Navigation Links
Macrophage-derived mediators may have potential as biomarkers for urinary stone risk
Date:10/1/2013

Arnhem, 30 September 2013- A balance between the activation of the inflammatory macrophages and suppression of the anti-inflammatory macrophages in the kidney may play a pivotal role in kidney stone formation. These macrophage-derived mediators may have potential as biomarkers to reflect the urinary stone risk, according to a new study from Japan, which was recently presented at the recent 2nd Meeting of the EAU Section of Urolithiasis and received Clinical Research Award.

Compared to that of control subjects, the urine from individuals with a history of kidney stone formation showed significantly increased levels of the inflammatory chemokines GRO and CXCL1, and significantly decreased levels of IL-4, an anti-inflammatory cytokine involved in macrophage migration. According to Dr. Dr. Atsushi Okada, of Nagoya City University in Japan, this research deals with some very important issues in the field of urolithiasis.

"To date, the risk evaluation and the preventive index of kidney stone formation have been dependent on urinary inorganic matter such as calcium, phosphorus, magnesium, uric acid, oxalate and citrate. However, stone formers don't often show such an abnormality," he explained.

"In a series of preceding studies, we examined organic substance in kidney stones, such as protein from kidney tissue, and revealed that stone matrix and genetic environment of renal tubular cells are as important as urinary inorganic condition for kidney stone formation."

"In the past we have also shown that in mice, certain regulatory mechanisms protect against urinary calcium oxalate stone formation, and that these mechanisms may be mediated by anti-inflammatory Type 2 macrophages (M2s). However, regulatory roles of M2 macrophages in urinary stone formation in humans have not been studied."

This latest study aimed to identify urinary M2 macrophage-associated markers, by performing multiplex urinalysis in individuals prone to developing calcium oxalate kidney stones. The authors were able to observe that stone-formers had a higher level urinary M1 markers, whereas non-stone formers had a higher level of M2 markers.

Dr. Okada believes that this study may have pronounced implications for clinical practice.

"If the usefulness of these macrophage markers is established, it will be possible to evaluate kidney stone risk not only through inorganic but also some organic substances. Furthermore, these results may lead to the development of new therapeutic drugs for kidney stone formation to control macrophage function.


'/>"/>

Contact: Evgenia Starkova
e.starkova@uroweb.org
31-263-890-680
European Association of Urology
Source:Eurekalert

Related medicine news :

1. Repurposed antidepressants have potential to treat small-cell lung cancer
2. Quadruple Amputee and Champion Athlete Kyle Maynard to Inspire Special Needs Kids to Meet Greatest Potential
3. Warning of potential side effects of a product can increase its sales
4. McKenzie Management Develops New Tool To Measure Hidden Revenue Potential
5. Potential treatment for a specific kind of pancreatic cancer
6. Approved cancer drug potentially could help treat diabetes, Stanford researchers find
7. Potential Drug AMG Services LDL Reduction, Declared "New Hope" by Home And Recreation Lifestyle Magazine
8. The Holistic Sanctuary Recognizes International Overdose Awareness Day by Citing CIR Report About Potential Fraud at Conventional Drug Rehab Centers
9. Medical Researchers Say They Have Made a Breakthrough That Could Lead to a Potential Cure for AIDS
10. Paducah, KY Gum Disease Treatment can Now Potentially Reduce Risk of Low Birth Weight by Removing Gum Disease in Expecting Mothers with Dr. Kelvin White
11. Researchers Discover a Potential Cause of Autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... ... January 24, 2017 , ... OMI Industries, a worldwide ... a distribution partnership with Byers Scientific & Manufacturing , a leading designer, ... the agreement, OMI Industries formulated a special version of Ecosorb® for Byers Scientific ...
(Date:1/24/2017)... ... ... This Saturday, January 28, the BCFA presents more than 20 local performances including Chinese ... Yifan Zhou, Mara McClain & Sarah Nordlund Dennis. Local chefs and restaurants provide a ... Chinese games, crafts & more. Festivities begin at 11:00 am and end at 2:30 ...
(Date:1/24/2017)... ... January 24, 2017 , ... The results from the ... everyone and particularly good news for prostate cancer patients: incidents of cancer is down ... to the report the cancer death rate has dropped from its peak of 215.1 ...
(Date:1/24/2017)... ... January 24, 2017 , ... Today, Taza ... latest award-winning bottles, designed specifically to optimize the drinking experience for K-Cup coffee, ... renowned for introducing the world’s first untouched bottled water purposed exclusively for creating ...
(Date:1/24/2017)... ... January 24, 2017 , ... “Choosing ... like finances, friendship, marriage, leadership, gossip, prostitution, adultery, anger, and common sense. ... Dr. Judith Coats and Dr. David Coats. In September of 1983, they flew ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)...  In a major study released this weekend ... 1 ( http://www.multivu.com/players/English/7899551-nephrocheck-test-acute-kidney-injury-outcomes/ ), Astute ... identified patients at high risk of Acute Kidney ... randomized control trial led by Alexander Zarbock ... institution,s standard of care or a treatment per ...
(Date:1/24/2017)... Jan. 24, 2017 When tragedy strikes, victims often can,t ... what conditions they have, and who back home is wondering about ... ones informed about the safety of their family and friends, while ... victims in times of crisis. ... If you find yourself or your family in one ...
(Date:1/24/2017)... 2017 Market Research Future has a half cooked research ... market for Plastic Surgery & Integumentary System is growing rapidly and ... forecasted period. Market Highlights ... Global Plastic Surgery & Integumentary System Market has ... market will reach high growth figures and thriving in the coming ...
Breaking Medicine Technology: