Related medicine news :

1. Brain tsunamis are clue to helping victims of major head injuries
2. Northern Ireland company makes major breakthrough in cancer treatment
3. Major project to implement new treatments to boost kala-azar elimination strategies
4. Earthquakes Put Millions of Lives, Major Cities at Risk
5. How major signaling pathways are wired to our genome gives new insight into disease processes
6. Policymakers should prepare for major uncertainties with Medicaid expansion
7. Ghost Writing Persists in Major Medical Journals
8. Teenage girls and senior students suffered highest levels of PTSD after major earthquake
9. Harvard Medical School launches major initiative to address crisis in drug development
10. Alcohol, Obesity Major Causes of Sudden Heart Death
11. Prevention measures needed to address major risk of falls after stroke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2016)... ... December 04, 2016 , ... Patients who ... now take advantage of a cosmetic procedure known as Carbon Dioxide (C02) ... the appearance of age spots, fine lines, uneven coloration, wrinkles, scarring, skin ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... Halfway through ... Medicine has provided preventative dental services to more than 15,900 children 5 years old ... 5 LA pledged $38 million over a span of five years to Western University ...
(Date:12/2/2016)... ... 02, 2016 , ... On Dec. 2, 2016, CURE® magazine will host the ... the 2016 MPN Heroes—eight individuals who have made a difference in the field of ... standard of care, demonstrating leadership within the MPN community and/or a commitment to individual ...
(Date:12/2/2016)... ... ... Advanced Inc., a leading provider of travel therapy and travel nursing across ... Advanced Inc.’s Chief Financial Officer, effective December 1, 2016. Jason previously served as Vice ... leadership experience to Advanced Inc. He began his career in finance at Ernst & ...
(Date:12/2/2016)... ... , ... The annual time frame to change Medicare health and prescription drug ... 7th. Currently-enrolled Medicare beneficiaries who are looking to switch from their current plan to ... make changes during this period order for their new policy to go into effect ...
Breaking Medicine News(10 mins):
(Date:12/4/2016)... Dec. 3, 2016 Johnson & Weaver, LLP announces ... purchasers of Zimmer Biomet Holdings, Inc. (NYSE: ZBH ... October 31, 2016 (the "Class Period"). Zimmer Biomet ... markets orthopaedic reconstructive products, such as knee and hip reconstructive ... , , ...
(Date:12/4/2016)... highly innovative, personalized cell-based treatment for a high-risk form of the most ... Children,s Hospital of Philadelphia today reported new results ... The physician-scientists presented findings at the annual meeting of the ... Continue Reading ... ...
(Date:12/2/2016)... -- bioLytical Laboratories, un líder mundial en test rápidos de enfermedades ... Test , a los miembros de la Kenya Pharmaceutical Association. ... ... HIV Self Test! (PRNewsFoto/bioLytical Laboratories) ... http://photos.prnewswire.com/prnh/20161201/444905 ) bioLytical fue invitada por la Clinton Health ...
Breaking Medicine Technology: