Navigation Links
Magnetic nanoparticles: Suitable for cancer therapy?
Date:5/28/2008

This release is available in German.

A measuring procedure developed in the Physikalisch-Technische Bundesanstalt (PTB) can help to investigate in some detail the behaviour of magnetic nanoparticles which are used for cancer therapy.

Magnetic nanoparticles (with a size of some few to several hundred nanometres) are a new, promising means of fighting cancer. The particles serve as a carrier for drugs: "loaded" with the drugs, the nanoparticles are released into the blood stream, where they move until they come under the influence of a targeting magnetic field which holds them on to the tumour until the drug has released its active agent. Besides this pharmaceutical effect, also a physical action can be applied: an electromagnetic a.c. field heats up the accumulated particles so much that they destroy the tumour. Both therapeutic concepts have the advantage of largely avoiding undesired side effects on the healthy tissue.

These procedures have already been successfully been applied in the animal model and have, in part, already been tested on patients. Here it is important to know before application whether the particles tend to aggregate and thus might occlude blood vessels.

Information about this can be gained by magnetorelaxometry developed at the PTB. In this procedure, the particles are shortly magnetised by a strong magnetic field in order to measure their relaxation after the switch-off of the field by means of superconducting quantum interferometers, so-called "SQUIDs". Conclusions on their aggregation behaviour in these media can be drawn from measurements of suspensions of nanoparticles in the serum or in whole blood. As an example, it could be shown in this way that certain nanoparticles in the blood serum form clusters with a diameter of up to 200 nm a clear indication of aggregation, so that these nanoparticles do not appear to be suitable for therapy.

At present, the high technical effort connected with the use of helium-cooled magnetic field sensors is still standing in the way of using this method routinely in practice. In a joint project with Braunschweig Technical University supported by the Ministry of Education and Research (BMBF), the procedure is currently being transferred to a simpler technology based on fluxgate magnetometers.


'/>"/>

Contact: Dr. Lutz Trahms
lutz.trahms@ptb.de
49-303-481-7213
Physikalisch-Technische Bundesanstalt (PTB)
Source:Eurekalert

Related medicine news :

1. Stereotaxis Niobe Magnetic Navigation Systems Perform Approximately 15,000 Cases
2. Increased level of magnetic iron oxides found in Alzheimers disease
3. NMR on a chip features NIST magnetic mini-sensor
4. Electromagnetics in Everyday Life
5. Society of Cardiovascular Magnetic Resonance chooses open access
6. Transcranial magnetic stimulation: An effective treatment for depression
7. Penn research shows transcranial magnetic stimulation effective in treating major depression
8. Bayer HealthCare Pharmaceuticals and MedAssets Supply Chain Systems Sign a Three-Year Agreement for Magnevist(R) Magnetic Resonance Contrast Media
9. A Magnetic Presence: Siemens New MRI Systems Pulling More Patients Toward the Benefits of MR Imaging
10. Stereotaxis Highlights Live Coronary and Peripheral Vascular Cases Performed at TCT With Stereotaxis Magnetic Navigation System
11. Stereotaxis Showcases Interventional Cardiology Capabilities of Niobe Magnetic Navigation System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... , ... January 23, 2017 , ... ... production applications. However, choosing the right method is paramount to success. Selecting an ... often in situations where multiple persons use the same equipment. Rare or expensive ...
(Date:1/23/2017)... ... January 23, 2017 , ... Gynecology Associates of Gwinnett ... gynecological services for women of all ages. The staff of Gynecology Associates ... reproductive services from routine health screenings to diagnosing and treating female concerns including ...
(Date:1/23/2017)... ... January 23, 2017 , ... “Some Infallible Characteristics of Christ”: a ... Characteristics of Christ” is the creation of published author, Rev. Dr. Robert W. Thomas, ... thirteen years, a preacher for over nineteen, a pastor for over fifteen years. He ...
(Date:1/22/2017)... ... January 22, 2017 , ... Medical lab testing ... the results of a simple test will take days to arrive to the end ... offers customers direct access to their lab tests, bypassing the cost and delay of ...
(Date:1/21/2017)... ... January 21, 2017 , ... Phytocéane invites you ... from the rest of the world with ZANZIBAR SHOWER GEL. Inspired by the beauty ... ingredients, Virgin Coconut Oil and moisturizing vegetal coral to create this gentle, crystal-clear shower ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... The global  anxiety disorders and depression treatment market  is expected to reach ... worldwide is anticipated to drive the market growth in the coming years. Increasing ... in the recent years. Continue Reading ... ... ...
(Date:1/23/2017)... , Jan 23, 2017 NeuroVive Pharmaceutical ... has signed a preclinical collaboration agreement with the Children,s Hospital ... J. Falk , M.D., a US key opinion leader in ... ... will evaluate compounds from NeuroVive,s research program, NVP015, in certain ...
(Date:1/21/2017)... , Jan 20, 2017 Research ... Clinical Laboratory Testing Market By Type of Test (Tumor, Clinical ... & By Type of Diseases (Tuberculosis, Influenza, Cancer, HIV/AIDS etc.), ... ... attractive destination for healthcare services, market segments, especially clinical lab ...
Breaking Medicine Technology: