Navigation Links
MS that runs in families appears more severe than non-familial MS
Date:10/12/2007

BUFFALO, N.Y. -- Magnetic resonance images (MRI) of a large group of patients with multiple sclerosis has provided the first evidence that those with a history of MS in their families show more severe brain damage than patients who have no close relatives with the disease.

The results, based on brain MRIs of 759 consecutive MS patients, support the hypothesis that a patients genetic make-up plays a role not only in development but also in severity of the disease.

A University at Buffalo team of neurologists and imaging experts headed by Robert Zivadinov, M.D., Ph.D., professor of neurology, conducted the research at the Buffalo Neuroimaging Analysis Center (BNAC), which Zivadinov directs. The BNAC is an arm of the Jacobs Neurology Institute, UBs Department of Neurology in the School of Medicine and Biomedical Sciences. Patients were recruited at the Baird MS Center, also part of the Jacobs Neurological Institute.

The research findings were presented today (Friday, Oct. 12) at the 23rd Congress of the European Committee for the Treatment and Research in Multiple Sclerosis in Prague, Czech Republic.

From the early 1980s on, said Zivadinov, MS researchers thought that genetic factors likely played a role in the disease, that its traits were determined by several different genes, and our findings support this hypothesis.

Our MRI analysis showed a difference between the severity of disease characteristics in familial MS patients versus what we call sporadic, or non-familial, MS patients, he said. These differences may be related to some disease-modifying genes, but to prove this, we must do further investigation.

MS destroys myelin, the fatty sheath that protects nerve fibers carrying message traffic from various muscles to and from the central nervous system. For reasons currently unknown, in some people the myelin sheath breaks down, resulting in destruction of the nerve fibers and the symptoms of MS.

This demyelization process leads to mild to serious disability, from slight numbness of the limbs to loss of vision and paralysis.

The cohort of 759 patients involved in the study ranged in age from 36-56, with an average disability score of 3.4 on a scale of 0-10. A higher number indicates more disability.

Of these patients, 478 had relapsing-remitting MS, involving acute attacks with full or partial recovery; 222 had secondary-progressive MS, characterized by occasional attacks and sustained progression; 30 had primary-progressive MS with steady worsening from onset, and 29 had experienced their first attack.

Twenty-six percent, or 198, had a positive family history of MS. The breakdown between first-, second- or third-degree relatives with MS was 81/35/82. All patients obtained full clinical and quantitative MRI evaluations.

Using MRI, researchers measured the number and volume of lesions (plaques), which represent areas of demeylination; atrophy of the whole brain, white matter (the neural pathways), grey matter (brain regions) and the cortex, as well as employing additional imaging techniques.

There were no significant differences between familial and sporadic cases based on age, disease duration, disease course, disability score and total lifetime use of disease-modifying drugs.

Analysis showed that compared to patients with no family history of MS, familial MS patients had significantly more destructed lesions, and significantly lower volume of whole brain, white matter and gray matter, as well as other indications of greater brain degradation.

Patients whose parents, children or siblings [first-degree relatives] had MS showed more damage than patients who had cousins with MS, Zivadinov said. This indicates that the closer the relationship, the greater the risk of MS.

Of particular interest is the finding of more severe gray matter damage and more lesions, particularly in those with MS in first-degree relatives. These findings are very interesting and we will be investigating them further.

Additional researchers on the study from the BNAC and the JNI, were Frederick E. Munschauer, M.D., Nadir Abdelrahman, M.D., Sara Hussein, Jackie Durfee, Barbara E. Teter, Ph.D., David Hojnacki, M.D., Michael G. Dwyer, Jennifer L. Cox, Ph.D., Marlieke De Brujin, Milena Stosic, M.D., Fernando Nussenbaum and Bianca Weinstock-Guttman, M.D.

Murali Ramanathan, Ph.D., from the UB School of Pharmacy and Pharmaceutical Sciences, also contributed to the research.
'/>"/>

Contact: Lois Baker
ljbaker@buffalo.edu
716-645-5000 x1417
University at Buffalo
Source:Eurekalert

Related medicine news :

1. Dysfunctional Families Affect The Mental Health Of The Child
2. Alzheimers with psychosis runs in families
3. Early rising from sleep can run in families
4. Alcohol based sanitizer found to reduce illness in families
5. Kidney failure shows a tendency to run in families
6. Tendency To Smoke and Get Addicted Could Run In Families!
7. Snappy Mobiles Known To Cause Snappish Behavior in Families
8. SIDS On The Rise Among Poor Families
9. BPL Families To Receive Health Insurance: Andhra CM
10. Health Insurance Numbers Declining In American Families
11. Government’s Welfare Plan For Deprived Families Affect Other
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... June 24, 2017 , ... Studies show evidence that carotenoids ... risk of visual loss in these patients. , But how often do ophthalmologists and ... cessation to patients at risk of or with early symptoms of AMD? A ...
(Date:6/23/2017)... ... 23, 2017 , ... Goodcents Deli Fresh Subs today announced the opening of ... SW 21st St. Topeka, Kan. 66604 (near 21st and Gage). It is owned and ... three other locations in the Topeka and Bonner Springs, Kan. area. , “Goodcents ...
(Date:6/23/2017)... Palm Beach, FL (PRWEB) , ... June 23, 2017 , ... ... 19, in Pinecrest, Florida. This is MD Now’s 28th facility overall and marks the ... S. Dixie Highway, located one mile North of The Falls shopping mall. The new ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Katyl Agency, a ... families and business owners in and around Lackawanna County, is joining Meals On ... the area. , Meals on Wheels of NEPA provides hand-delivered and nutritious meals ...
(Date:6/22/2017)... , ... June 22, 2017 , ... Branches, Inc. has ... than $245,000 in grant funding to support its programs focused on providing opportunity to ... was awarded a grant by the Foundation of $15,000 to support its , Climb ...
Breaking Medicine News(10 mins):
(Date:5/30/2017)... , May 30, 2017 Hill-Rom Holdings, Inc. (NYSE: ... Annual Global Healthcare Conference on Tuesday, June 13, 2017, in ... Greisch , Hill-Rom,s president and chief executive officer, is scheduled ... live audio webcast can be accessed at http://ir.hill-rom.com/events.cfm . ... of the live event through September 13, 2017. ...
(Date:5/29/2017)... TEL AVIV, Israel, May 29, 2017  Cellect Biotechnology ... of innovative technology which enables the functional selection of ... financial results for the first quarter ended March 31 ... pleased with our accomplishments in the first quarter of ... the first quarter, we announced the treatment of the ...
(Date:5/26/2017)... BARBARA, Calif. , May 25, 2017  In ... United States , Direct Relief is working with ... overdose-reversing Naloxone available at no cost to community health ... other nonprofit providers nationwide. "Pfizer has ... access to medicines and ensuring patient safety through educational ...
Breaking Medicine Technology: