Navigation Links
MU awarded $8.5 million to explore tiny vessels' role in cardiovascular diseases
Date:5/6/2010

One of the largest medical research grants ever awarded to the University of Missouri was announced today by MU scientists and administrators. The National Institutes of Health grant will help answer important questions about such prevalent health problems as high blood pressure, diabetes and stroke. The conditions are closely associated with cardiovascular disease, which is the leading cause of death in Missouri and the nation.

The $8.47 million program project grant from the NIH's National Heart, Lung and Blood Institute (NHLBI) will fund an integrated research effort involving more than 20 scientists across campus. Their discoveries will further understanding of the smallest blood vessels in the body, collectively known as the microcirculation. How the miniscule vessels contribute to health and disease is a growing field of study for cardiovascular researchers.

"The grant has given us a very large opportunity that will help us focus on the many questions we have about microvascular function," said Gerald Meininger, PhD, the program director and project principal investigator, as well as director of MU's Dalton Cardiovascular Research Center. "By focusing the efforts of many scientists, we hope to further understand the underlying conditions that contribute to many different types of cardiovascular diseases."

Life literally depends on the microcirculation. The network of vessels, with walls as small as a single cell thick, are responsible for transferring gases, nutrition and hormones throughout the body. The vessels also remove waste, such as carbon dioxide, from organs and tissues. The ability of these processes to function properly, over and over again through many of miles of tiny vessels, is what determines the health of the entire cardiovascular system and all the organs and tissues it supports.

"MU has spent decades developing one of the most productive groups of cardiovascular investigators in the world, with a special emphasis on the emerging field of microcirculation," said Robert Churchill, MD, Hugh E. and Sarah D. Stephenson Dean of the MU School of Medicine. "This grant is the latest example of what MU can achieve when scientific talent and resources from across campus come together to achieve a critical mass in a critical area of medical research."

The grant projects are particularly reliant on scientists and resources at MU's Dalton Cardiovascular Research Center, School of Medicine and College of Veterinary Medicine. Other key collaborators include MU's Center for Gender Physiology and Environmental Adaptation, Cosmopolitan International Diabetes and Endocrinology Center, Charles W. Gehrke Proteomics Center, and research support cores for computing, translational science and electron microscopy. Microscopy and spectrometry technology at Dalton and MU's Christopher S. Bond Life Sciences Center provide advanced tools for high-resolution imaging and analysis.

"The imaging resources give MU a powerful advantage in terms of trying to answer questions about blood vessels that are thinner than human hair, as well as cells and tissues," said Ronald Korthuis, PhD, chair of the Department of Medical Pharmacology and Physiology and a project leader for the grant. "Where others can only speculate, we are able to show the world."

All of the project leaders in the program grant are faculty members in the MU School of Medicine Department of Medical Pharmacology and Physiology, which is ranked 12th in the nation in terms of research grant funding. The prominence of Dalton and the department in microcirculation research led to MU's selection as host for more than 150 scientists from around the world for a meeting of the Microcirculatory Society in October 2009.

The pharmacology and physiology department also is generously supported by private gifts for endowed faculty positions and research centers. Grant program director Meininger, project leader Michael Davis, PhD, and George Davis, MD, PhD, and other department scientists involved in the grant are Margaret Proctor Mulligan Distinguished Professors in Medical Research. Korthuis, a project leader, is the George L. and Melna A. Bolm Distinguished Professor in Cardiovascular Health. Center for Gender Physiology director Virginia Huxley, PhD, is the James O. Davis Distinguished Professor in Cardiovascular Research. She and other scientists are housed in the Thomas W. and Joan F. Burns Center for Diabetes and Cardiovascular Research.

"These endowments helped transform MU into a highly competitive institution for cardiovascular research," said Chancellor Brady Deaton, PhD, who recently led MU in receiving more than $1 billion in gifts for a campuswide fundraising campaign. "With this new NIH grant, we'll continue to leverage our significant investments in cardiovascular research to improve the health and quality of life for people across our state and throughout the world."


'/>"/>

Contact: Laura Gerding
gerdingla@health.missouri.edu
573-882-9193
University of Missouri-Columbia
Source:Eurekalert

Related medicine news :

1. Carol Milgard Breast Center Awarded Highest Government Rating for Mammography Sites
2. Prominent Beverly Hills Law Firm Awarded $16.5 Million Medical Malpractice Jury Verdict
3. pcRUSH.com / Atman, Inc. is Awarded General Services Administration (GSA) Schedule (GS-35F-0099W)
4. $12 Million American Recovery and Reinvestment Act Grant Awarded to Urban Health Plan, Inc. (UHP)
5. Jefferson awarded multi-million dollar NIH grant
6. Orsi Awarded First Place for Procedure with Embozene(TM) Microspheres
7. Tender Corp.'s HealthiFeet Awarded American Podiatric Medical Association Seal of Approval
8. UM Clinical Research Building awarded prestigious LEED Building Certification
9. TeamStaff Awarded $3.3 Million Contract
10. Mimotopes Awarded a Major Peptide Library Supply Agreement by La Jolla Institute for their Studies Screening Dengue and Tuberculosis Pathogens
11. €1.6 million ($2.32 million) grant awarded to Prof. Kobi Rosenblum for brain and memory research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... cutting edge technology to revolutionize the emergency ambulance transport experience for the millions ... aware of how Uber has disrupted the taxi industry through the use of ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a ... can give their videos a whole new perspective by using the title layers ... Film Studios. , ProSlice Levels contains over 30 Different presets to choose from. ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American Institutes ... Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , ... advance care planning, healthcare costs and patient and family engagement. , AIR researchers ...
(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
(Date:6/25/2016)... ... 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s a ... the bar too high can result in disappointment, perhaps even self-loathing. However, those who ... , Research from PsychTests.com reveals that behind the tendency to set ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...  Arkis BioSciences, a leading innovator in the ... cerebrospinal fluid treatments, today announced it has secured ... led by Innova Memphis, followed by Angel Capital ... Arkis, new financing will accelerate the commercialization of ... of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... startling report released today, National Safety Council research shows ... plan to eliminate prescription opioid overdoses. Prescription Nation ... the worst drug crisis in recorded U.S. history, assigned a "Making ... , New Mexico , Tennessee ... states, three – Michigan , Missouri ...
(Date:6/23/2016)... Bracket , a leading clinical trial technology and specialty ... Bracket eCOA (SM) 6.0, at the 52 nd ... in Philadelphia , Pennsylvania.  A demonstration of ... its kind to fully integrate with RTSM, will be held ... a flexible platform for electronic clinical outcomes assessments that is ...
Breaking Medicine Technology: