Navigation Links
MU researchers find clue to cataract formation
Date:4/17/2008

COLUMBIA, Mo. It is the No. 1 line-item cost of Medicare reimbursement and affects more than 20 million people in the United States. Cataracts, which can have devastating effects on the eye, affect 42 percent of the population between the ages of 70 and 80, and 68 percent of the population over the age of 80, according to the National Eye Institute. Now, a University of Missouri professor has identified an important step in how cataracts form. This discovery, published in a recent edition of The Journal of Biological Chemistry, could lead to a better treatment or cure for cataracts in the future.

In his study, K. Krishna Sharma, professor of ophthalmology at MU, found that a specific type of protein begins to lose function as the eye ages. As the protein loses function, small peptides, made of 10 to 15 amino acids, start forming and accelerate cataract formation in the eye.

It is very helpful to track the formation of these peptides, Sharma said. The next step is to work on preventing their formation. If we are successful, we could delay the aging process in the eye. A ten-year delay in the onset of cataracts could decrease the number of cataract surgeries by 45 percent, thus significantly decreasing vision care cost. Currently, 1.5 million to 2 million cataract surgeries are completed yearly.

About 50 percent of the lens is made of proteins, and 90 percent of the proteins are structures known as crystallins. One of the main functions of the crystallins is to maintain the clarity of the lens through an activity known as chaperoning. In a healthy eye, crystallins break down over time, eventually degrading to small peptides. The peptides are then cleared from the eye with the help of other proteins.

As the eye ages, small peptides start to form at an increasing rate. As the number of small peptides increases in the eye, chaperone activity starts to decrease, resulting in less cleansing activity inside the lens. As the small
'/>"/>

Contact: Christian Basi
BasiC@missouri.edu
573-882-4430
University of Missouri-Columbia
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers evaluating food allergy treatment
2. U of M researchers identify process that may help treat Parkinsons, spinal cord injuries
3. OHSU Cancer Institute researchers discover key gene involvement in cancer development
4. Combining liver cancer treatments doubles survival rates, UVA researchers find
5. Leading HIV researchers to collaborate on vaccine development
6. Georgetown researchers find stem cell marker controls 2 key cancer pathways
7. Blood pressure drugs halt pancreatic cancer cell growth, Jefferson researchers find
8. OHSU Cancer Institute researchers find connection between protein, prognosis in breast cancer
9. Karmanos Researchers Report Enhanced Chemosensitivity of Pancreatic Cancer Cells by Black Seed Component
10. Penn researchers find targeted therapy combination overcomes treatment resistance in liver cancer
11. Researchers find disparities in depression among older Hispanics in US
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... benefits of medical imaging far outweigh the risks when ... with The Right Radiation Dose. However, overuse and misuse ... is leading a collaborative effort to ensure a national ... in the Journal of Patient Safety , calls ... the Intersociety Accreditation Commission, and the Centers for Medicare ...
(Date:7/10/2014)... For decades, health-conscious people around the globe have taken ... this was one of the paths to good health ... trials of antioxidant supplements have repeatedly dashed the hopes ... cancer risk. Virtually all such trials have failed ... fact, in several trials antioxidant supplementation has been linked ...
(Date:7/10/2014)... Men who experience hot flashes are unlikely to talk ... their silent suffering if they are willing to ... Baylor University case study., After seven weeks of hypnotic ... flashes following prostate cancer surgery showed a drastic decrease ... improvement in sleep quality, according to the study., The ...
(Date:7/9/2014)... Vasectomy was associated with a small increased risk of ... lethal prostate cancer according to a new study from ... that the association remained even among men who received ... cancer cannot be explained by diagnostic bias. It is ... look at the link between vasectomy and prostate cancer. ...
(Date:7/9/2014)... of lung cancer, researchers have uncovered mutations in a ... The new knowledge may expand treatments for patients because ... available or are in clinical trials. , Reporting July ... Genome Atlas (TCGA), including researchers at Washington University School ... other institutions, studied tumors from 230 patients with lung ...
Breaking Medicine News(10 mins):Health News:Mayo Clinic calls for standardization of safe imaging protocols for children 2Health News:How antioxidants can accelerate cancers, and why they don't protect against them 2Health News:Men's hot flashes: Hypnotic relaxation may ease the discomfort men don't talk about 2Health News:Men's hot flashes: Hypnotic relaxation may ease the discomfort men don't talk about 3Health News:Men's hot flashes: Hypnotic relaxation may ease the discomfort men don't talk about 4Health News:Vasectomy may increase risk of aggressive prostate cancer 2Health News:Lung cancer study hints at new treatments 2
... , TUESDAY, Jan. 31 (HealthDay News) -- A pre-pregnancy ... moms-to-be will develop gestational diabetes, a new study says. ... proportion of animal fat and cholesterol in their diets ... during pregnancy," senior author Dr. Cuilin Zhang, of the ...
... by older adults is the shared focus of the two ... (GSA) From Publication to Practice series. Together they ... of the most popular pain medications, acetaminophen. Both issues aim ... pain prevention, treatment, and management may improve care and quality ...
... Margaret Farley Steele and Steven Reinberg HealthDay Reporter ... into a genetically mutated form of bird flu could escape ... U.S. scientific advisers to ask two prominent journals to withhold ... So far, so-called H5N1 bird -- or avian -- ...
... Assistant Professor at LSU Health Sciences Center New Orleans Schools ... an article published in the January 28, 2012 issue of ... a void in medical education worldwide leadership. Dr. Gee ... on the inaugural Inter Academy Medical Panel (IAMP) Young Physician ...
... Many employers in the U.S. hospitality industry may be reluctant ... they can,t do the work and that they are more ... University of New Hampshire researchers analyzed data from 320 ... related to the hiring of disabled people. "We found ...
... French . Ottawa, Ontario -- The Harper ... Canadians in getting more effective treatments and make the ... announcement was made by the Honourable Leona Aglukkaq, Minister ... State for Science and Technology. "Our Government is ...
Cached Medicine News:Health News:Fatty Diet Before Pregnancy Linked to Gestational Diabetes 2Health News:New GSA resources lay foundation for relieving seniors' pain 2Health News:U.S. Advisers Explain Request to Censor Bird Flu Research 2Health News:U.S. Advisers Explain Request to Censor Bird Flu Research 3Health News:U.S. Advisers Explain Request to Censor Bird Flu Research 4Health News:Lsuhsc's Gee helping address international medical education leadership void 2Health News:Hospitality Not a Friendly Industry for Disabled Workers: Study 2Health News:Harper government invests in personalized medicine 2
(Date:1/15/2014)... Calif. , Jan. 15, 2014 Massachusetts ... (NASDAQ: AMGN ) announced today that ... discover and validate new therapeutic targets and develop ... chronic disorder that affects millions worldwide. The MGH-Broad-Amgen ...
(Date:1/15/2014)...  In an unprecedented effort to curb the spread of "superbugs" such ... vehicles, an advanced and portable UV germicidal lamp manufactured by MRSA-UV ... In order to prevent EMS paramedics and transport ... West Palm Beach Fire Rescue is the first in ...
(Date:1/15/2014)... , Jan. 15, 2014  According to Millennium ... technology market intelligence, the United States ... (TEO) device markets will expand moderately through 2022, ... segments. In particular, increasing interest in drug-eluting beads ...
Breaking Medicine Technology:Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4Superbugs No Longer Ride In Rescue Vehicles 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3
... May 18, 2011 The Consumer Healthcare Products ... acetaminophen medicines for children, applauds the U.S. Food ... and caregivers give their children the right amount ... Committee and Pediatric Advisory Committee recommended enhancing the ...
... Kinetics, Inc. (NKI) ( www.neuro-kinetics.com ), manufacturers of ... neuro-otologic, vestibular and neurological testing, said today that ... control and analysis software. Clinical specialists ... conduct vestibular, oculomotor and optokinetic tests to detect ...
Cached Medicine Technology:OTC Industry Supports FDA Advisory Committee Recommendations on New Dosing Instructions 2OTC Industry Supports FDA Advisory Committee Recommendations on New Dosing Instructions 3Neuro Kinetics Releases Updated Version of Neuro-Otologic Control and Analysis Software 2
The base of the staple is round and threaded to enable screwing onto the stapler. The base also has spikes. The legs of the staple are contoured to prevent the staple from backing out....
The staple fixation system provides a simple means of attaching tissue to bone....
... ORTHOSET Radiopaque Bone Cement ... system: a sterile,ampule containing bone ... pack, and a sterile polyethylene ... a peelable pouch. The interiors ...
... Cement consists of a two ... bone cement liquid within a ... polyethylene bag,containing bone cement powder ... interiors of the blister pack,and ...
Medicine Products: