Navigation Links
MRI study finds that depression uncouples brain's hate circuit
Date:10/4/2011

A new study using MRI scans, led by Professor Jianfeng Feng, from the University of Warwick's Department of Computer Science, has found that depression frequently seems to uncouple the brain's "Hate Circuit". The study entitled "Depression Uncouples Brain Hate Circuit" is published today (Tuesday 4th October 2011) in the journal Molecular Psychiatry.

The researchers used MRI scanners to scan the brain activity in 39 depressed people (23 female 16 male) and 37 control subjects who were not depressed (14 female 23 male). The researchers found the fMRI scans revealed significant differences in the brain circuitry of the two groups. The greatest difference observed in the depressed patients was the uncoupling of the so-called "hate circuit" involving the superior frontal gyrus, insula and putamen. Other major changes occurred in circuits related to risk and action responses, reward and emotion, attention and memory processing.

The hate circuit was first clearly identified in 2008 by UCL Professor Semir Zeki who found that a circuit which seemed to connect three regions in the brain (the superior frontal gyrus, insula and putamen) when test subjects were shown pictures of people they hated.

The new University of Warwick led research found that in significant numbers of the depressed test subjects they examined by fMRI that this hate circuit had become decoupled. Those depressed people also seemed to have experienced other significant disruptions to brain circuits associated with; risk and action, reward and emotion, and attention and memory processing. The researchers found that in the depressed subjects:

  • The Hate circuits were 92% per cent likely to be decoupled
  • The Risk/Action circuit was 92% likely to be decoupled
  • The Emotion/Reward circuit was 82% likely to be decoupled

Professor Jianfeng Feng, from the University of Warwick's Department of Computer studies said that:

"The results are clear but at first sight are puzzling as we know that depression is often characterized by intense self loathing and there is no obvious indication that depressives are less prone to hate others. One possibility is that the uncoupling of this hate circuit could be associated with impaired ability to control and learn from social or other situations which provoke feelings of hate towards self or others. This in turn could lead to an inability to deal appropriately with feelings of hate and an increased likelihood of both uncontrolled self-loathing and withdrawal from social interactions. It may be that this is a neurological indication that is more normal to have occasion to hate others rather than hate ourselves."


'/>"/>

Contact: Professor Jianfeng Feng
jianfeng.feng@warwick.ac.uk
86-135-247-20112
University of Warwick
Source:Eurekalert  

Related medicine news :

1. HPV-Linked Oral Cancers on the Rise, Study Finds
2. Early, Intensive Therapy Better for Kids With Autism, Study Finds
3. Study gauges emotional toll of direct-to-consumer genetic testing
4. General Anesthesia Does Not Boost Cancer Risk, Study Finds
5. New study finds familiarity increases the fullness that children expect from snack foods
6. Mayo Clinic study: multiple surgeries and anesthesia exposure
7. UNC shares $6 million Leducq award to study heart failure
8. Study shows young adults want to recover from addiction but need help to make it happen
9. Early to bed and early to rise -- study suggests its keeping kids leaner
10. No One Treatment for Acid Reflux Clearly Better Than Another: Study
11. Otherwise Healthy Older Men Undertreated for Prostate Cancer: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
MRI study finds that depression uncouples brain's hate circuit
(Date:2/8/2016)... ... 2016 , ... Stephanie Hebert Insurance Agency, serving families of ... charity campaign. As part of their ongoing community involvement program, funds are now ... children deserve a voice, and in the spirit of neighbors helping neighbors in ...
(Date:2/8/2016)... , ... February 08, 2016 , ... A man who has struggled to quit smoking, ... Laser Therapy , was determined to find solutions to his problems – and he did. ... Digest is ready to introduce his breakthrough inventions to the world and better people's ...
(Date:2/8/2016)... York, NY (PRWEB) , ... February 08, 2016 , ... ... are too much to handle, you are not alone. According to the Center for ... include heart disease, stroke, type 2 diabetes and certain types of cancer, some of ...
(Date:2/8/2016)... Hilton Head Island, SC (PRWEB) , ... February 08, 2016 , ... ... Head and surrounding areas with a vital new community enrichment program, has teamed up ... to local women and children suffering from intimate abuse. To support all those victimized ...
(Date:2/8/2016)... ... February 08, 2016 , ... Local ... the greater Venice, FL area, has initiated a fundraiser for a two year ... just four days after Christmas. To support this beautiful child who is facing ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... Cardiovascular Surgery Devices - Medical Devices Pipeline Assessment, ... report, "Cardiovascular Surgery Devices - Medical Devices Pipeline ... Devices currently in pipeline stage. ... comprehensive information on the pipeline products with comparative ... development. The report reviews major players involved in ...
(Date:2/8/2016)... 2016  Labvantage Lx, a newcomer to the ... sexual enhancement product, EnduramenT. Setting a new standard ... a patented biomedical breakthrough molecule that promotes the ... responsible for many biological functions including erectile function. ... Forgoing the use of prescription medications, scientists working ...
(Date:2/8/2016)... TOKYO and FAIRFIELD, N.J. ... (Otsuka) and Medimetriks Pharmaceuticals, Inc. (Medimetriks) today announced that ... exclusive development and commercialization rights for OPA-15406 in the ... agreement also provides manufacturing rights.  OPA-15406 is a topical, ... for atopic dermatitis. --> ...
Breaking Medicine Technology: