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MSU researchers make new discoveries on what does and doesn't affect immune system
Date:2/4/2008

blood cell produced in bone marrow that fights infection by making antibodies.

"This is a brand new role for leptin," said Fraker. "It appears that most obese people may be somewhat immunosuppressed. This finding shows us that the body's resistance to leptin plays a role in that, too."

To further study leptin's effect on the immune system, Fraker and her colleagues are planning a study on morbidly obese people who will be having gastric bypass surgery. While the outcome of the surgery is highly successful for most people, mortality rates can range from 2 to 10 percent, which is significant.

"Infection from poor wound healing, which is the result of reduced immune function, is one reason people die from the surgery," Fraker said. "We're going to measure people's immune function before and after surgery to see how much it improves, as well as how fast it improves."

Other members of this research team are MSU scientists Louis King, research assistant professor of biochemistry and molecular biology, and Kate Claycombe, assistant professor of food science and human nutrition.

Naturally-produced steroids don't inhibit immune system

While corticosteroids, such as prednisone, reduce inflammation, they also inhibit the body's immune system -- a person taking prescription steroids is more susceptible to infection. Another MSU research team found that corticosteroids produced naturally in the body don't have this same immunosuppressive effect.

The human body secretes corticosteroids when it's under stress, both psychological and physical, and these steroids are responsible for the "fight-or-flight response" in humans and other animals. Cortisol (also called hydrocortisone) is the most abundant corticosteroid in the body. These steroids' anti-inflammatory effects are well-known and pharmaceutical companies have been making versions of them for about 20 years. But people taking steroids are warned that cuts and br
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Contact: Pam Fraker
fraker@msu.edu
517-353-3513
Michigan State University
Source:Eurekalert

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