Navigation Links
Maintaining immune balance involves an unconventional mechanism of T cell regulation
Date:7/3/2013

New findings from St. Jude Children's Research Hospital reveal an unconventional control mechanism involved in the production of specialized T cells that play a critical role in maintaining immune system balance. The research appears in the current online edition of the scientific journal Nature.

The work focused on white blood cells known as regulatory T cells. These cells are crucial for a balanced immune response. Regulatory T cells suppress other immune system components in order to protect healthy tissue from misguided immune attacks or to prevent runaway inflammation.

St. Jude researchers showed that a molecular complex called mTORC1 uses an unconventional process to serve as a rheostat, controlling the supply and function of regulatory T cells. Loss of mTORC1 activity impairs the regulatory T cells that suppress the immune system's inflammatory response. The mTORC1 complex is part of the mTOR pathway, which was thought to inhibit rather than promote the number and function of regulatory T cells.

"These results challenge the prior view of the mTOR pathway as an inhibitor of these key immune cells and highlight the role of the mTORC1 complex in regulating the T cells that are vital for controlling inflammation," said Hongbo Chi, Ph.D., an associate member of the St. Jude Department of Immunology and the paper's corresponding author.

The findings also identified the mechanism mTORC1 uses in programming regulatory T cells to function as immune suppressors. Chi said the results should aid efforts to develop new drugs for use in organ transplantation or for treatment of autoimmune disorders.

For this study, researchers used specially bred mice to explore the mTOR pathway's role in the function of regulatory T cells. Investigators demonstrated mTORC1's importance by selectively deleting genes that carry instructions for making key elements of mTORC1 and a related complex. The deletion that targeted mTORC1 resulted in dramatically reduced immune suppression by regulatory T cells and the mice rapidly developed a fatal inflammatory disorder.

Researchers also showed that mTORC1 works by integrating signals from two immune receptors on the cell surface with cholesterol metabolism. With the right input, mTORC1 promoted production of regulatory T cells and cemented their role as suppressors of immune activity.

In another twist, investigators linked that suppressive function to cholesterol and lipid metabolism. Rather than relying on more conventional strategies of immune regulation, researchers showed how regulatory T cells depend on the metabolic pathway to control production of molecules CTLA4 and ICOS, which are responsible for immune suppression. Production of CTLA4 and ICOS by regulatory T cells decreased as lipid metabolism dropped. "We are just starting to appreciate the importance of lipids in the immune system, particularly in the function of regulatory T cells," Chi said.


'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Related medicine news :

1. Clemson researchers collect and reuse enzymes while maintaining bioactivity
2. Penn-Temple team discovers gatekeeper for maintaining health of cell energy source
3. Federal government renews contract for collecting and maintaining national stem cell transplantation database
4. Maintaining weight loss as important as losing it for older women
5. RI Hospital: Radiation can be reduced while maintaining high quality in CT colonography
6. AIG study shows hospital C-Suite and Risk Managers struggle with maintaining patient safety
7. Research Shows Non-Chain Restaurants Serve Excessive Calorie Meals, Making Appetite Suppressants Like Liproxenol Helpful With Maintaining Portion Control
8. Daimer Unveils Carpet Cleaner For Maintaining Health Clubs
9. Hearst Tower Window Washers Pulled To Safety After Scaffold Buckles; Construction Injury Lawyers Block O'Toole & Murphy, LLP Call For Maintaining Worker Safety Laws
10. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Offer Patients Fast Weight Loss With New hCG Diets, Easily Maintaining Weight In the Future With Healthy Eating
11. How does the immune system fight off threats to the brain? New research yields fresh insight
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... MI (PRWEB) , ... December 07, 2016 , ... ... and financial consultation services from offices located in South Lyon, Dewitt, Williamston, East ... benefit a basketball coach who needs treatment for a brain tumor. , Jason ...
(Date:12/7/2016)... ... December 07, 2016 , ... A. Kevin Spann Insurance, a New York-based ... Five Boroughs, is launching a charity drive to raise funds that will benefit the ... spirit of marines and Navy FMF Corpsmen. Working closely with the MCL, the A. ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... Delete® - ... in Time For The Holiday Party Season. Save Up To 33% Off Botox® and ... Salon is providing the Phoenix Valley with Delightful Deals on Botox® and ...
(Date:12/7/2016)... ... December 07, 2016 , ... Gensuite is ... Awards under the Best New Product Launch category. Gensuite’s entry on their EZ ... , BOC Global Events & Training Group is a professional event and training ...
(Date:12/7/2016)... ... 07, 2016 , ... “Walking With God: Inspirational Lessons from My Life's Journey”: ... to be aware of God's direction in their lives. “Walking With God: Inspirational Lessons ... and active church leader. , Sanford says, “I enjoy sharing the true ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)... 6, 2016 Radioisotopes are radioactive isotopes having ... either by using nuclear research reactor or by using ... alpha, beta or gamma when changed to a stable ... Nuclear medicine, specifically in medical diagnostics. In this field, ... a human body,s functioning. Radiotherapy is also used to ...
(Date:12/6/2016)... Anaplastic Oligoastrocytoma - Pipeline Review, H2 ... Pharmaceutical and Healthcare disease pipeline guide Anaplastic Oligoastrocytoma ... of the Anaplastic Oligoastrocytoma (Oncology) pipeline landscape. ... when two types of cells in the brain, ... to form a mass. These brain cells are ...
(Date:12/6/2016)... Dec. 6, 2016   AlloSource , one ... bone, skin and soft-tissue allografts for use in ... Process Manager, for being named to the Board ... Quality Award by the Commerce Department,s National Institute ... commitment to process excellence. The Baldrige Award is ...
Breaking Medicine Technology: