OAK BROOK, Ill. January 27, 2009 A prospective clinical trial from researchers in Japan shows magnetic-anchor-guided endoscopic submucosal dissection for large early gastric cancer to be a feasible and safe method in humans. Endoscopic submucosal dissection (ESD) is useful in the en bloc removal (in a single large piece) of large gastric lesions because it reduces the risk of a local recurrence caused by removing the lesions piecemeal (in multiple small pieces). ESD is a complicated procedure that requires a high level of skill by the endoscopist. The magnetic-anchor-guided endoscopic submucosal dissection (MAG-ESD) technique was developed to facilitate the standard ESD procedure. The researchers note that to their knowledge, this is the first clinical trial to use MAG-ESD for early gastric cancer in humans. The study appears in the January issue of GIE: Gastrointestinal Endoscopy, the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy (ASGE).
Endoscopy is a procedure that uses an endoscope -- a thin, flexible tube with a light and a lens on the end to look into the esophagus, stomach, duodenum, small intestine, colon, or rectum, in order to diagnose or treat a condition. There are many types of endoscopy, including colonoscopy, sigmoidoscopy, gastroscopy, enteroscopy, and esophogogastroduodenoscopy (EGD). Endoscopy allows direct visualization of the inner most lining of the gastrointestinal tract. This inner lining is called the mucosa. Many cancers originate from the mucosa of the gastrointestinal tract. Some examples include colon, esophageal and gastric (stomach) cancer.
Precancerous changes and early stage cancers can be removed through an endoscope provided the cancer has not spread beyond the surface layers of the gastrointestinal lining. An important technique in removing these lesions is endoscopic mucosal resection (EMR). In this technique, a needle is passed through the endosc
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American Society for Gastrointestinal Endoscopy