Navigation Links
Macrophage-derived mediators may have potential as biomarkers for urinary stone risk
Date:10/1/2013

Arnhem, 30 September 2013- A balance between the activation of the inflammatory macrophages and suppression of the anti-inflammatory macrophages in the kidney may play a pivotal role in kidney stone formation. These macrophage-derived mediators may have potential as biomarkers to reflect the urinary stone risk, according to a new study from Japan, which was recently presented at the recent 2nd Meeting of the EAU Section of Urolithiasis and received Clinical Research Award.

Compared to that of control subjects, the urine from individuals with a history of kidney stone formation showed significantly increased levels of the inflammatory chemokines GRO and CXCL1, and significantly decreased levels of IL-4, an anti-inflammatory cytokine involved in macrophage migration. According to Dr. Dr. Atsushi Okada, of Nagoya City University in Japan, this research deals with some very important issues in the field of urolithiasis.

"To date, the risk evaluation and the preventive index of kidney stone formation have been dependent on urinary inorganic matter such as calcium, phosphorus, magnesium, uric acid, oxalate and citrate. However, stone formers don't often show such an abnormality," he explained.

"In a series of preceding studies, we examined organic substance in kidney stones, such as protein from kidney tissue, and revealed that stone matrix and genetic environment of renal tubular cells are as important as urinary inorganic condition for kidney stone formation."

"In the past we have also shown that in mice, certain regulatory mechanisms protect against urinary calcium oxalate stone formation, and that these mechanisms may be mediated by anti-inflammatory Type 2 macrophages (M2s). However, regulatory roles of M2 macrophages in urinary stone formation in humans have not been studied."

This latest study aimed to identify urinary M2 macrophage-associated markers, by performing multiplex urinalysis in individuals prone to developing calcium oxalate kidney stones. The authors were able to observe that stone-formers had a higher level urinary M1 markers, whereas non-stone formers had a higher level of M2 markers.

Dr. Okada believes that this study may have pronounced implications for clinical practice.

"If the usefulness of these macrophage markers is established, it will be possible to evaluate kidney stone risk not only through inorganic but also some organic substances. Furthermore, these results may lead to the development of new therapeutic drugs for kidney stone formation to control macrophage function.


'/>"/>

Contact: Evgenia Starkova
e.starkova@uroweb.org
31-263-890-680
European Association of Urology
Source:Eurekalert

Related medicine news :

1. Repurposed antidepressants have potential to treat small-cell lung cancer
2. Quadruple Amputee and Champion Athlete Kyle Maynard to Inspire Special Needs Kids to Meet Greatest Potential
3. Warning of potential side effects of a product can increase its sales
4. McKenzie Management Develops New Tool To Measure Hidden Revenue Potential
5. Potential treatment for a specific kind of pancreatic cancer
6. Approved cancer drug potentially could help treat diabetes, Stanford researchers find
7. Potential Drug AMG Services LDL Reduction, Declared "New Hope" by Home And Recreation Lifestyle Magazine
8. The Holistic Sanctuary Recognizes International Overdose Awareness Day by Citing CIR Report About Potential Fraud at Conventional Drug Rehab Centers
9. Medical Researchers Say They Have Made a Breakthrough That Could Lead to a Potential Cure for AIDS
10. Paducah, KY Gum Disease Treatment can Now Potentially Reduce Risk of Low Birth Weight by Removing Gum Disease in Expecting Mothers with Dr. Kelvin White
11. Researchers Discover a Potential Cause of Autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... MA (PRWEB) , ... June 23, 2017 , ... ... Care Reconciliation Act (BCRA), their proposed healthcare bill to repeal and replace the ... May, the Senate bill would make significant cuts to Medicaid, a public health ...
(Date:6/23/2017)... ... June 23, 2017 , ... Everybody has their own personal preference when ... read it, and some people don't like it at all. FindaTopDoc took a look ... , Erotic literature can give readers a taste of their deepest, darkest fantasies and ...
(Date:6/23/2017)... ... June 23, 2017 , ... 21 Middle East and South Asia Leaders Selected ... from government, business and civil society in 11 countries across the Middle East and ... in a transformative exchange of knowledge and ideas with the leading minds in their ...
(Date:6/23/2017)... ... June 23, 2017 , ... Ulster University, Magee Campus in Northern Ireland is ... 3 pm to present to graduate students exciting new and innovative hope research based ... led by The Health Improvement Service of the Western Health & Social Care Trust ...
(Date:6/23/2017)... ... June 23, 2017 , ... Moore Insurance, an eastern Texas ... to asset protection and financial planning services, is teaming up with the For ... of children with cancer and other chronic diseases. , The For A Day ...
Breaking Medicine News(10 mins):
(Date:6/5/2017)... 2017 The Cincinnati location ... Inc. (NYSE: DPLO), has been awarded a Top Workplaces ... Results are based on an employee survey administered by ... workplace improvement. The survey measures several aspects of workplace culture, ... ...
(Date:6/3/2017)... -- Eli Lilly and Company (NYSE: LLY ... 3 MONARCH 2 study showed that abemaciclib, a ... with fulvestrant, significantly improved progression-free survival (PFS) compared ... hormone-receptor-positive (HR+), human epidermal growth factor receptor 2-negative ... progressed after endocrine therapy (median PFS, 16.4 vs. ...
(Date:6/1/2017)... , June 1, 2017 Nutriceutical Holdings (NH), ... Recommended Solutions (VRS), and KD Pharma Group have decided ... Holdings by KD Pharma Group. KD Pharma Group will ... option to acquire the entire company. "We ... They are committed to growing the NH companies by ...
Breaking Medicine Technology: