Navigation Links
Maintaining immune balance involves an unconventional mechanism of T cell regulation
Date:7/3/2013

New findings from St. Jude Children's Research Hospital reveal an unconventional control mechanism involved in the production of specialized T cells that play a critical role in maintaining immune system balance. The research appears in the current online edition of the scientific journal Nature.

The work focused on white blood cells known as regulatory T cells. These cells are crucial for a balanced immune response. Regulatory T cells suppress other immune system components in order to protect healthy tissue from misguided immune attacks or to prevent runaway inflammation.

St. Jude researchers showed that a molecular complex called mTORC1 uses an unconventional process to serve as a rheostat, controlling the supply and function of regulatory T cells. Loss of mTORC1 activity impairs the regulatory T cells that suppress the immune system's inflammatory response. The mTORC1 complex is part of the mTOR pathway, which was thought to inhibit rather than promote the number and function of regulatory T cells.

"These results challenge the prior view of the mTOR pathway as an inhibitor of these key immune cells and highlight the role of the mTORC1 complex in regulating the T cells that are vital for controlling inflammation," said Hongbo Chi, Ph.D., an associate member of the St. Jude Department of Immunology and the paper's corresponding author.

The findings also identified the mechanism mTORC1 uses in programming regulatory T cells to function as immune suppressors. Chi said the results should aid efforts to develop new drugs for use in organ transplantation or for treatment of autoimmune disorders.

For this study, researchers used specially bred mice to explore the mTOR pathway's role in the function of regulatory T cells. Investigators demonstrated mTORC1's importance by selectively deleting genes that carry instructions for making key elements of mTORC1 and a related complex. The deletion that targeted mTORC1 re
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Clemson researchers collect and reuse enzymes while maintaining bioactivity
2. Penn-Temple team discovers gatekeeper for maintaining health of cell energy source
3. Federal government renews contract for collecting and maintaining national stem cell transplantation database
4. Maintaining weight loss as important as losing it for older women
5. RI Hospital: Radiation can be reduced while maintaining high quality in CT colonography
6. AIG study shows hospital C-Suite and Risk Managers struggle with maintaining patient safety
7. Research Shows Non-Chain Restaurants Serve Excessive Calorie Meals, Making Appetite Suppressants Like Liproxenol Helpful With Maintaining Portion Control
8. Daimer Unveils Carpet Cleaner For Maintaining Health Clubs
9. Hearst Tower Window Washers Pulled To Safety After Scaffold Buckles; Construction Injury Lawyers Block O'Toole & Murphy, LLP Call For Maintaining Worker Safety Laws
10. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Offer Patients Fast Weight Loss With New hCG Diets, Easily Maintaining Weight In the Future With Healthy Eating
11. How does the immune system fight off threats to the brain? New research yields fresh insight
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... (PRWEB) July 14, 2014 ... Ultra performance liquid chromatography or UPLC is ... of liquid chromatography that involves the use ... conditions to separate chromatographic compounds. This highly ... faster detection and analysis of chromatography samples. ...
(Date:7/14/2014)... July 14, 2014 Skin ... its Grand Opening on Monday, July 14th, located ... The celebration will last all week through Saturday, ... patients. Everyone is welcomed to attend. The business ... provides physician-administered skincare, anti-aging, weight loss services, and ...
(Date:7/14/2014)... 2014 KeyPoint Credit Union is teaming ... 5K run and one-mile family fun walk. The run ... attractions, and finishes inside Levi’s® Stadium. , Over the ... for the Mission City Community Fund. All proceeds benefit ... , Seasoned athletes, part-time pavement-pounders and walkers are invited ...
(Date:7/14/2014)... July 14, 2014 T.E.N., an ... firm, announced today that nominations will be accepted ... Information Security Executive® (ISE®) North America Awards. ... the Year, which recognizes executives who have made ... management, data-asset protection, regulatory compliance, privacy and information ...
(Date:7/14/2014)... 14, 2014 Many people are unhappy ... plastic surgery to reduce a “double chin.” A ... the need to go under the knife. Jawflex is ... jaw muscles, therefore tightening the skin in that area ... Jawflex is used for facial exercise, double chin elimination ...
Breaking Medicine News(10 mins):Health News:Need for Faster Sample Analysis Drives Demand for UPLC, According to New Trend Report Published by Global Industry Analysts, Inc. 2Health News:The Cosmetic Medic Announces Grand Opening of New Skin M.D., a Physician-Administered Anti-aging, Skincare, and Weight Loss Practice 2Health News:The Cosmetic Medic Announces Grand Opening of New Skin M.D., a Physician-Administered Anti-aging, Skincare, and Weight Loss Practice 3Health News:T.E.N. Accepting Nominations for the 2014 Information Security Executive® North America Awards 2Health News:T.E.N. Accepting Nominations for the 2014 Information Security Executive® North America Awards 3Health News:Jawflex | Double Chin Exercise for Double Chin Reduction 2
... Medical Center have uncovered a protein in nerve cells that ... manufacture drugs that are capable of blocking chronic pain, by ... alleviating chronic pain have focused on the "second order" neurons ... brain. It's difficult to inhibit the activity of these neurons ...
... and Social Welfare’s Health Education Unit (HEU) in Swaziland ... than 40 communities in the country. // ... get the people thinking abut HIV AIDS through documentaries. ... Public Relations Officer Nana Mdluli said the campaign would ...
... the investigators at St. Jude Children's Research Hospital it was ... gland function during nursing can also initiate leukemias. // ... and fuses with another gene. The discovery of the normal ... the activity of its mutated form might be used in ...
... age 45 years or older who experience migraines with ... are at a higher risk for heart// attack, ischemic ... compared to women who do not report a migraine ... form of migraine, was not associated with increased risk ...
... at Buffalo researchers are conducting one of the ... ,The project is expected to provide ... quality is critical, such as in health-care facilities ... guest rooms in the Buffalo Niagara Marriott in ...
... China on Saturday reported a new outbreak of bird flu ... Xinjiang.// ,The national avian influenza laboratory tested samples ... stemming from an outbreak that began on July 14 near ... ,A total of 3,045 chickens died in the outbreak, and ...
Cached Medicine News:Health News:It may be possible to switch off acute pain 2Health News:Gene Responsible For Mammary Gland Function, When Mutated Results in Leukemias 2Health News:Gene Responsible For Mammary Gland Function, When Mutated Results in Leukemias 3Health News:Migraines with Aura Associated with Increased Risk for Cardiovascular Disease 2Health News:Scientists Put "Allergy-Friendly" Hotel Rooms to the Test 2Health News:Scientists Put "Allergy-Friendly" Hotel Rooms to the Test 3
(Date:7/14/2014)... 14, 2014  Invivotek L.L.C., a member of ... announce that its animal research facility was awarded ... and Accreditation of Laboratory Animal Care International (AAALAC). ... science worldwide through voluntary accreditation and assessment programs. ... and use in 38 countries. Invivotek ...
(Date:7/14/2014)... , July 14, 2014  Remedy Informatics, the ... healthcare delivery and life sciences research, announced that ... Foundation (NPF) to build the first-ever national patient ... cancer and pancreatitis. "The National Pancreas ... change that thoughtful and committed organizations can effect ...
(Date:7/14/2014)... SAN DIEGO , July 14, 2014  More than ... love their smartphones and tablet computers -- but their eyes ... humans have never needed before, and the eye has not ... lives and what our eyes can do comfortably often results ... symptoms collectively known as Digital Eye Strain. Now ZEISS has ...
Breaking Medicine Technology:Invivotek Awarded Full AAALAC Accreditation for Excellence in Laboratory Animal Care and Use 2Remedy Informatics Partners with National Pancreas Foundation to Build a National Patient Registry 2Remedy Informatics Partners with National Pancreas Foundation to Build a National Patient Registry 3New Eyeglass Lens Helps Our Eyes Keep Up with our Digital Lives 2New Eyeglass Lens Helps Our Eyes Keep Up with our Digital Lives 3
... VOLC ), a leading developer and manufacturer of ... and treatment of coronary and peripheral vascular disease, today announced ... quarter of fiscal 2011 on Wednesday, May 4. ... financial results and operating activities open to all interested parties ...
... 25, 2011 STAAR Surgical Company (NASDAQ: ... minimally invasive ophthalmic lenses for refractive surgery, today announced ... (ICL™) V4c design.  The V4c design incorporates a proprietary ... a size determined to optimize the flow of fluid ...
Cached Medicine Technology:Volcano Corporation Schedules First Quarter Conference Call, Webcast 2Visian® ICL and Toric ICL V4c Receive CE Mark Approval 2Visian® ICL and Toric ICL V4c Receive CE Mark Approval 3Visian® ICL and Toric ICL V4c Receive CE Mark Approval 4
Stryker's 40-liter insufflator provides superior performance with unprecedented safety and reliability....
Bipolar forceps...
... visualize the presence of Human Papilloma Virus (HPV)., ... sample types: tissue, monolayer-based preparations, and conventional Pap. ... The Family 16 probe cocktail has an affinity ... 39, 51, 52, 56, 58, and 66. The ...
... Common primary human fungal pathogens ... spp., opportunistic fungal pathogens, including ... cerevisiae, Acremonium, Coccidioides immitis, Histoplasma ... and Pneumocystis carinii. The (1-3)--D-glucan ...
Medicine Products: