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Magnetic-anchor-guided endoscopic submucosal dissection shows promise for gastric cancer
Date:1/27/2009

ope and a liquid solution is injected under the area of interest, in effect "lifting" the abnormal tissue and separating it from the deeper intestinal layers. The abnormal lesion is then removed ("resected") with a snare; the tissue is subsequently retrieved through the endoscope and examined under a microscope.

ESD is a specific EMR technique where a lesion, generally larger than what can be removed by standard EMR, is separated from the deeper layers of the intestinal wall under direct vision of the endoscopist. The endoscopist utilizes an electrocautery device to dissect the lesion (overlying the device) from the deeper intestinal layers (below the device). Unlike conventional surgery, where structures in the abdomen are readily able to be shifted (retracted) allowing better visualization, there is no good method to provide retraction when using the endoscope in ESD. MAG-ESD, controlled by an extracorporeal electromagnet, facilitates the standard ESD procedure by providing this retraction capability using magnets.

According to the researchers, the MAG-ESD technique allowed for excellent visualization of the submucosal layer because it made suitable tissue tension possible. This simplifies a gastric ESD, even for large lesions in the gastric body. The study showed that the long-term exposure to the magnetic field did not cause any unwanted physiological or mental effects. Furthermore, no delayed complications or allergies related to the stainless steel magnetic anchor were observed. All the tumors were resected en bloc, without any perforation or severe uncontrollable bleeding.

Patients and Methods

The purpose of this prospective single center clinical trial was to evaluate the feasibility of MAG-ESD for large early gastric cancer in humans. The technique had previously been reported as successful in a porcine model. Twenty-five patients, median age 70 years, with early gastric cancer measuring > 20 mm located in the gast
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Contact: Anne Brownsey
abrownsey@asge.org
630-570-5635
American Society for Gastrointestinal Endoscopy
Source:Eurekalert

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