Navigation Links
'Magic number' 695 opens up new areas for Alzheimer's research
Date:11/15/2010

Alzheimer's disease is widely believed to be caused by the gradual accumulation in the brain of amyloid-beta peptide which is toxic to nerve cells. Amyloid beta peptide is formed from a protein known as APP, which is found in three forms. Most research into APP a key area of study for the disease does not distinguish between the different forms of the protein.

The findings, published in the Journal of Biological Chemistry, show that amyloid beta peptide is actually created mainly by just one form of APP known as APP695 for the number of its amino acids. APP695 is found at greater concentration in brain and nerve cells, but this study funded by the Medical Research Council and the Alzheimer's Research Trust is the first time the significance of that has been shown. This discovery will now enable research to focus more clearly on the exact mechanism by which amyloid beta peptide accumulates in the brain.

"Research into amyloid beta peptide has been going on for more than 20 years and while treatments have made it to clinical trials, nothing has proved truly effective against this disease," says Professor Tony Turner, from Leeds' Faculty of Biological Sciences, who co-led the research. "This could be because research to date has been a bit of a blunt instrument: scientists have essentially been working on too broad a field. Our findings will allow researchers to target their work much more precisely."

The study of APP695 also led the scientists to identify a potential new factor in the development of Alzheimer's. When APP is broken down, it forms another protein called AICD. The researchers discovered that AICD formed from APP695 switches on certain genes within nerve cells that may then damage the cell. The process is unique to nerve cells and AICD formed from the other forms of APP does not have this effect.

"AICD has been detected before, but because studies haven't differentiated between the different forms of APP, there was no consensus on its role," explains co-researcher Professor Nigel Hooper. "It seems likely that AICD formed from APP695 is a contributing factor in the deterioration in nerve and brain cells which leads to Alzheimer's. This provides another avenue for research into a potential cure for the disease."

Professor Chris Kennard, chair of the MRC Neurosciences and Mental Health Board, said: "This is the latest study from a long-term research collaboration to significantly further our understanding of neurodegenerative diseases, such as Alzheimer's Disease. It forms part of a 4.1m investment by the MRC and is a shining example of where fundamental research, which unravels the complex biology of disease, can provide the building blocks for potential treatments in future."

Dr Simon Ridley, Head of Research at the Alzheimer's Research Trust, said: "This study gives us important new insight into the role of APP in Alzheimer's disease, and could have significant implications for future research in this area. We must now build on these findings with more research, as this is the only way we will be able to find an effective treatment for dementia."

Over 820,000 people in the UK live with dementia and one in three over 65s will die with some form of the disease. The Alzheimer's Research Trust estimates that the annual cost to the UK economy is 23 billion.


'/>"/>

Contact: Prof Nigel Hooper
n.m.hooper@leeds.ac.uk
44-113-343-3163
University of Leeds
Source:Eurekalert

Related medicine news :

1. Vitamin D No Magic Bullet for Osteoarthritis
2. Magic Mushroom Hallucinogen Might Help Cancer Patients
3. Nautilus IDScan.net Presents New Drivers' License Parsing Component, a Magic Tool for Software Developers
4. Guardian Preservation Services Responds to Receiving the "National Home Pro of the Year Award" by ServiceMagic
5. Arsa Offers High Quality Supplements, Cosmetics and Magic Scents from Mexico for Less Than $10
6. A magical way to move kids
7. Aerohive Positioned in the “Visionaries” Quadrant of the Magic Quadrant for Wireless LAN Infrastructure
8. Regular exercise reduces large number of health risks including dementia and some cancers
9. Number of Uninsured American Adults Hits Record High
10. 4,000 numbers crunchers count on Austin
11. University of Miami receives grant to increase the number of family nurse practitioners
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... 2016 , ... Quality metrics are proliferating in cancer care, and are derived ... eye of the beholder, according to experts who offered insights and commentary in the ... Care. For the full issue, click here . , For the American Society ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... was developed to enhance the health of felines. The formula is all-natural and is ... herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American ... Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. ... including advance care planning, healthcare costs and patient and family engagement. , AIR ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture ... said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package ... Final Cut Pro X . Simply select a ProHand generator and drag it ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... recover from injury. Recently, he has implemented orthobiologic procedures as a method for ... is one of the first doctors to perform the treatment. Orthobiologics are substances ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Roche (SIX: RO, ROG; ... for its Elecsys BRAHMS PCT (procalcitonin) assay as a ... septic shock. With this clearance, Roche is the first ... integrated solution for sepsis risk assessment and management. ... infection and PCT levels in blood can aid clinicians ...
(Date:6/23/2016)... Capricor Therapeutics, Inc. ... company focused on the discovery, development and commercialization ... in its ongoing randomized HOPE-Duchenne clinical trial (Halt ... its 24-patient target. Capricor expects the trial to ... 2016, and to report top line data from ...
(Date:6/23/2016)... -- Bracket , a leading clinical trial technology and ... platform, Bracket eCOA (SM) 6.0, at the 52 nd ... 2016 in Philadelphia , Pennsylvania.  A demonstration ... of its kind to fully integrate with RTSM, will be ... is a flexible platform for electronic clinical outcomes assessments that ...
Breaking Medicine Technology: