OAK BROOK, Ill. (April 11, 2011) New research suggests that magnetic resonance imaging (MRI) could help detect Alzheimer's disease (AD) at an early stage, before irreversible damage has occurred, according to a new study published online and in the June print edition of Radiology.
With no known treatment to alter its course, AD exacts an enormous toll on society. The Alzheimer's Association estimates that 5.4 million Americans are living with the disease today, and the cumulative costs for care could top $20 trillion over the next four decades. As a result, there is growing interest in tests that could identify individuals at risk for AD at an early stage, when memory preservation may still be possible. Brain volume measurement with MRI is one promising area of research.
"One of the things that made our study novel was that we looked at patients who were cognitively normal at baseline, rather than people with mild cognitive impairment," said lead author Gloria C. Chiang, M.D., radiology resident at University of California San Francisco.
For the study, researchers looked at whether automated brain volume measurements on MRI could accurately predict future memory decline in elderly people with normal cognitive ability. They assessed 149 participants with an initial baseline MRI scan and a neuropsychological assessment.
Follow-up exams two years later showed that 25 of the 149 initially cognitively normal participants, or 17 percent, had memory decline.
While previous research has focused on the medial temporal lobe of the brain, which is strongly associated with memory, researchers looked at volume changes across a number of regions in the temporal and parietal lobes. The parietal lobe is primarily associated with the processing of sensory information and is involved in a number of cognitive and language processes.
The predictive accuracy of the classification model increased as the number of bra
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Radiological Society of North America