Navigation Links
Magnetic Fields Concentrate Drug Delivery
Date:4/24/2010

Medicine-loaded particles delivered directly to stents, researchers say

FRIDAY, April 23 (HealthDay News) -- Magnetic fields can be used to direct drug-loaded nanoparticles to metal stents in injured blood vessels, where they then release drugs that help prevent blood vessel blockages, U.S. researchers report.

In humans, stents -- small metal mesh tubes -- are often used to treat cardiovascular disease by acting as a scaffold to keep a partially clogged blood vessel open, and many are coated with medicine to further prevent the blood vessel from getting blocked.

In tests on lab rats, the new magnetic technique achieved better results at a lower dose than conventional non-magnetic therapy, according to study leader Dr. Robert J. Levy, chair of pediatric cardiology at the Children's Hospital of Philadelphia and colleagues.

Nanoparticles -- microscopic particles so tiny that a nanometer is one-millionth of a millimeter -- have recently attracted intense scientific interest. The results of this study may lead to the introduction of a new medical tool called vascular magnetic intervention.

"This can become a major platform technology for delivering drugs and other agents to specific sites where they can produce benefits in diseased or injured blood vessels," Levy said in a news release.

In this study, the researchers implanted stainless steel stents into lab rats carotid arteries -- the main arteries in the neck that supply blood to the brain. They then injected the rodents with nanoparticles impregnated with an iron oxide that responds strongly to a magnetic field. The researchers produced a uniform magnetic field around the rats for five minutes, which magnetized the stents and the nanoparticles. As a result, large numbers of the nanoparticles traveled to the stents and released a drug that helps keep arteries clear of blockages.

This use of magnetic fields to concentrate drug delivery produced better results than conventional therapy, researchers said.

The study appears in this week's online issue of the Proceedings of the National Academy of Sciences.

More information

The Society for Vascular Surgery has more about stenting.



-- Robert Preidt



SOURCE: Children's Hospital of Philadelphia, news release, April 19, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Texas Childrens Cancer Center first in Texas to magnetically lengthen 9-year-olds leg as she grows
2. Spinfinity™ Magnetic Stirring Bars From Bel-Art Products Deliver Up to Three Times Wear Resistance
3. Electromagnetic Pulses May Stem Arthritic Knee Pain
4. Electromagnetic pulses provide pain relief for osteoarthritis
5. Magnetic field measurements of the human heart at room temperature
6. VitaminSpice Elects Bill Fields to the Board of Directors
7. Tahitian Noni Pure is The Most Concentrated Bioactive Beverage Available
8. Panel questions VBAC bans, advocates expanded delivery options for women
9. Electronic Health Information Leader Says Physician Practice Redesign is Vital Next Step Towards Safer, More Effective Care Delivery
10. Targeted delivery of losartan reduces liver inflammation and scarring
11. Gourmet Diet Delivery Unites with First Lady's Battle Against Obesity The Fresh Diet Begins Delivering Meals to DC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2016)... , ... April 30, 2016 , ... “Aging well is a challenge for all of us, but there are things ... Parul T. Kohli . “Research is showing more and more that there are simple, yet ... and disability as we age.” Top priorities Dr. Kohli’s recommends for her patients include;, ...
(Date:4/29/2016)... (PRWEB) , ... April 30, 2016 , ... ... engineer of patented products, announces the Pick Up Springboard, an automotive invention that ... Light Truck Manufacturing industry is worth $162 billion," says Scott Cooper, CEO and ...
(Date:4/29/2016)... Los Angeles, CA (PRWEB) , ... April 29, 2016 , ... ... Sarah Mirmelli, a mother and divorcee, shares her enthusiasm for Botox and lip injections, ... of the world famous youth oriented Coachella Valley Music and Arts Festival. The article ...
(Date:4/29/2016)... ... April 29, 2016 , ... Memorial Healthcare System Graduate ... Education (ACGME) that it has received accreditation for its residency program on Physical ... programs that Memorial is currently pursuing, including Pediatrics and Internal Medicine. This accreditation ...
(Date:4/29/2016)... ... April 29, 2016 , ... Our bodies are bombarded daily by environmental and ... with these stressors is to adopt a more healthful diet, but too many people ... a certified Holistic Nutritionist and the creator of the Newport Beach Cleanse and 14-Day ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... New York , April 27, 2016 ... market report titled, "Skincare Devices Market - Global Industry ... 2023." According to the report, the global skincare devices ... and is anticipated to expand at a CAGR of ... Mn in 2023. Browse the full Skincare Devices ...
(Date:4/27/2016)...  Bayer Animal Health today announced that ... of Florida College of Veterinary Medicine, is the ... Award (BECA). Brittany was selected from entries representing ... of $70,000 in scholarship funds through the 2016 ... provided a total of $232,500 in scholarship awards ...
(Date:4/27/2016)... YORK , April 27, 2016 ... OASM ), a developer of a new generation ... announced positive overall survival results for Paclical/Apealea in ... of 789 patients with epithelial ovarian cancer. These ... groups: Paclical/Apealea in combination with carboplatin versus Taxol ...
Breaking Medicine Technology: