Navigation Links
MRI techniques improve pulmonary embolism detection
Date:3/18/2012

OAK BROOK, Ill. New research shows that the addition of two magnetic resonance imaging (MRI) sequences to a common MR angiography technique significantly improves detection of pulmonary embolism, a potentially life-threatening condition traditionally diagnosed through computed tomography (CT). Results of the study are published online in the journal Radiology.

Pulmonary embolism occurs when a blood clotusually from the legtravels to the lung and blocks the pulmonary artery or one of its main branches. CT angiography is the gold standard for diagnosis, but it exposes patients to ionizing radiation and iodinated contrast agent, which carries a risk of allergic reactions and kidney damage in some patients.

"MRI is developing much faster than CT," said Diego R. Martin, M.D., Ph.D., head of the Department of Radiology at the University of Arizona College of Medicine in Tucson. "The images we're getting are already significantly better than they were a year ago. There is no doubt that in the future we will be able to offer a non-radiation-based alternative to CT for the diagnosis of pulmonary embolism."

MRI has been used for pulmonary embolism detection in pregnant women and patients whose kidneys may be harmed by CT angiography contrast agents. However, the Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III) study, a major multicenter trial, found that centers had difficulty obtaining adequate quality MR pulmonary angiography (MRPA) for suspected pulmonary embolism. The PIOPED researchers determined that MRPA should be considered only at centers that routinely perform it and perform it well, and for patients who have contraindications to standard tests.

In the new study, the research team assessed the impact of two additional MRI sequences on MRPA's accuracy. The two techniquescontrast-enhanced volumetric interpolated breath-hold examination (VIBE) and non-contrast true fast imaging with steady-state precession (true FISP)complement MRPA, according to Dr. Martin.

The addition of VIBE provides a gray scale that enables readers to distinguish between the clot, or thrombus, and the lung, which both appear dark on MRPA.

"Also, VIBE is not time sensitive," Dr. Martin said. "If the patient coughs, you can do it again. You don't have that option with MRPA."

The true FISP test does not require contrast agent or a breath hold, an important consideration for embolism patients who often cannot hold their breath long enough for image acquisition on MRPA.

When Dr. Martin and colleagues studied the three techniques on 22 patients with CTA diagnosis of pulmonary embolism, they found a sensitivity of 55 percent, 67 percent and 73 percent for MRPA, true FISP and VIBE, respectively. Combining all three MRI sequences improved the overall detection rate to 84 percent. Specificity was 100 percent for all detection methods except for MRPA, which demonstrated one false positive.

Dr. Martin hopes his findings stimulate discussion of a new, redesigned PIOPED study.

"PIOPED III did not answer the question of whether or not MRI is a useful alternative to CT, because it didn't use all the tools available," he said.

The MRI sequences used in the study are offered on all the major vendor systems, according to Dr. Martin, with the entire three-sequence protocol taking only 15 minutes to set up and perform.


'/>"/>
Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

Related medicine news :

1. New and varied imaging techniques facilitate personalized medicine
2. First report of increased safety using simultaneous techniques for cardiac testing published
3. U of T research shows anti-aging techniques not yet viewed as acceptable
4. Improved radical surgery techniques provide positive outcomes for bladder cancer patients
5. Minimal scar techniques in living donors for kidney transplant
6. Newer techniques are making cardiac CT safer for children
7. Behavioral Techniques a Better Value for Chronic Migraine Than Meds: Study
8. Sandia Labs unlocks secrets of plague with stunning new imaging techniques
9. John Theurer Cancer Center orthopedic oncologist shares new limb sparing surgical techniques
10. New techniques for stapling peptides could spur development of drugs for cancer
11. Less invasive techniques help manage complications of severe pancreatic disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2017)... FL (PRWEB) , ... May 19, 2017 , ... ... feature RawTrition’s BioEnergy in an upcoming episode of Innovations with Ed Begley, Jr., ... Jersey, RawTrition is the distributor of a clean, organic dietary supplement made from ...
(Date:5/19/2017)... (PRWEB) , ... May 19, 2017 , ... The Hill ... to families and entrepreneurs throughout the California Central Valley, is announcing a joint charity ... raising community support for a local kid’s camp event. , The Boys and Girls ...
(Date:5/19/2017)... ... May 19, 2017 , ... ... announced a sponsorship and speaking session at the 7th Annual ET6 Exchange ... hosted enterprise mobility and digital transformation conference whose expressed purpose is to connect ...
(Date:5/19/2017)... ... 2017 , ... CloSYS products which are marketed as the gentle giants of ... and gum health, which is linked to one’s overall health. Since 1991 when the ... powerful ways in which CloSYS products immediately helped eliminate bad breath as well as ...
(Date:5/18/2017)... ... ... Dr. Kim Ross supports Stroke Awareness Month by now accepting new patients ... condition and serious systemic health conditions including heart disease and stroke. Those with bleeding ... and seeking treatment with Dr. Ross immediately may prevent bacteria from spreading. , ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... SAN DIEGO , May 4, 2017 ... 2017 Annual Clinical and Scientific Meeting— OBP Medical , ... devices, today announced the launch of a new extra-small ... and ER-SPEC vaginal specula. Already available ... and extra-large sizes makes OBP Medical,s line of single-use ...
(Date:5/3/2017)... , May 3, 2017 A ... any hospital or healthcare facility. Commonly referred to ... is equipped with diagnostic imaging technology to give ... the heart. In these spaces, a team of ... balloon angioplasty, percutaneous coronary intervention, congenital heart defect ...
(Date:5/2/2017)... WASHINGTON and NEW YORK ... 2017 As the leading distributor of market ... with European Med Tech Reimbursement Consulting AB ... Med Tech Reimbursement Consulting AB,s proprietary market analyses through ... business professionals around the world easy access to complete ...
Breaking Medicine Technology: