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Major HIV prevention trial in women to drop oral tenofovir arm
Date:9/28/2011

erns, and the DSMB recommended each time that the study continue, without changes. The next routine review of VOICE data by the DSMB will take place in mid-November of this year. This will be the sixth routine review and the third interim efficacy analysis of VOICE.

Globally, women account for 60 percent of adults with HIV in sub-Saharan Africa, where unprotected heterosexual intercourse is the primary driver of the epidemic. Young women are especially vulnerable. In southern Africa, young women are up to five times more likely to become infected with HIV than young men, and more than a quarter (26 percent) of all new global HIV infections occur in women aged 15-24. Women are twice as likely as their male partners to acquire HIV during sex. Although correct and consistent use of male condoms has been shown to prevent HIV, women are not always able to negotiate their use. Women desperately need methods for preventing HIV that they can control themselves. ARV-based prevention methods as either a vaginal gel or an oral tablet are promising approaches.

Oral tenofovir (tenofovir disoproxil fumarate), known by the brand name Viread , and Truvada, a combination tablet that contains tenofovir and emtricitabine, are both approved for the treatment of HIV when used in combination with other ARVs. Viread and Truvada are registered trademarks of Gilead Sciences, Inc., of Foster City, Calif., U.S. Both have been evaluated in clinical trials in different at-risk populations to determine if they can prevent HIV in people who are HIV-negative. Besides VOICE, only one other PrEP effectiveness trial is currently ongoing. The U.S. Centers for Disease Control and Prevention is testing the effectiveness of oral tenofovir taken daily for reducing the risk of HIV among 2,400 injection drug users in Thailand. Results are anticipated in 2012.

Tenofovir gel is a vaginal microbicide that contains the same active ingredient as the oral tablet formulation of tenofo
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Contact: Lisa Rossi
rossil@upmc.edu
412-916-3315
Microbicide Trials Network
Source:Eurekalert

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