Navigation Links
Maintaining immune balance involves an unconventional mechanism of T cell regulation
Date:7/3/2013

New findings from St. Jude Children's Research Hospital reveal an unconventional control mechanism involved in the production of specialized T cells that play a critical role in maintaining immune system balance. The research appears in the current online edition of the scientific journal Nature.

The work focused on white blood cells known as regulatory T cells. These cells are crucial for a balanced immune response. Regulatory T cells suppress other immune system components in order to protect healthy tissue from misguided immune attacks or to prevent runaway inflammation.

St. Jude researchers showed that a molecular complex called mTORC1 uses an unconventional process to serve as a rheostat, controlling the supply and function of regulatory T cells. Loss of mTORC1 activity impairs the regulatory T cells that suppress the immune system's inflammatory response. The mTORC1 complex is part of the mTOR pathway, which was thought to inhibit rather than promote the number and function of regulatory T cells.

"These results challenge the prior view of the mTOR pathway as an inhibitor of these key immune cells and highlight the role of the mTORC1 complex in regulating the T cells that are vital for controlling inflammation," said Hongbo Chi, Ph.D., an associate member of the St. Jude Department of Immunology and the paper's corresponding author.

The findings also identified the mechanism mTORC1 uses in programming regulatory T cells to function as immune suppressors. Chi said the results should aid efforts to develop new drugs for use in organ transplantation or for treatment of autoimmune disorders.

For this study, researchers used specially bred mice to explore the mTOR pathway's role in the function of regulatory T cells. Investigators demonstrated mTORC1's importance by selectively deleting genes that carry instructions for making key elements of mTORC1 and a related complex. The deletion that targeted mTORC1 resulted in dramatically reduced immune suppression by regulatory T cells and the mice rapidly developed a fatal inflammatory disorder.

Researchers also showed that mTORC1 works by integrating signals from two immune receptors on the cell surface with cholesterol metabolism. With the right input, mTORC1 promoted production of regulatory T cells and cemented their role as suppressors of immune activity.

In another twist, investigators linked that suppressive function to cholesterol and lipid metabolism. Rather than relying on more conventional strategies of immune regulation, researchers showed how regulatory T cells depend on the metabolic pathway to control production of molecules CTLA4 and ICOS, which are responsible for immune suppression. Production of CTLA4 and ICOS by regulatory T cells decreased as lipid metabolism dropped. "We are just starting to appreciate the importance of lipids in the immune system, particularly in the function of regulatory T cells," Chi said.


'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Related medicine news :

1. Clemson researchers collect and reuse enzymes while maintaining bioactivity
2. Penn-Temple team discovers gatekeeper for maintaining health of cell energy source
3. Federal government renews contract for collecting and maintaining national stem cell transplantation database
4. Maintaining weight loss as important as losing it for older women
5. RI Hospital: Radiation can be reduced while maintaining high quality in CT colonography
6. AIG study shows hospital C-Suite and Risk Managers struggle with maintaining patient safety
7. Research Shows Non-Chain Restaurants Serve Excessive Calorie Meals, Making Appetite Suppressants Like Liproxenol Helpful With Maintaining Portion Control
8. Daimer Unveils Carpet Cleaner For Maintaining Health Clubs
9. Hearst Tower Window Washers Pulled To Safety After Scaffold Buckles; Construction Injury Lawyers Block O'Toole & Murphy, LLP Call For Maintaining Worker Safety Laws
10. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Offer Patients Fast Weight Loss With New hCG Diets, Easily Maintaining Weight In the Future With Healthy Eating
11. How does the immune system fight off threats to the brain? New research yields fresh insight
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2017)... ... 2017 , ... “Congratulations! It's A Boy! God’s Gift: A Story of Love”: ... God. “Congratulations! It's A Boy! God’s Gift: A Story of Love” is the creation ... York. , Published by Christian Faith Publishing, Dale Anthony and Rachael Anthony’s new book ...
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... ... “Vision & Hearing” campaign, advocating for active, healthy lifestyles and highlighting the importance ... for individuals with hearing impairments and shares the latest innovations in hearing aid ...
(Date:8/18/2017)... ... 2017 , ... Hernandez Insurance Agencies, a northern Virginia firm ... DC region, is inaugurating a “New Leash On Life” charity initiative in conjunction ... to be companions for veterans in need. , The Semper K9 organization works ...
(Date:8/18/2017)... ... 18, 2017 , ... Goss & Associates Insurance Agency, a ... clients in the greater Houston region, is helping locally recognized nonprofit Addi’s Faith ... cancer. , Founded by Tony and Amber Bender after losing their young daughter ...
(Date:8/18/2017)... Boca Raton (PRWEB) , ... August 18, 2017 , ... ... is continuing to ramp up its marketing efforts with its product now available through ... hangover remedy to the public. The effervescent powdered drink is designed to quickly detox ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... , Aug. 15, 2017  AOTI Inc. announced today that ... Therapy Inc., has recently opened a New York City Office in ... usage of its unique Topical Wound Oxygen (TWO 2 ) homecare ... the Accreditation Commission for Health Care (ACHC) under the company,s DMEPOS ... ...
(Date:8/8/2017)...   Second-quarter 2017 revenues of ... share from continuing operations ... to $110 million Second-quarter ... million Second-quarter 2017 adjusted ... 8 percent to $0.93 ...
(Date:8/7/2017)... , Aug. 7, 2017  Endo International plc (NASDAQ: ... agreements to resolve virtually all known U.S. mesh product ... to resolve the known remaining U.S. claims at reasonable ... beginning in the fourth quarter of 2017 and continuing ... its second quarter 2017 results, the Company intends to ...
Breaking Medicine Technology: