Navigation Links
Maintaining immune balance involves an unconventional mechanism of T cell regulation
Date:7/3/2013

sulted in dramatically reduced immune suppression by regulatory T cells and the mice rapidly developed a fatal inflammatory disorder.

Researchers also showed that mTORC1 works by integrating signals from two immune receptors on the cell surface with cholesterol metabolism. With the right input, mTORC1 promoted production of regulatory T cells and cemented their role as suppressors of immune activity.

In another twist, investigators linked that suppressive function to cholesterol and lipid metabolism. Rather than relying on more conventional strategies of immune regulation, researchers showed how regulatory T cells depend on the metabolic pathway to control production of molecules CTLA4 and ICOS, which are responsible for immune suppression. Production of CTLA4 and ICOS by regulatory T cells decreased as lipid metabolism dropped. "We are just starting to appreciate the importance of lipids in the immune system, particularly in the function of regulatory T cells," Chi said.


'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Clemson researchers collect and reuse enzymes while maintaining bioactivity
2. Penn-Temple team discovers gatekeeper for maintaining health of cell energy source
3. Federal government renews contract for collecting and maintaining national stem cell transplantation database
4. Maintaining weight loss as important as losing it for older women
5. RI Hospital: Radiation can be reduced while maintaining high quality in CT colonography
6. AIG study shows hospital C-Suite and Risk Managers struggle with maintaining patient safety
7. Research Shows Non-Chain Restaurants Serve Excessive Calorie Meals, Making Appetite Suppressants Like Liproxenol Helpful With Maintaining Portion Control
8. Daimer Unveils Carpet Cleaner For Maintaining Health Clubs
9. Hearst Tower Window Washers Pulled To Safety After Scaffold Buckles; Construction Injury Lawyers Block O'Toole & Murphy, LLP Call For Maintaining Worker Safety Laws
10. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Offer Patients Fast Weight Loss With New hCG Diets, Easily Maintaining Weight In the Future With Healthy Eating
11. How does the immune system fight off threats to the brain? New research yields fresh insight
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... October 22, 2014 Richard Carlson, Managing ... industry leader with over 25 years experience. Mr. ... in the areas related to EDI, B2B Commerce, RFID ... an Editorial Advisory Board member for Pharmaceutical Commerce Magazine ... Blue Fin Group is a management and technology consulting ...
(Date:10/22/2014)... Maureen Salamon HealthDay Reporter ... undergoing in vitro fertilization (IVF) are only about half as ... assisted reproduction technique, new research indicates, and the racial disparity ... study, about 31 percent of white patients became pregnant after ... Analyzing more than 4,000 IVF cycles over two years to ...
(Date:10/22/2014)... Maureen Salamon HealthDay ... A crucial part of conventional in vitro fertilization (IVF) -- ... instead take place in a device inside the vagina, new ... contend that the device, called an INVOcell, might sharply cut ... also make the technology more accessible to those who don,t ...
(Date:10/22/2014)... Dennis Thompson HealthDay Reporter ... who was diagnosed with Ebola while working for NBC News ... can leave the special isolation unit at Nebraska Medical Center in ... the hospital said Tuesday. A blood test confirmed by the ... 33, can head home to Providence, R.I., NBC News ...
(Date:10/20/2014)... Allegheny General Hospital’s (AGH) Cardiovascular Institute is offering ... a damaged mitral valve as the heart continues to ... Abbott Vascular , is designed to treat degenerative ... which the heart’s mitral valve leaflets fail to close ... left ventricle into the left atrium. The heart must ...
Breaking Medicine News(10 mins):Health News:Rich Carlson and Marc Duey to Hold Workshop at CBI’s Specialty Pharmacy and Distribution Networks Conference 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 3Health News:Experimental Infertility Treatment Seems Effective, Cheaper 2Health News:Experimental Infertility Treatment Seems Effective, Cheaper 3Health News:Experimental Infertility Treatment Seems Effective, Cheaper 4Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 3Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3
... for women than men, major study finds , MONDAY, Aug. ... significantly increased risk for head and neck cancers such as ... and throat, says a U.S. National Cancer Institute study that ... women between 1995 and 2000. , The analysis revealed that ...
... the market in 2004 because they caused dangerous heart problems ... Hla at the University of Connecticut, may now have figured ... study will be published online in the The Journal of ... these drugs is an enzyme called COX-2, which is produced ...
... Smoking significantly increases the risk for head and neck ... anatomic site. Published in the October 1, 2007 issue ... Society, a large, prospective study confirmed strong associations between ... head and neck in both genders. , Cancers of ...
... of study to aid researchers in hunt for treatments ... public online database launched recently may help speed efforts ... bipolar disorder, a mood disorder commonly marked by alternating ... Disorder Phenome Database -- a joint project of the ...
... WESTCHESTER, Ill. For most children and teens, the beginning ... Not only will they be hitting the books again ... also participate in after-school activities. More research is emerging ... the number of children and teens who are considered obese ...
... study suggests that where the fat is stored is key ... a person is destined to develop diabetes, experiments in mice ... is stored. , Mice that overate and were very ... hormones let them store extra calories in fat tissue rather ...
Cached Medicine News:Health News:AASM encourages those student-athletes at risk for developing osa to visit a sleep clinic 2Health News:AASM encourages those student-athletes at risk for developing osa to visit a sleep clinic 3Health News:AASM encourages those student-athletes at risk for developing osa to visit a sleep clinic 4Health News:Obesity Doesn't Always Equal Diabetes 2Health News:Obesity Doesn't Always Equal Diabetes 3
(Date:10/22/2014)...  Cephasonics, a technology-innovation leader with a game-changing embedded-ultrasound ... Ultrasound Box™-1), the first product in a new family ... Cephasonics for purchase by companies to rebrand with their ... showcasing the cQUB-1 for the first time at CMEF ... Chongqing, China from October 23 to 26. ...
(Date:10/22/2014)... 22, 2014  Quest Diagnostics (NYSE: DGX ... today announced that its Board of Directors has elected ... effective December 1, 2014. Including Dr. Leiden, the Board ... Chairman, President and CEO of Vertex Pharmaceuticals.   Dr. ... commercial experience in the pharmaceutical and biotechnology industries as ...
(Date:10/22/2014)... 22, 2014 Antigen Discovery Inc. (ADi), a ... , announced the receipt of a National Institutes of ... from the National Institute of Dental and Craniofacial Research (NIDCR). ... a Pan-HIV Protein Microarray Chip, which will contain every ... and aid in the development of safe and effective ...
Breaking Medicine Technology:Cephasonics Launches the cQUB-1, First Product in New Family of cQUB White-Label Ultrasound Systems Targeted at Medical Applications 2Cephasonics Launches the cQUB-1, First Product in New Family of cQUB White-Label Ultrasound Systems Targeted at Medical Applications 3Quest Diagnostics Adds Jeffrey M. Leiden, M.D., Ph.D., to Board of Directors 2Quest Diagnostics Adds Jeffrey M. Leiden, M.D., Ph.D., to Board of Directors 3Biomarker Discovery Company, Antigen Discovery Inc., Awarded an NIH Phase I Small Business Innovation Research Grant to Develop a Pan-HIV Protein Microarray Chip 2
... 2011  Seventeen of the 19 medical-surgical suppliers and healthcare ... 25 for 2011 work with GHX to automate and ... them achieve high-quality patient care at optimal economic cost. ... and providers recognized by Gartner in the Top 25 ...
... 2011 ULURU Inc. (NYSE AMEX: ... of the previously announced European license for Altrazeal®, with a ... Zealand. Extending the European territory to include ... is a common registration process and the marketing strategy and ...
Cached Medicine Technology:GHX Salutes 17 Healthcare Organizations That Use Its Technology for Inclusion on a Leading Analyst Firm's 2011 Healthcare Supply Chain Top 25 List 2ULURU Inc. Extends the European Altrazeal® License to Include Australia and New Zealand 2ULURU Inc. Extends the European Altrazeal® License to Include Australia and New Zealand 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: