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Major Imaging Initiative to Shed Light on Little Known Brain Disease
Date:1/25/2010

lower the cost of clinical trials and make it possible for more patients to enroll because MRI scanners are commonly available.”

The study will investigate whether a combination of images, such as structural MRI, PET and DTI, will provide a better explanation of how a patient is doing than any one of these image types alone. It also will include serial assessments of the chemistry in the blood and cerebrospinal fluid the surrounds the brain, to see how these relate to changes in the brain images.

The new study, known as the Frontotemporal Lobar Degeneration Neuroimaging Initiative, takes advantage of the infrastructure developed for another major NIH-funded study of which UCSF is a leader, known as the Alzheimer’s Disease Neuroimaging Initiative, says Rosen.

The ADNI, begun in 2004, established procedures that make it possible to obtain comparable images at different centers, and has established procedures for ensuring high quality data. This year, the ADNI made a significant step forward in developing a test to help diagnose the beginning stages of Alzheimer’s disease sooner and more accurately by measuring levels of two biomarkers -- tau and beta-amyloid proteins -- in cerebrospinal fluid.

The FTLDNI is funded primarily by the National Institute of Aging, and is co-funded by the National Institute of Neurological Disease and Stroke.

Related links:

UCSF Memory and Aging Center – spotlight on FTD
http://memory.ucsf.edu/ftd/

UCSF Memory and Aging Center
http://memory.ucsf.edu/

Contact:
Corinna Kaarlela, News Director
Source: Jennifer O’Brien (415) 476-2557
Web: www.ucsf.edu <
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