Navigation Links
MSU researcher links cholesterol crystals to cardiovascular attacks
Date:3/26/2009

EAST LANSING, Mich. --- For the first time ever, a Michigan State University researcher has shown cholesterol crystals can disrupt plaque in a patient's cardiovascular system, causing a heart attack or stroke.

The findings by a team led by George Abela, chief of the cardiology division in MSU's College of Human Medicine, could dramatically shift the way doctors and researchers approach cardiovascular attacks. Abela's findings appear in the April issue of the American Journal of Cardiology.

"Any time there is something completely new or unique in medical research, it is met with healthy skepticism," said Abela, who has been working with cholesterol crystals since 2001. "But we have found something that can help dramatically change how we treat heart disease."

What Abela and his team found is that as cholesterol builds up along the wall of an artery, it crystallizes from a liquid to a solid state and then expands.

"As the cholesterol crystallizes, two things can happen," Abela said. "If it's a big pool of cholesterol, it will expand, causing the 'cap' of the deposit to tear off in the arterial wall. Or the crystals, which are sharp, needle-like structures, poke their way through the cap covering the cholesterol deposit, like nails through wood."

The crystals then work their way into the bloodstream. It is the presence of this material, as well as damage to an artery, that disrupts plaque and puts the body's natural defense mechanism -- clotting -- into action, which can lead to dangerous, if not fatal, clots.

Abela and his team studied coronary arteries and carotid plaques from patients who died of cardiovascular attacks. When comparing their findings against a control group, they found evidence of cholesterol crystals disrupting plaque.

The breakthrough in discovering the crystals' impact came after Abela and colleagues found a new way to preserve tissue after an autopsy, using a vacuum dry method instead of an alcohol solution. The previous method would dissolve the crystals and prevent researchers and doctors from seeing the impact.

Abela also has found that cholesterol crystals released in the bloodstream during a cardiac attack or stroke can damage artery linings much further away from the site of the attack, leaving survivors at even greater risk. The research means health care providers now have another weapon in their arsenal against cardiovascular diseases.

"So far, treatments have not been focused on this process," Abela said. "Now we have a target to attack with the various novel approaches. In the past, we've treated the various stages that lead to this final stage, rather than preventing or treating this final stage of the condition."

In separate research published in the March edition of medical journal Atherosclerosis, Abela and colleagues looked at the physical triggers that can cause cholesterol crystallization. They found that physical conditions such as temperature can play a role in how quickly cholesterol crystallizes and potentially causes a rupture.


'/>"/>

Contact: Jason Cody
codyja@msu.edu
517-432-0924
Michigan State University
Source:Eurekalert  

Related medicine news :

1. Three Johns Hopkins researchers named Howard Hughes Medical Institute early career scientists
2. Researchers decipher blood stem cell attachment, communication
3. Researchers studying hearing loss find auditory regions of the brain convert to the sense of touch
4. UIC researchers measure health effects of Chicagos waterways
5. U-M researchers idea jells into potential new disease-detection method
6. Focus on treating malnutrition in cancer patients, researchers say
7. Researchers Suspect Genetic Link to COPD
8. Syracuse University researchers build a new surface material that resists biofilm growth
9. Researchers Use Gene to End High Blood Sugar in Mice
10. Penn researchers identify new protein important in breast cancer genes role in DNA repair
11. Researcher wins $2.6 million grant for depression care study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
MSU researcher links cholesterol crystals to cardiovascular attacks
(Date:9/26/2017)... (PRWEB) , ... September 26, 2017 , ... Ron Norman, ... how to use the Law of Large Numbers in favor of senior, upper-level executive ... Las Vegas casinos, have long understood the Law of Large Numbers as a way ...
(Date:9/26/2017)... (PRWEB) , ... September 26, 2017 , ... As the ... news site, https://dealfeed.sutlr.com . People are constantly trying to find tips and stories ... industry, Sutlr deal feed brings you the top trending deals. The deals are organized ...
(Date:9/26/2017)... Plains, NJ (PRWEB) , ... September 26, 2017 ... ... Fellowship trained orthopedic surgeon and the Chair of the Leg, Ankle, and Foot ... Kovatis is currently the only fellowship trained orthopedic surgeon at Hackensack UMC performing ...
(Date:9/26/2017)... ... 26, 2017 , ... “How to Live in the Millennium”: a gripping take on how ... no longer a part of everyday life and do not affect daily choices. It ... for the thoughts, words, and actions that are chosen. “How to Live in the ...
(Date:9/26/2017)... (PRWEB) , ... September 26, 2017 , ... “Sonflower Submission”: ... a strong-willed nature to the inevitable destinations of negativity, complaining and the need to ... side to take effect in order for a lesson in stress-less living to be ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... TORONTO , Sept. 6, 2017 /PRNewswire/ ... new knowledge and skills while treating their ... for hands-on experience without involving patients. Simulation ... skills. Clinicians can carry out procedures, refine ... at risk. Integration of new technology, such ...
(Date:9/6/2017)... -- NeuroRx, a clinical stage biopharma company developing the first ... been granted Fast Track status by the US Food and ... followed by NRX-101 (D-cycloserine + lurasidone). The company will shortly ... therapy targeting patients who are admitted to Emergency Departments with ... ...
(Date:9/5/2017)... -- Sapheneia and Scannerside received FDA 510(k) clearance to ... third-party Vendor neutral CT product that makes it affordable ... current MITA standards. ... specifically designed to provide CT operators, prior to a ... a predefined threshold. Scannerside Dose Check is intended to ...
Breaking Medicine Technology: