Navigation Links
MU researchers show potential for new cancer detection and therapy method
Date:4/22/2010

University of Missouri School of Medicine scientists explain a potentially new early cancer detection and treatment method using nanoparticles created at MU in an article published in the Proceedings of the National Academy of Sciences. The article illustrates how engineered gold nanoparticles tied to a cancer-specific receptor could be targeted to tumor cells to treat prostate, breast or lung cancers in humans.

"When injected into the body, the Gastrin Releasing Peptide (GRP) cancer receptor serves as a signaling device to the gold nanoparticle, which allows for targeted delivery to the tumor site," said Kattesh Katti, PhD, who wrote the article with Raghuraman Kannan, PhD. "Consequently, the radiotherapeutic properties of such nanoparticles also provides valuable imaging and therapeutic tools that can be used for early cancer detection and therapy in various human cancers."

Because GRP receptor mediated imaging and the radiotherapy specifically targets cancer cells, patients could benefit from a more effective treatment with fewer side effects. GRP receptors are abundant in prostate, breast and small lung cancer cells, and the effectiveness of Katti and Kannan's gold nanoparticles has been proved in numerous studies.

"The development of GRP-receptor specific gold nanoparticles and proof of cancer receptor specificity in living subjects, as described by Drs. Katti and Kannan, is a significant and critical step toward the utility of engineered gold nanoparticles in molecular imaging and therapy of various cancers," said Institute of Medicine member Sanjiv Sam Gambhir, MD, PhD, Virginia and D. K. Ludwig Professor, as well as director of the Molecular Imaging Program and Canary Center for Cancer Early Detection at Stanford University.

Katti, Kannan, and others with the MU School of Medicine Department of Radiology have been researching the development of tumor specific gold nanoparticles for more than five years.

"This discovery presents a plethora of realistic opportunities for clinical translation, not only in the development of nanomedicine-based diagnostic technologies for early stage detection but also for therapies for treating tumors in prostate, breast and small cell lung cancer," Kannan said.

Kannan and Katti have developed a library of more than 85 engineered nanoparticles for use in molecular imaging and therapy. With scientists at the MU Research Reactor (MURR), the most powerful university reactor in the world, they have developed cancer specific therapeutic radioactive gold nanoparticles. MURR is one of only a few sites worldwide able to produce cancer targeting gold nanoparticles.


'/>"/>

Contact: Laura Gerding
GerdingLA@health.missouri.edu
573-882-9193
University of Missouri-Columbia
Source:Eurekalert  

Related medicine news :

1. UCSF Researchers Identify Regulator of Human Sperm Cells
2. Researchers find broad spectrum antiviral that fights multitude of viruses
3. University of Alberta researchers develop drug interface to save lives
4. Caregivers of ICU patients are collateral damage of critical illness, say Pitt researchers
5. Researchers fight world hunger by mapping the soybean genome
6. HIV researchers solve key puzzle after 20 years of trying
7. UC Davis researchers identify brain protein for synapse development
8. UCLA cancer researchers perform complete genomic sequencing of brain cancer cell line
9. Researchers find new way to study how enzymes repair DNA damage
10. UCLA researchers image earliest signs of Alzheimers, before symptoms appear
11. Researchers find leukemia cells metabolize fat to avoid cell death
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
MU researchers show potential for new cancer detection and therapy method
(Date:10/13/2017)... Rock, AR (PRWEB) , ... October 13, 2017 ... ... firm with locations throughout Arkansas that offers insurance and financial preparation services, is ... benefit the Rock City Rescue organization. , Rock City Rescue is a locally ...
(Date:10/13/2017)... Nevada (PRWEB) , ... October 13, 2017 , ... ... Hemp CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil ... required and providing a CBD form that can be easily incorporated into liquid products, ...
(Date:10/13/2017)... , ... October 13, 2017 , ... The Visiting Nurse ... Market. Featuring a collection of specialty vendors and unique items from across the nation, ... quality-focused health and wellness services offered by the VNA. The boutique will be ...
(Date:10/13/2017)... ... 13, 2017 , ... Coveros, a leader in agile coaching ... contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile ... of Agile methodologies in a consistent and high value manner across CMS programs. ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of ... announced today its plans to open a flagship location in Covington, LA at 401 ... Rooms To Go store next to Office Depot in the Holiday Square shopping center. ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), a leading ... announced that its MyDario product is expected to appear on The Dr. ... The Dr. Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. Oz Show ... The segment ...
(Date:9/22/2017)... , Sept. 22, 2017  As the latest Obamacare ... Bill Cassidy (R-LA) and Lindsey Graham ... that the medical device industry is in an odd ... tax, the 2.3% excise tax on medical device sales ... also want covered patients, increased visits and hospital customers ...
(Date:9/18/2017)... , Pa. and KALAMAZOO, Mich. , Sept. ... Penn. , and OptiMed Specialty Pharmacy of ... partnership to offer a strategic hub service that expedites ... highly sought-after personal spirometer, Spiro PD 2.0, and wellness ... A spirometer is a medical device used to measure ...
Breaking Medicine Technology: