Navigation Links
MRI study finds that depression uncouples brain's hate circuit
Date:10/4/2011

A new study using MRI scans, led by Professor Jianfeng Feng, from the University of Warwick's Department of Computer Science, has found that depression frequently seems to uncouple the brain's "Hate Circuit". The study entitled "Depression Uncouples Brain Hate Circuit" is published today (Tuesday 4th October 2011) in the journal Molecular Psychiatry.

The researchers used MRI scanners to scan the brain activity in 39 depressed people (23 female 16 male) and 37 control subjects who were not depressed (14 female 23 male). The researchers found the fMRI scans revealed significant differences in the brain circuitry of the two groups. The greatest difference observed in the depressed patients was the uncoupling of the so-called "hate circuit" involving the superior frontal gyrus, insula and putamen. Other major changes occurred in circuits related to risk and action responses, reward and emotion, attention and memory processing.

The hate circuit was first clearly identified in 2008 by UCL Professor Semir Zeki who found that a circuit which seemed to connect three regions in the brain (the superior frontal gyrus, insula and putamen) when test subjects were shown pictures of people they hated.

The new University of Warwick led research found that in significant numbers of the depressed test subjects they examined by fMRI that this hate circuit had become decoupled. Those depressed people also seemed to have experienced other significant disruptions to brain circuits associated with; risk and action, reward and emotion, and attention and memory processing. The researchers found that in the depressed subjects:

  • The Hate circuits were 92% per cent likely to be decoupled
  • The Risk/Action circuit was 92% likely to be decoupled
  • The Emotion/Reward circuit was 82% likely to be decoupled

Professor Jianfeng Feng, from the University of Warwick's Department of Computer studies said that:

"The results are clear but at first sight are puzzling as we know that depression is often characterized by intense self loathing and there is no obvious indication that depressives are less prone to hate others. One possibility is that the uncoupling of this hate circuit could be associated with impaired ability to control and learn from social or other situations which provoke feelings of hate towards self or others. This in turn could lead to an inability to deal appropriately with feelings of hate and an increased likelihood of both uncontrolled self-loathing and withdrawal from social interactions. It may be that this is a neurological indication that is more normal to have occasion to hate others rather than hate ourselves."


'/>"/>

Contact: Professor Jianfeng Feng
jianfeng.feng@warwick.ac.uk
86-135-247-20112
University of Warwick
Source:Eurekalert  

Related medicine news :

1. HPV-Linked Oral Cancers on the Rise, Study Finds
2. Early, Intensive Therapy Better for Kids With Autism, Study Finds
3. Study gauges emotional toll of direct-to-consumer genetic testing
4. General Anesthesia Does Not Boost Cancer Risk, Study Finds
5. New study finds familiarity increases the fullness that children expect from snack foods
6. Mayo Clinic study: multiple surgeries and anesthesia exposure
7. UNC shares $6 million Leducq award to study heart failure
8. Study shows young adults want to recover from addiction but need help to make it happen
9. Early to bed and early to rise -- study suggests its keeping kids leaner
10. No One Treatment for Acid Reflux Clearly Better Than Another: Study
11. Otherwise Healthy Older Men Undertreated for Prostate Cancer: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
MRI study finds that depression uncouples brain's hate circuit
(Date:10/13/2017)... ... ... On The Brink”: the Christian history of the United States and the loss of ... William Nowers. Captain Nowers and his wife, Millie, have six children, ten grandchildren, ... Navy. Following his career as a naval aviator and carrier pilot, he spent ...
(Date:10/12/2017)... ... 2017 , ... The company has developed a suite of ... authorities worldwide. From Children’s to Adults 50+, every formula has been developed by ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, Preservative ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... drug delivery system that we intend to develop to enable prevention of a ... lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, the Health & Wellness ... Moonlight to raise money for the American Heart Association Heart Walk. Teams of up ... work together to keep their treadmills moving for 5 hours. Treadmills will start at ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... in wound care advancements to physician colleagues, skilled nursing facility medical directors and ... the Treacherous Waters of Wound Care." , "At many of these conferences we ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... -- AVACEN Medical , Inc. (AVACEN) announced that Frost ... Product Innovation Award for Its fibromyalgia pain management device. ... device market research by Frost & Sullivan,s industry experts. ... relief product, the AVACEN 100, offers a safe and effective ... ...
(Date:10/11/2017)... Texas , Oct. 11, 2017  Caris Life ... focused on fulfilling the promise of precision medicine, today ... has joined Caris, Precision Oncology Alliance™ (POA) as its ... cancer centers, the St. Jude Crosson Cancer Institute will ... advance the use of tumor profiling, making cancer treatment ...
(Date:10/10/2017)... EXTON, Pa. , Oct. 10, 2017   ... leader in innovative solutions for injectable drug administration, today ... of West,s ID Adapter for improving the intradermal administration ... the Fourth Skin Vaccination Summit in May 2017 by ... Team Lead, Polio Department, World Health Organization (WHO), and ...
Breaking Medicine Technology: