Navigation Links
MSU team studies connection between statins, tendon ruptures

EAST LANSING, Mich. Michigan State University researchers are studying the role that statins lifesavers for tens of millions of Americans trying to lower their cholesterol play in causing disabling tendon ruptures.

Francesca Dwamena, an associate professor in the College of Human Medicine's Department of Medicine, is leading the study, which will analyze more than 100,000 Blue Care Network enrollees. The study is funded by a grant from the Blue Cross Blue Shield of Michigan Foundation.

"Statins are such commonly prescribed medications, and the number of statin-users is on the rise," Dwamena said. "It is important for physicians and patients to be aware of all the risks. We need to find out definitively if statins predispose patients to this disabling complication."

While lowering cholesterol, statins also inhibit certain proteins that are required for remodeling of tendons, she said. Without remodeling, tendons become very prone to injury and potential rupture.

Dwamena and her team seek to confirm the findings from a pilot study that found increased tendon ruptures in women. Before that study, statin-induced tendon rupture was only described in case reports and post-marketing studies. With a large population-based outlook, the researchers also will assess the effects of dose, duration and type of statin on tendon rupture.

Blue Care Network enrollees between 2000 and 2009 will be included. The research team which also includes Joseph Gardiner, chairperson of MSU's Department of Epidemiology, and internal medicine residents Abhimanyu Beri and Tahmeed Contractor already has identified more than 30,000 statin users. They will be compared to more than 60,000 non-users.

Tom Fraser, a project manager at Blue Care Network, is helping with data extraction. The analysis is expected to take about one year.

This funding was obtained through the Blue Cross Blue Shield of Michigan Foundation's "Physician Investigator Initiated Research Award Program." The award provides $10,000 in seed money to investigate important issues related to the health and medical care of Michigan residents.


Contact: Jason Cody
Michigan State University

Related medicine news :

1. New Scientific Studies Show Further Evidence of Avandia Dangers
2. University of Utah Announces New Studies on the Benefits of Treadmill Desks
3. Barrow researchers receive more than $2 million in NIH grants for nicotine studies
4. Studies Show Doctors Rapidly Forget Critical, Life-Saving Skills such as CPR and Life Support
5. PRA International Rolls out Client Access to Oracle(R) RDC for Early Phase Studies
6. Genomic Health to Present Five New Studies at 32nd Annual San Antonio Breast Cancer Symposium
7. Studies Quantify Cancer Risks From CT Scans
8. Brandeis studies evaluate visionary approach to improving eyesight
9. Ninety Percent of All Vaccine Preventable Deaths Occur in Those 65 and Older According to Highlighted Studies in the December Patient Safety Advisory
10. Acuo Technologies Announces a New Offering That Enables Sharing of Imaging Studies Securely and Affordably
11. Mimotopes Awarded a Major Peptide Library Supply Agreement by La Jolla Institute for their Studies Screening Dengue and Tuberculosis Pathogens
Post Your Comments:
(Date:11/30/2015)... , ... November 30, 2015 , ... ... at a University of Delaware Accounting and Management of Information Systems course. Based ... for mid-market businesses. Sommer will speak at before student in the Enterprise Resource ...
(Date:11/30/2015)... , ... November 30, 2015 , ... ... continuing education course in Dallas, TX, on January 29 and 30, 2016. The ... improve the functions of their practices, to learn how to better succeed in ...
(Date:11/30/2015)... PA (PRWEB) , ... November 30, 2015 , ... A ... 15th annual Regional Biotech Conference, organized by the Baruch S. Blumberg Institute. , The ... 100 of the area’s life science and biotechnology leaders for the conference, which focused ...
(Date:11/30/2015)... ... November 30, 2015 , ... HemoTreat™ has announced ... its hemorrhoid ointment to its website. , “Our goal is simple:” says Michael ... hemorrhoids. Adding the comparison chart and ingredient list allows our customers to quickly ...
(Date:11/30/2015)... ... November 30, 2015 , ... ChiliPad , Chili ... maximize recovery through quality sleep. Tim DiFrancesco, training coach for the LA Lakers, ... sleep. ChiliPad precisely regulates the surface temperature of each side of the bed ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... Nov. 30, 2015  PTS Diagnostics, the U.S.-based manufacturer ... analyzers, A1CNow ® systems, and PTS Detect™ ... of patents that will propel the company into the ... Europe . The technology is a ... those on smartphones and tablets, and uses test strip ...
(Date:11/30/2015)... , Nov. 30, 2015 Cumberland Pharmaceuticals (CPIX), ... present live at on December 3, 2015. ... TIME: 3:15p.m. ET LINK: ... LINK: --> ... event where investors are invited to ask the company questions ...
(Date:11/30/2015)... LAKE CITY , Nov. 30, 2015 Booth ... (NYSE: VAR ) will exhibit a broader array of ... of the Radiological Society of North America ... Varian exhibit at the meeting will feature X-ray components "At ... CT tube, a line of products from Varian,s Claymount brand, ...
Breaking Medicine Technology: