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'Magic Mushroom' Compound Triggered Positive Personality Change in Study
Date:9/29/2011

By Alan Mozes
HealthDay Reporter

THURSDAY, Sept. 29 (HealthDay News) -- In new research that will almost certainly create controversy, scientists working with the hallucinogen psilocybin -- the active ingredient found in "magic mushrooms" -- have found that a single dose of the drug prompted an enduring but positive personality change in almost 60 percent of patients.

Specifically, tests involving a small group of patients in a strictly controlled and monitored clinical setting revealed that, more often than not, one round of psilocybin exposure successfully boosted an individual's sense of "openness." What's more, the apparent shift in what is deemed to be a key aspect of personality did not dissipate after exposure, lasting at least a year and sometimes longer.

"Now this finding is really quite fascinating," said study author Roland R. Griffiths, a professor in the departments of psychiatry and neuroscience at Johns Hopkins University School of Medicine in Baltimore. "And that is because personality is considered a stable characteristic of the psychology of people. It's been thought to be relatively immutable, and stable across the lifespan.

"But, remarkably, this study shows that psilocybin actually changes one domain of personality that is strongly related to traits such as imagination, feeling, abstract ideas and aesthetics, and is considered a core construct underlying creativity in general," he added. "And the changes we see appear to be long-term."

Griffiths said it's possible psilocybin could have therapeutic uses. For example, he is currently studying whether the hallucinogen might be useful in helping cancer patients cope with the depression and anxiety that often accompany the disease, and whether it might help smokers quit the habit.

Griffiths and his colleagues discuss their findings, funded in part by the U.S. National Institute on Drug Abuse, in the new issue of the Journal of Psy
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