Navigation Links
Mailman School PH study finds increase in thyroid diseases risk from exposure at Chernobyl
Date:2/19/2008

February 19, 2008 -- Persons exposed to radioactive fallout from the Chernobyl accident as children and adolescents have an increased risk of follicular adenoma or benign tumor of the thyroid gland, according to researchers at Columbia University Mailman School of Public Health. Results of the study further suggest that age at exposure, history of thyroid diseases, and location of residence do not modify its risk. This is the first epidemiologic study of the association between radiation exposure from radioactive iodine fallout from the Chernobyl accident and subsequent risk of follicular adenoma in those exposed at 18 years old or younger. The paper is published in the February 2008 issue of the American Journal of Epidemiology.

The Chernobyl accident in 1986 was the largest nuclear accident ever and exposed many individuals to radioactive iodines. Thyroid cancer is one of the most radiosensitive tumors when exposure occurs at young ages. Previous studies showed that the risk of thyroid cancer increased with radiation dose from radioactive iodines, but the effects of radiation on benign thyroid diseases has been largely unknown.

Researchers selected a random sample of 32,385 persons from a database of more than 75,000 records of thyroid radioactivity measurements taken within two months after the incident in those under the age of 18 who resided in three heavily contaminated areas in Ukraine. Various methods were used to trace these subjects and invite them for screening which consisted of an examination of the thyroid gland and sonogram, blood and urine tests, a detailed questionnaire, and an independent clinical examination by an endocrinologist. Those with suspicious findings were further referred for fine-needle biopsy and surgery as needed. The scientists reported a significant three-fold increase in risk for those exposed to the standard measure of 1 gray of radiation compared to those with zero dose. The study further indicates that women had a notably higher risk of follicular adenoma compared with men.

The Chernobyl accident presented an unparalleled opportunity to study the association between radioactive iodines and a spectrum of thyroid diseases, said Lydia B. Zablotska, MD, PhD, principal investigator of the project and assistant professor of Epidemiology at the Mailman School of Public Health. While there have been several analytical epidemiologic studies of thyroid cancer following the Chernobyl accident, none had evaluated follicular adenoma in particular. This paper presents risk estimates of follicular adenoma in relation to individual thyroid doses as well as the effects of gender, age at exposure, iodine deficiency, and other possible effect-modifying factors.

The researchers note that the radioactive iodines accumulated in the human thyroid gland via the consumption of contaminated milk and other food items. Various earlier studies have shown that the populations of Ukraine, Belarus, and the Russian Federation experienced large increases of thyroid cancer in those exposed to the fallout before the age of 18 years. This increase became apparent 45 years after the accident and confirmed previous suggestions.

Also among the major strengths of the Mailman School study are the availability of individual thyroid doses based on thyroid radioactivity measurements made within two months after the accident and the data collected during screening. While the researchers caution that these results are based on a small number of cases, our findings are further strengthened by the high fine-needle biopsy compliance rate of 93 percent. Because all those referred for surgery following fine-needle aspiration biopsy have been operated upon, it is unlikely that follicular adenoma was underdiagnosed, Dr. Zablotska said.

Ukraine is known to have a mild to moderate iodine deficiency previously shown to affect radiation-related risks of thyroid cancer. In this study several indicators of iodine deficiency such as place of residence, history of thyroid diseases, and current urinary iodine excretion did not modify the risk of follicular adenoma.

Our findings confirm that follicular adenoma is strongly related to exposure from radioactive iodines, and while we found that the risk is modified by gender, age at exposure, place of residence, and personal history of thyroid diseases do not affect its subsequent development, said Dr. Zablotska.


'/>"/>

Contact: Stephanie Berger
sb2247@columbia.edu
212-305-4372
Columbia University's Mailman School of Public Health
Source:Eurekalert

Related medicine news :

1. Body image is stronger predictor of health than obesity, says Mailman School of PH study
2. Black gay men, lesbians, have fewer mental disorders than whites, says Mailman School of PH study
3. Climate may increase heat-related deaths by 2050s, says Mailman School of PH study
4. Mailman School of Public Health study examines link between racial discrimination and substance use
5. Fixing Poor Vision Boosts Preschoolers Test Scores
6. Hondros College Expands School of Nursing to Columbus and Dayton; Students Can Begin LPN Education Almost Immediately
7. FSDDS Creates New Sun Defense Essay Contest Throughout Florida Elementary Schools
8. Congresswoman Sutton Leads National Effort to Place Life-Saving AEDs in Americas Schools
9. IAS Teams Up with RiskWatch to Offer New Hospital Security and School Security Risk Assessments
10. A dangerous transition: High school to the first year of college
11. Friends school achievement influences high school girls interest in math
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills is proud ... and unique items from across the nation, this holiday-themed event will raise funds and ... the VNA. The boutique will be open Saturday, November 4 (10:00 a.m. – ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Software Development, has been awarded a contract by the Center for Medicare and ... aims to accelerate the enterprise use of Agile methodologies in a consistent and ...
(Date:10/12/2017)... ... ... Planet Fitness, one of the largest and fastest growing franchisors and operators ... location in Covington, LA at 401 N. U.S. Highway 190, in January of 2018. ... in the Holiday Square shopping center. Its location allows it to serve both Covington ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... delivery system that we intend to develop to enable prevention of a major ... to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss is ...
(Date:10/12/2017)... GRAND RAPIDS, Mich. (PRWEB) , ... October 12, ... ... OnSite Wellness, has been named one of Michigan’s 2017 Best and Brightest in ... Best and Brightest in Wellness® awards program on Friday, Oct. 20 from 7:30 ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... announces the European launch of their new low volume, high throughput ... Cambridge, U.K on October 4th. The new ... unprecedented speed and sensitivity while using far less sample volume through ... ... ...
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation ... and home sensors for real-time monitoring of patients with ... nonprofit organization focused on disruptive health solutions for rare ... system to record and integrate behavioral, cognitive, physiological and ... ...
(Date:9/25/2017)... , Sept. 25, 2017   Montrium ... Master File solutions, today—from the IQPC Trial Master ... , NL)—announced that EastHORN Clinical Services has ... clinical programs and TMF management. EastHORN, a leading ... eTMF platform to increase transparency to enable greater ...
Breaking Medicine Technology: