Navigation Links
MSU invention could help pharmaceutical industry save money
Date:4/30/2012

EAST LANSING, Mich. Two Michigan State University researchers have invented a protein purifier that could help pharmaceutical companies save time and money.

The details of the invention, which appear in a recent issue of the journal Langmuir, demonstrate that MSU chemists Merlin Bruening and Greg Baker's high-performance membranes are highly suitable for protein purification, a crucial step in the development of some new drugs.

Purifying proteins, the process of isolating a single, desired protein from all others, is an expensive, time-consuming hurdle that contributes to the high cost of some prescription drugs. Obtaining pure proteins, however, is a necessary step to increasing these drugs' effectiveness and safety. Streamlining the process could help manufacturers reduce costs, speed new drugs to consumers and reduce pharmaceutical costs, Bruening said.

"The membrane devices that we've manufactured can simplify protein purification by rapidly capturing the desired protein as it flows through membrane pores," said Bruening, who has patented the process and is working to scale up his invention. "Our membranes have two to three times more capacity than existing commercial devices, and they should reduce the purification process time substantially. Typically, our procedures are complete in 30 minutes or less."

The pursuit of a comparable, but complex purification procedure led to the discovery of the researchers' simpler invention. Bruening and his colleague were trying to grow extended polymer chains in the membranes in a multistep, oxygen-free process. Untangling the complexities of the first method led to the revelation that direct adsorption of acidic polymers at low pH is much simpler yet accomplishes the same task of creating extended polymer in the pores. (The purifier uses adsorption rather than absorption; the filter attracts contaminants to its surface rather than sucks them up like a sponge.)

"Once our findings began steering us toward the simpler solution, we began developing simple processes to modify membranes by simply flowing polymer solutions through the membranes," Bruening said.

The next challenge for Bruening and his colleagues will be to upscale his invention so that rapid protein purification with inexpensive membranes becomes a standard for not only pharmaceutical companies, but also researchers trying to rapidly isolate proteins to determine their structure and function.


'/>"/>

Contact: Layne Cameron
layne.cameron@ur.msu.edu
517-353-8819
Michigan State University
Source:Eurekalert

Related medicine news :

1. Premature Death Could Await Obese Kids
2. Six Other E. colis Could Be Lurking In Your Valentine Days Dinner
3. Tiny fruit fly could offer big clues in fight against obesity, researcher says
4. New Book Reveals How Qigong Could Be The Eastern Answer To Botox
5. Chocolate lovers could be lowering their risk of stroke: Study
6. Charging less for more effective treatments could reduce health care costs while improving health
7. Clinical trial underway: Miniature ultrasound device could revolutionize pain relief
8. UAB-led study shows simple steps could reduce stillbirths by up to 1 million
9. Most maternal deaths in sub-Saharan Africa could be avoided
10. Dolphins could be ideal model to study human cervical cancer, UF veterinarians say
11. New Technology Could Widen Reach of Vaccines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... , ... February 12, 2016 , ... The Journal ... up from 0.416 in 2013. The SJR uses data taken from the Scopus database ... both the number of citations received by the journal over a three year period ...
(Date:2/11/2016)... ... February 11, 2016 , ... Hall Integrative Health and ... for their simultaneous grand openings in March. All seven practices are set to ... wondering, is reversing diabetes possible? According to this 2011 CNN article it is ...
(Date:2/11/2016)... , ... February 11, 2016 , ... ... Feb. 23 webinar, “Intel’s Direct-to-Employee Benefit Model: A Case Study for Plans and ... health care system that’s partnering with Intel on value-based health benefits program Connected ...
(Date:2/11/2016)... ... , ... PharmMD CEO Robert Yeager announced today ... contract negotiations, corporate strategy and healthcare data law. Additional responsibilities will include healthcare ... breaches for the Part D Star Rating improvement and Medication Therapy Management firm. ...
(Date:2/11/2016)... Long Island, NY (PRWEB) , ... February 11, ... ... (INS) has enhanced and updated its hallmark resource, Infusion Therapy Standards of Practice, ... global leader in vein illumination with an estimated 85% share of the market, ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... ALEX , has taken Kickstarter by storm, crowdfunding over $60,000 – or 120% of its original ... to be delivered to backers starting May of this year. ... ... ... Created by NAMU, a team of biomedical engineers out of ...
(Date:2/11/2016)... ROLLING MEADOWS , Ill. and INDIANAPOLIS ... major milestone for many young people, but for those ... demanding. Not only do these students juggle class schedules, ... challenges of living with type 1 diabetes. On top ... the first time. Diabetes Scholars Foundation ...
(Date:2/11/2016)... Feb. 11, 2016  AbbVie, a global biopharmaceutical ... Scholarship, designed to provide financial support for exceptional ... pursue higher education goals. Fifteen scholars will be ... school year. The AbbVie Rheumatology Scholarship is currently ... vice president, corporate social responsibility, brand and communications, ...
Breaking Medicine Technology: