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MS patients report greater treatment satisfaction with TYSABRI

Atlanta, Ga. May 28, 2009 Biogen Idec (NASDAQ: BIIB) and Elan Corporation, plc (NYSE: ELN) today announced interim results from an ongoing, one-year longitudinal health-outcomes study in which patients reported significantly higher levels of treatment satisfaction after three infusions with TYSABRI (natalizumab) when compared to multiple sclerosis (MS) therapies used previously. The findings from the study, which were reported by patients on therapy, further demonstrate the benefits of TYSABRI in treating MS and are helping to redefine successful treatment of the disease. The study, which was performed in conjunction with HealthCore Inc., a health-outcomes research company, is being presented in a poster today during the 23rd Annual Meeting of the Consortium of Multiple Sclerosis Centers.

"The patients in this study reported significantly greater satisfaction with TYSABRI when compared to their previous MS treatments, which makes these data even more compelling for patients who may not be satisfied with their current treatment," said William Stuart, M.D., medical director of the Multiple Sclerosis Center of Atlanta. "When coupled with previously reported data from this ongoing study that showed overall improvement in quality of life measures, we have a clearer picture of the real-world impact of TYSABRI on MS patients' lives. The success of TYSABRI over the past three years should be an encouragement to move this drug to the forefront of treatment options in many select MS patients."

About the Study

This ongoing study, which is the first attempt to evaluate patient experiences with TYSABRI in usual-care settings, will continue to assess health outcomes from the patients' perspectives, with subsequent data collections, after the sixth and 12th TYSABRI infusions. A total of 1,275 patients were enrolled in the study. Of these patients, 702 completed the third infusion assessment at the time of the analysis. Of the 1,275, there were 224 patients who were still being contacted or had not yet reached their third infusion. Of the initial 1,275; 43 chose to no longer participate in the study, 60 had already received a fourth infusion, 53 were unable to be contacted and 193 discontinued or had never started TYSABRI treatment.

These patient-reported outcomes paint a broad picture of MS patients' ongoing treatment experience, which helps us to measure the effectiveness of MS treatments and expand our understanding of their everyday impact. A majority of the patients in the study are female (78.4%) with a mean age of 45.3 years and mean disease duration of 10 years. Almost all (97%) patients had used at least one MS drug prior to receiving TYSABRI.

Patient satisfaction with treatment was assessed using the Treatment Satisfaction Questionnaire for Medication (TSQM) with higher scores indicating higher satisfaction.

In the study, patients' attitudes towards MS drugs, with respect to effectiveness, convenience and overall satisfaction, at baseline (n=681) were compared to their attitudes to the same measures after three TYSABRI infusions.

As compared to other MS drugs, patients reported statistically significant higher levels of satisfaction after three infusions of TYSABRI with respect to:

  • effectiveness of treatment (baseline 43.9 vs. 63.5 at the third infusion; p< 0.001);
  • convenience of treatment (baseline 58.9 vs. 80.0 at the third infusion; p< 0.001); and
  • global satisfaction (baseline 61.5 vs. 73.8 at the third infusion; p< 0.001).

The poster Treatment Satisfaction with Natalizumab in Multiple Sclerosis Patients (S63) will be available for viewing begining on Thursday, May 28, 2009, 8:00 a.m EDT.


Contact: Shannon Altimari; Biogen Idec
GCI Health

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