Navigation Links
MU researchers find synthetic RNA lessens severity of fatal disease
Date:11/21/2011

COLUMBIA, Mo. A team of University of Missouri researchers have found that targeting a synthetic molecule to a specific gene could help the severity of the disease Spinal Muscular Atrophy (SMA) the leading genetic cause of infantile death in the world.

"When we introduced synthetic RNA into mice that carry the genes responsible for SMA, the disease's severity was significantly lowered," said Chris Lorson, researcher at the Bond Life Sciences Center and professor in the Department of Veterinary Pathobiology and the Department of Molecular Microbiology and Immunology. "The mice that receive synthetic RNA gain more weight, live longer, and had improvements in motor skills. These results are very exciting."

SMA is a rare genetic disease that is inherited by one in 6,000 children, who often die young because there is no cure. Children who inherit SMA are missing a gene that produces a protein which directs nerves in the spine to give commands to muscles. Lorson's lab focuses on targeting a partially functioning back-up copy of the missing gene, known as SMN-2, into producing the needed protein.

While the results are promising, Lorson notes additional research is needed before synthetic RNA could be used on humans for SMA. Clinical trials for similar synthetic RNAs are currently being performed in other neurodegenerative disease such as Lou Gehrig's or ALS. In SMA, there are clinical trials taking place in many labs across the country that are investigating drug compounds to increase SMN-2 protein production.

"It's been remarkable to watch how quickly SMN-2 knowledge has transformed from basic molecular biology to being modified targets for novel therapeutics," Lorson said. "SMN-2 is like a light that's been dimmed, and we're trying anything to get it brighter. Even turning it up a little bit would help dramatically."


'/>"/>

Contact: Steven Adams
AdamsST@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert

Page: 1

Related medicine news :

1. Researchers search for culprit behind dry eyes, mouths and more
2. MU researchers develop tool that saves time, eliminates mistakes in diabetes care
3. Researchers discover new way to form extracellular vesicles
4. Researchers discover Achilles heel in lethal form of prostate cancer
5. Jackson Laboratory researchers uncover steps in synapse building, pruning
6. UCLA stem cell researchers uncover mechanism that regulates human pluripotent stem cell metabolism
7. Ben-Gurion University of the Negev researchers achieve male fertility breakthrough
8. Canadian researchers find potential new leukemia treatment with old antibiotic drug
9. FDA funds Rochester researchers to give chronic and acute pain clinical trials a makeover
10. Jefferson researchers study outcomes of carotid artery stenting following prior carotid procedure
11. Researchers gain insight into 100-year-old Haber-Bbosch process
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... Omaha, NE (PRWEB) March 27, 2015 Ticket ... tickets at the CenturyLink Center in Omaha, Nebraska on ... a possibility that more concert dates will be added in ... result of fan demand. , The Garth Brooks World Tour ... with the latest announcement that Garth Brooks and Trisha Yearwood ...
(Date:3/27/2015)... (PRWEB) March 27, 2015 According to ... http://www.idataresearch.com ), the plate and screw market in Europe ... the generic plate and screw segment. Price decreases are ... Despite representing almost 50% of the total European trauma ... decrease the total market value, year after year. ...
(Date:3/27/2015)... LONDON, UK (PRWEB) March 27, 2015 ... SiteStart Melissa (Liss) Easy was named to the 2015 ... 40 Under 40 list spotlights 40 dynamic, up-and-coming leaders ... accomplishments and community involvement. Winners are honored at an ... supplement of the Philadelphia Business Journal. , Lyn Kremer, ...
(Date:3/27/2015)... On March 19, 2015, at Detroit’s ... wide receiver Herman Moore, hosted “Fighting Addiction Together,” ... abuse, treatment options and the recent changes in ... ministers and bishops from local churches as well ... “Our ‘Fighting Addiction Together’ luncheon was informative and ...
(Date:3/27/2015)... CA (PRWEB) March 27, 2015 Endure ... Yoga for functional fitness athletes. This new program matches ... specific protocol for post-workout cool down. This program utilizes ... breath control and mental focus. , Karen Lefurgy, ... started practicing yoga long before I started Crossfit® training, ...
Breaking Medicine News(10 mins):Health News:Cheap Garth Brooks Tickets for CenturyLink Center in Omaha: Ticket Down Slashes Garth Brooks Concert Tickets in Omaha, NE at the CenturyLink Center 2Health News:Cheap Garth Brooks Tickets for CenturyLink Center in Omaha: Ticket Down Slashes Garth Brooks Concert Tickets in Omaha, NE at the CenturyLink Center 3Health News:Titanium Trauma Treatment Devices in Europe Becoming More Affordable, Decreasing Market Value: Group Purchasing Further Eroding Selling Prices 2Health News:Titanium Trauma Treatment Devices in Europe Becoming More Affordable, Decreasing Market Value: Group Purchasing Further Eroding Selling Prices 3Health News:DrugDev Founder Melissa Easy is 2015 Philadelphia Business Journal 40 Under 40 Honoree 2Health News:LiveToBeSober.org Hosts Conference on Substance Abuse Treatment and Recovery at Ford Field 2Health News:Endure Yoga Introduces WOD Recovery Yoga 2
... In medical breakthrough research findings, researchers have been able ... which had significant brain degeneration. ,Researchers from University ... so that the mice have a clinical condition very ... researchers used transgene to check the loss of memory. ...
... form of the enzyme aldehyde dehydrogenase// (ALDH)that is responsible ... consuming alcohol. ,Researchers from Mitsukoshi Health and Welfare ... to hangovers in individuals who have a particular genetic ... important enzyme involved in the removal of acetaldehyde, which ...
... women with sexual difficulties was rejected by a panel of ... ,Procter & Gamble, global manufacturer of household products, ... menopausal after ovarian surgery however due to the rejection by ... hold until more data is available to assess the drug. ...
... a “black box warning” to three asthma drugs//, ... advised the manufacturers that the drug should carry ... breathing. ,Adavir and Serevent are manufactured ... manufacturers the drug Foradil which contains a different ...
... constantly coming up with new strategies// and technologies to ... ,Deputy director BK Karna of Indian Institute ... bring in novel features to prevent proliferation of duplicated ... closure and tamper evidence packaging they are yet to ...
... University of California-San Francisco has published that weight loss// ... by increasing heart beat rate and blood pressure. ... homeostasis. ,The study spearheaded by Dr. Christine A. ... experimental group of 16 healthy adults. Two tests were ...
Cached Medicine News:Health News:Testosterone patch for women Rejected For safety Reasons 2Health News:FDA gives “black box warning” against three asthma dru 2Health News:The Use of Radio Frequency Identification ( RFID) to tackle the growing menace of counterfeit drugs 2
(Date:3/27/2015)... According to a new market ... Advanced, Ultrasound), Ablation Catheter (Cryoablation, RF, Microwave), Lab Devices ... WPW) - Global Forecasts to 2019 ", published by MarketsandMarkets, ... ~$4.73 Billion by 2019 with a CAGR of around ... Browse   90   ma rket ...
(Date:3/27/2015)... , March 27, 2015 As ... shipments of incontinence devices for women. ... the most gratifying part is the hundreds of ... women whose lives have been positively impacted by ... of InControl. InControl recently released Apex, ...
(Date:3/27/2015)... The International Myeloma Foundation (IMF) – improving ... toward prevention and a cure – today commended Representative ... resolution (H. Res. 174) that supports the designation of ... Awareness Month." Currently there are more than ... 110,000 new cases are diagnosed yearly, according to the ...
Breaking Medicine Technology:Electrophysiology (EP) Market Worth $4.73 Billion by 2019 2Electrophysiology (EP) Market Worth $4.73 Billion by 2019 3Electrophysiology (EP) Market Worth $4.73 Billion by 2019 4InControl Medical Surpasses 40,000 Shipments Of Incontinence Devices For Women 2The International Myeloma Foundation (IMF) Secures the Introduction of a Federal Resolution Recognizing March 2015 as "National Multiple Myeloma Awareness Month" 2
... May 5 OrthoAccel Technologies, Inc. announced that it has entered ... to introduce the AcceleDent System to the Australian market. , ... (Logo: http://www.newscom.com/cgi-bin/prnh/20091029/DA01250LOGO ) , ... AcceleDent, an acceleration device to enhance orthodontics, was introduced ...
... Instrumentation Laboratory (IL) today announced total worldwide sales in 2009 ... growth v. previous year in current, and 13.2% in local currencies.  In ... growth in local currencies was 13.2% and 12.4%, respectively. , ... "In spite of the major economic downturn, ...
Cached Medicine Technology:OrthoAccel Technologies, Inc. and AB Orthodontics Announce Partnership and Australian Product Introduction 2OrthoAccel Technologies, Inc. and AB Orthodontics Announce Partnership and Australian Product Introduction 3OrthoAccel Technologies, Inc. and AB Orthodontics Announce Partnership and Australian Product Introduction 4Instrumentation Laboratory Achieves Record Sales in 2009 2Instrumentation Laboratory Achieves Record Sales in 2009 3
... OraQuick is an FDA ... venipuncture whole blood test used ... of HIV-1 infection. This CLIA ... presence of antibodies to HIV-1, ...
... QuickVue+ Infectious Mononucleosis test is ... antibodies in serum, plasma or whole ... utilizes an extract of bovine erythrocytes ... specificity than similar extracts prepared from ...
... the first available point-of-care diagnostic test that ... of influenza A and B. The test ... an enzyme that assists viral replication by ... infected cells. The ZstatFlu substrate is labeled ...
The NOW Flu A test is the most frequently adopted rapid flu test on the market today. Testing could not be easier and the results are available in 15 minutes. Now you can focus on the results and tre...
Medicine Products: