Navigation Links
MRI may contribute to early detection of Alzheimer's
Date:4/11/2011

OAK BROOK, Ill. (April 11, 2011) New research suggests that magnetic resonance imaging (MRI) could help detect Alzheimer's disease (AD) at an early stage, before irreversible damage has occurred, according to a new study published online and in the June print edition of Radiology.

With no known treatment to alter its course, AD exacts an enormous toll on society. The Alzheimer's Association estimates that 5.4 million Americans are living with the disease today, and the cumulative costs for care could top $20 trillion over the next four decades. As a result, there is growing interest in tests that could identify individuals at risk for AD at an early stage, when memory preservation may still be possible. Brain volume measurement with MRI is one promising area of research.

"One of the things that made our study novel was that we looked at patients who were cognitively normal at baseline, rather than people with mild cognitive impairment," said lead author Gloria C. Chiang, M.D., radiology resident at University of California San Francisco.

For the study, researchers looked at whether automated brain volume measurements on MRI could accurately predict future memory decline in elderly people with normal cognitive ability. They assessed 149 participants with an initial baseline MRI scan and a neuropsychological assessment.

Follow-up exams two years later showed that 25 of the 149 initially cognitively normal participants, or 17 percent, had memory decline.

While previous research has focused on the medial temporal lobe of the brain, which is strongly associated with memory, researchers looked at volume changes across a number of regions in the temporal and parietal lobes. The parietal lobe is primarily associated with the processing of sensory information and is involved in a number of cognitive and language processes.

The predictive accuracy of the classification model increased as the number of brain regions included in the model increased. Models that took into account several areas of both the temporal and parietal lobes had an 81 percent accuracy rate in discriminating between cognitively normal people with and without memory decline.

The findings illuminated how the interaction between these brain regions may play a key role in memory loss.

"Previous models have included regions of the brain as isolated variables," Dr. Chiang said. "Our study showed that volume loss in multiple regions that may be interconnected had a greater impact on memory decline. We found that automated temporal and parietal volumes identified those at risk for future memory decline with high accuracy."

The study represents another step in the process of incorporating imaging into the diagnosis and management of Alzheimer's disease, according to Dr. Chiang.

"We can see so much with MRI, but right now there's no way to definitively diagnose AD with imaging," she said. "The goal in the future is to have a screening device to monitor cognitive decline and diagnose AD."


'/>"/>

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

Related medicine news :

1. Sleep issues contribute to cognitive problems in childhood cancer survivors
2. Micro-RNAs contribute to risk for panic disorder
3. Antioxidants in pecans may contribute to heart health and disease prevention
4. Warm Homes in Winter May Contribute to Obesity Epidemic
5. Parents Divorce May Contribute to Suicidal Thoughts Years Later
6. Smog Contributes to Dangerous Heart Rhythm Disorders
7. Structure deep within the brain may contribute to a rich, varied social life
8. Citywide smoking ban contributes to significant decrease in maternal smoking, pre-term births
9. Cancer news articles may contribute to confusion about cancer
10. Housing Woes May Contribute to Poor Health
11. Newly discovered regulatory mechanism essential for embryo development and may contribute to cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... 2016 , ... Mercy College is expanding its Graduate Business Programs to the ... due to high demand: Master of Business Administration (MBA), Master of Organizational Leadership (MSOL) ... , School of Business Graduate Program Chair Dr. Ray Manganelli said: “We believe that ...
(Date:4/29/2016)... ... April 29, 2016 , ... Our bodies are bombarded ... to confront and deal with these stressors is to adopt a more healthful diet, ... for you. Risa Groux, a certified Holistic Nutritionist and the creator of the Newport ...
(Date:4/29/2016)... ... 2016 , ... Conditions were ideal for Global Lyme Alliance’s (GLA) 2nd annual ... skies, a light breeze and temperatures in the 60s. Over 400 runners, walkers and ... Walk and 1-mile walk were held to increase awareness about Lyme disease and ...
(Date:4/29/2016)... ... 29, 2016 , ... Mobility Designed is redefining mobility with their patent ... M+D Crutch evenly distributes body weight from the elbow to the forearm. In ... crutches than with other crutches. , Co-founders Max and Liliana Younger were inspired to ...
(Date:4/29/2016)... York, NY (PRWEB) , ... April 29, 2016 , ... New York City based oral ... . This surgery is a very effective way to treat obstructive sleep apnea. Dr. Jamali ... , Orthognathic surgery is a procedure that involves one or both jaw bones. This surgery ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... SAN FRANCISCO , April 27, 2016 /PRNewswire/ ...  is expected to reach USD 2.06 billion by ... View Research, Inc. Increasing consumer awareness towards a ... over the next seven years.      ... Improper diet intake coupled with rising health treatment ...
(Date:4/26/2016)... Mich. , April 26, 2016 Diplomat ... promotion of Jennifer Hagerman , Pharm D., to ... her growing role at Diplomat, Hagerman will continue to ... the company that delivers custom education and training to ... the specialty pharmacy industry. Diplomat University also houses the ...
(Date:4/26/2016)... 2016 US demand for infection prevention ... percent annually to $27.6 billion in 2020.  Increasing ... decrease rates of healthcare-associated infections (HAIs) will boost ... services.  Although declining, the overall rate of certain ... set by the CDC.  Recent statistics indicate that ...
Breaking Medicine Technology: