Navigation Links
MU researchers find clue to cataract formation

COLUMBIA, Mo. It is the No. 1 line-item cost of Medicare reimbursement and affects more than 20 million people in the United States. Cataracts, which can have devastating effects on the eye, affect 42 percent of the population between the ages of 70 and 80, and 68 percent of the population over the age of 80, according to the National Eye Institute. Now, a University of Missouri professor has identified an important step in how cataracts form. This discovery, published in a recent edition of The Journal of Biological Chemistry, could lead to a better treatment or cure for cataracts in the future.

In his study, K. Krishna Sharma, professor of ophthalmology at MU, found that a specific type of protein begins to lose function as the eye ages. As the protein loses function, small peptides, made of 10 to 15 amino acids, start forming and accelerate cataract formation in the eye.

It is very helpful to track the formation of these peptides, Sharma said. The next step is to work on preventing their formation. If we are successful, we could delay the aging process in the eye. A ten-year delay in the onset of cataracts could decrease the number of cataract surgeries by 45 percent, thus significantly decreasing vision care cost. Currently, 1.5 million to 2 million cataract surgeries are completed yearly.

About 50 percent of the lens is made of proteins, and 90 percent of the proteins are structures known as crystallins. One of the main functions of the crystallins is to maintain the clarity of the lens through an activity known as chaperoning. In a healthy eye, crystallins break down over time, eventually degrading to small peptides. The peptides are then cleared from the eye with the help of other proteins.

As the eye ages, small peptides start to form at an increasing rate. As the number of small peptides increases in the eye, chaperone activity starts to decrease, resulting in less cleansing activity inside the lens. As the small peptides increase, the eyes lens starts to develop cataracts. There are a variety of causes that lead to the decrease of chaperone activity, and the presence of these small peptides accelerates the process, Sharma said.

Its a very sad situation, because cataracts can have a huge impact on the quality of a persons life, Sharma said. People lose the ability to appreciate visual art and have to learn a new set of skills to navigate. This study will bring us another step closer to understanding how cataracts form in the eye and how best to treat this debilitating disease.

Approximately 50 percent of cataract formation in older individuals is age related, but other risk factors include genetics, smoking, exposure to UV light and diabetes. According to the National Eye Institute, symptoms of early cataracts may be improved with new eyeglasses, brighter lighting, anti-glare sunglasses or magnifying lenses. If these measures do not help, surgery is the only effective treatment. Surgery involves removing the cloudy lens and replacing it with an artificial lens.


Contact: Christian Basi
University of Missouri-Columbia

Related medicine news :

1. Researchers evaluating food allergy treatment
2. U of M researchers identify process that may help treat Parkinsons, spinal cord injuries
3. OHSU Cancer Institute researchers discover key gene involvement in cancer development
4. Combining liver cancer treatments doubles survival rates, UVA researchers find
5. Leading HIV researchers to collaborate on vaccine development
6. Georgetown researchers find stem cell marker controls 2 key cancer pathways
7. Blood pressure drugs halt pancreatic cancer cell growth, Jefferson researchers find
8. OHSU Cancer Institute researchers find connection between protein, prognosis in breast cancer
9. Karmanos Researchers Report Enhanced Chemosensitivity of Pancreatic Cancer Cells by Black Seed Component
10. Penn researchers find targeted therapy combination overcomes treatment resistance in liver cancer
11. Researchers find disparities in depression among older Hispanics in US
Post Your Comments:
(Date:11/27/2015)... ... 2015 , ... Lizzie’s Lice Pickers just announced a special promotion that will ... their purchase of lice treatment product. In addition, customers will receive a complimentary head ... “Finding lice is a sure way to ruin the holidays, so we encourage all ...
(Date:11/27/2015)... ... 27, 2015 , ... Consistent with the Radiology Business ... Better Radiology Marketing Programs meeting will showcase some of the best 2015 ... Caesars Palace in Las Vegas with a pre-conference session on a collaborative approach ...
(Date:11/27/2015)... ... November 27, 2015 , ... Keeping in ... for mental health and wellness consultation, has collaborated with a leading web-based marketplace ... knowledge gap experienced by parents and bring advice from parenting experts within their ...
(Date:11/27/2015)... California (PRWEB) , ... November 27, 2015 , ... Avid ... Joplin Ann Arbor Michigan boxing style concert posters. This is one of Joplin's most ... the Canterbury House at the University of Michigan in Ann Arbor. The According to ...
(Date:11/26/2015)... and Cambridge, ON (PRWEB) , ... November 26, ... ... the availability of a real-time eReferral system for diagnostic imaging in the Waterloo ... X-rays, mammography, BMD and Nuclear Medicine tests directly from their electronic medical record ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 2015 ) ... "2016 Future Horizons and Growth Strategies in ... Supplier Shares, Country Segment Forecasts, Competitive Intelligence, ... --> ) has announced ... Horizons and Growth Strategies in the French ...
(Date:11/26/2015)... Nov. 26, 2015 Research and Markets ( ... "Advanced Wound Care Market by Type (Dressings, Therapy Devices, ... (In-Patient Facility, Out-Patient Facility), and Geography - Global Forecast ... --> --> The purpose ... and forecast of the global advanced wound care market. ...
(Date:11/26/2015)... Research and Markets ( ) ... Future Horizons and Growth Strategies in the Italian ... Segment Forecasts, Competitive Intelligence, Emerging Opportunities" report ... --> This new 247-page report ... drug monitoring market, including emerging tests, technologies, instrumentation, ...
Breaking Medicine Technology: