Navigation Links
'Magic number' 695 opens up new areas for Alzheimer's research
Date:11/15/2010

Alzheimer's disease is widely believed to be caused by the gradual accumulation in the brain of amyloid-beta peptide which is toxic to nerve cells. Amyloid beta peptide is formed from a protein known as APP, which is found in three forms. Most research into APP a key area of study for the disease does not distinguish between the different forms of the protein.

The findings, published in the Journal of Biological Chemistry, show that amyloid beta peptide is actually created mainly by just one form of APP known as APP695 for the number of its amino acids. APP695 is found at greater concentration in brain and nerve cells, but this study funded by the Medical Research Council and the Alzheimer's Research Trust is the first time the significance of that has been shown. This discovery will now enable research to focus more clearly on the exact mechanism by which amyloid beta peptide accumulates in the brain.

"Research into amyloid beta peptide has been going on for more than 20 years and while treatments have made it to clinical trials, nothing has proved truly effective against this disease," says Professor Tony Turner, from Leeds' Faculty of Biological Sciences, who co-led the research. "This could be because research to date has been a bit of a blunt instrument: scientists have essentially been working on too broad a field. Our findings will allow researchers to target their work much more precisely."

The study of APP695 also led the scientists to identify a potential new factor in the development of Alzheimer's. When APP is broken down, it forms another protein called AICD. The researchers discovered that AICD formed from APP695 switches on certain genes within nerve cells that may then damage the cell. The process is unique to nerve cells and AICD formed from the other forms of APP does not have this effect.

"AICD has been detected before, but because studies haven't differentiated between the different forms of APP, there was
'/>"/>

Contact: Prof Nigel Hooper
n.m.hooper@leeds.ac.uk
44-113-343-3163
University of Leeds
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Vitamin D No Magic Bullet for Osteoarthritis
2. Magic Mushroom Hallucinogen Might Help Cancer Patients
3. Nautilus IDScan.net Presents New Drivers' License Parsing Component, a Magic Tool for Software Developers
4. Guardian Preservation Services Responds to Receiving the "National Home Pro of the Year Award" by ServiceMagic
5. Arsa Offers High Quality Supplements, Cosmetics and Magic Scents from Mexico for Less Than $10
6. A magical way to move kids
7. Aerohive Positioned in the “Visionaries” Quadrant of the Magic Quadrant for Wireless LAN Infrastructure
8. Regular exercise reduces large number of health risks including dementia and some cancers
9. Number of Uninsured American Adults Hits Record High
10. 4,000 numbers crunchers count on Austin
11. University of Miami receives grant to increase the number of family nurse practitioners
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... York, NY (PRWEB) November 28, 2014 ... physical therapy techniques such as Dynamic Neuromuscular Stabilization, ... and gait/motion analysis. After moving to upgraded facilities ... and running clinic. Now, owner Dr. Lev Kalika ... performance and injury prevention lab in the country. ...
(Date:11/28/2014)... Agein.com, the Internet’s premier anti-aging web site focusing ... foremost experts in the industry, is releasing its top diet ... , “The official start of winter is still three weeks ... with an icy blast. After one of the worst winters ... usher in another brutal winter,” says Dr. Kevin J. McLaughlin, ...
(Date:11/28/2014)... Junk-A-Car ( http://www.junkacar.com ), one of the ... to help drivers, especially those in and around the ... areas deal with the especially harsh winter weather that ... the country. , With the high number of reported ... crashed and junk cars, Junk-A-Car is voluntarily ...
(Date:11/28/2014)... Mequon, Wisconsin (PRWEB) November 28, 2014 ... facial plastic surgeons , announced the expansion of Quintessa ... new center will be located at W307 N1497 Golf ... 2015. , According to Dr. Campbell, the new Delafield ... non-surgical procedures for patients, including: Botox, filler ...
(Date:11/28/2014)... 2014 Secura Consultants, based in ... marketing organizations in the country focused on delivering ... marketplace. Secura Consultants is proud to offer complimentary ... Group, a leading global financial company. , Many ... the ownership interest comes the need for business ...
Breaking Medicine News(10 mins):Health News:New York Dynamic Neuromuscular Rehabilitation Opens Nation's Most Advanced Movement Performance and Injury Prevention Lab 2Health News:New York Dynamic Neuromuscular Rehabilitation Opens Nation's Most Advanced Movement Performance and Injury Prevention Lab 3Health News:Agein Corporation, a Leading Anti-Aging Company, Releases Top Diet and Personal Care Tips for Preventing Dry Skin this Season 2Health News:Junk-A-Car Expanding Service to Assist U.S. Car Owners That May be Affected by Severe Winter Storms 2Health News:Dr. Andrew Campbell to Expand Quintessa Aesthetic Center into Delafield 2Health News:Secura Consultants Offers Complimentary Buy-Sell Agreement Reviews 2
... -- Some women who inherit the BRCA1 or BRCA2 breast ... with breast cancer nearly a decade earlier than those who ... Researchers examined the family trees of 128 breast or ... determine the origins of the patients, cancer genes. "No ...
... around the world are reporting they are burned out and ... Pennsylvania School of Nursing,s Center for Health Outcomes and Policy ... Between 20 to 60 percent of nurses reported ... International Journal for Quality in Health Care , which ...
... of South American songbirds completed by the Department of ... Natural History, has discovered these birds differ dramatically in ... which indicates they are on the road to becoming ... show that species could change, that they were not ...
... Copenhagen have explored the active principles of a Danish mushroom ... particularly toxic towards cancer cells. The goal is to synthesise ... in future drug development. Asia has a long ... products. Many substances found in fungi are today registered as ...
... INDIANAPOLIS -- The health care system in the United States ... to the bedside, how to ensure more equitable use of ... how to pay for that care. The 10th ... of the journal Medical Care tackles key conceptual ...
... Over the past quarter century in Australia, cancer incidence rates ... are some of the findings of a recent study published ... Compared with any other disease group, cancer has ... two Australians developing cancer and one in five dying from ...
Cached Medicine News:Health News:Family Tree May Affect Diagnosis Age in Some Breast Cancers 2Health News:To keep nurses, improve their work environments 2Health News:Danish mushroom inspires cancer researchers 2Health News:Danish mushroom inspires cancer researchers 3Health News:Journal supplement presents strategies for introducing health care delivery innovation 2Health News:Study sheds light on cancer burden in Australia 2
(Date:11/28/2014)... QC , Nov. 28, 2014 /CNW Telbec/ - Ergoresearch ... and known under the « Équilibre, orthèses et ... Ended on September 30, 2014. All dollar amounts in the ... for the first quarter of fiscal year 2015 ended this ... by 2,1 % compared to revenues of $ 4 227 942 ...
(Date:11/28/2014)... LOS ANGELES , Nov. 28, 2014 According ... Americans over the course of their lifetime. For many, these ... chronic pain that is caused by a variety of factors. ... disc, surgery may be the best option. While there are ... Laser Discectomy performed by Seyed M. Rezaian , M.D., ...
(Date:11/28/2014)... Nov. 28, 2014  Valeant Pharmaceuticals International, Inc. ... announced that its wholly owned subsidiary, Valeant Pharmaceuticals ... of its outstanding 6.875% Senior Notes due 2018, ... on December 29, 2014 and has mailed an ... the redemption, approximately US$500 million aggregate principal amount ...
Breaking Medicine Technology:First Quarter Results fiscal year ended September 30, 2015 - Ergoresearch reports its results for the quarter ended September 30, 2014. 2First Quarter Results fiscal year ended September 30, 2015 - Ergoresearch reports its results for the quarter ended September 30, 2014. 3First Quarter Results fiscal year ended September 30, 2015 - Ergoresearch reports its results for the quarter ended September 30, 2014. 44 Advantages of Laser Back Surgery When Fixing a Herniated Disk 2Valeant Announces Redemption of US$445.0 Million Aggregate Principal Amount of its Outstanding 6.875% Senior Notes due 2018 2
... fewer products in the pipeline and more at the ... commercial life of mature brands are critical to today,s ... as many as 10 years and billions of dollars ... To help biopharmaceutical companies more effectively ...
... Mass., Feb. 24, 2012  Haemonetics Corporation (NYSE: HAE ... Company effective March 5, 2012 as Vice President of ... ) Mr. Helsel, age 48, was with ... was Vice President of Operations for the Surgical Solutions ...
Cached Medicine Technology:Report Delivers ROI Analysis on Key Lifecycle Management Strategies Utilized by the Pharmaceutical Industry 2Dave Helsel Joins Haemonetics as Vice President of Global Manufacturing 2
... Aerosol Resistant Tips offer a safe alternative ... are designed for applications such as PCR(a), ... addition, ART Tips are excellent for tissue ... studies. ART Tips prevent aerosol contaminants and ...
... LBP Processor is a primary component of ... accessioning, processing, sampling, and slide preparation ... The MonoPrep LBP Processor produces high-quality sample ... broad range of cytology specimen types. It ...
... Like all Gilson disposable ... in a sterilized version. Each ... in medical device-quality plastic to ... Sterilization is guaranteed by the ...
200 L, Racked, Pre-sterilized, 96 tips/rack Recommended for 20, 25, 50, 100 and 200 L pipettes. Can also be used with 300 L pipettes when pipetting 200 L or less....
Medicine Products: