Navigation Links
MRI catches breast cancer early in at-risk survivors of childhood Hodgkin lymphoma

(TORONTO, Canada May 28, 2014) The largest clinical study to evaluate breast cancer screening of female survivors of childhood Hodgkin lymphoma (HL), who are at increased risk because they received chest radiation, shows that magnetic-resonance imaging (MRI) detected invasive breast tumours at very early stages, when cure rates are expected to be excellent.

The finding, published online today in the American Cancer Society Journal Cancer (doi: doi/10.1002/cncr.28747), underscores the need for at-risk childhood HL survivors and primary care physicians to be aware of established guidelines that recommend breast MRI screening from the age of 25 years or eight years following chest radiation (whichever is later), says principal investigator Dr. David Hodgson, a radiation oncologist at Princess Margaret Cancer Centre, University Health Network.

Dr. Hodgson, also an Associate Professor, Faculty of Medicine, University of Toronto, talks about the research:

"Female survivors of childhood HL who had chest radiation should speak with their family doctor about after-care assessment and breast cancer screening" says Dr. Hodgson.

"We estimate that 75% of women who are at high risk because of prior radiotherapy to the chest are not being screened. So my hope is that this new evidence will encourage these survivors to discuss early screening with their doctors.There is a provincial pediatric oncology aftercare system already in place to help them, organized by the Pediatric Oncology Group of Ontario (POGO)."

Dr. Hodgson's study team, in collaboration with colleagues at the Dana Farber Cancer Institute in Boston, performed 274 breast MRI screens on 96 women from 2005 to 2012. Ten breast cancers half of them invasive tumors were diagnosed in nine women during 363 person-years follow up. The median age of breast cancer diagnosis was 39 years (range 24 to 43 years), and the median latency period between HL diagnosis and age at breast cancer diagnoses was 21 years (range 12 to 27 years). "This illustrates the young age at which these cancers can occur. For some of these women, if they had been screened starting at age 40 or 50 like average risk women, it would have been too late."

Of the 10 detected breast tumours, five were visible on both MRI and mammogram; three were visible only on MRI; and two were detected on mammogram alone (but were non-invasive). The median size of invasive tumors size was 8mm (range 3-15mm) and none had spread to the lymph nodes. These results are substantially better than prior studies using only mammographic screening in these young patients, in which almost half of the cancers detected had cancer spread to lymph nodes. Dr. Hodgson points out that because MRI screening is so much more sensitive to small changes in the appearance of the breast tissue than mammography, up to a third of patients may be called back for further testing of suspicious findings, many of which are benign or not clinically significant and therefore require no treatment. "It's important to forewarn at-risk HL survivors because call backs definitely heighten anxiety."


Contact: Jane Finlayson
University Health Network

Related medicine news :

1. Health care safety net catches suburban poor
2. They’re Back: Web Cam Catches Sockeye Salmon Returning to Tongass Spawning Grounds
3. Seva Call Launches in KC to Get Great Catches on the Line for Missouri River Consumers and Businesses
4. Study identifies risk of chemotherapy related hospitalization for eary-stage breast cancer patients
5. Researchers identify a new suppressor of breast metastasis to the lung
6. Two new possible drug targets for triple negative breast cancer
7. SLU virologists harness adenovirus to kill breast cancer cells
8. Yale Cancer Center studies find lifestyle changes improve biomarkers for breast cancer recurrence and mortality
9. Signals found that recruit host animals cells, enabling breast cancer metastasis
10. Breastfeeding initiation and success is impacted by diabetes status of mother
11. Cognitive behavioral or relaxation training helps women reduce distress during breast cancer treatment
Post Your Comments:
Related Image:
MRI catches breast cancer early in at-risk survivors of childhood Hodgkin lymphoma
(Date:12/1/2015)... (PRWEB) , ... December 01, 2015 , ... Dr. Paul ... Vitenas Cosmetic Surgery, has been named by MedEsthetics magazine as the Best Single Physician ... the best among the many elite aesthetic physicians honored by the industry publication. ...
(Date:12/1/2015)... ... December 01, 2015 , ... CloudLIMS today ... Golden Bridge Business Awards under the New Products and Services category for its ... sample management software that helps labs organize data and track samples ...
(Date:12/1/2015)... ... December 01, 2015 , ... ... must mark the film for accurate interpretation by the radiologist. The marking utensils ... inventor from Sacramento, Calif., has found a way to alleviate this problem. , ...
(Date:12/1/2015)... ... , ... McLean, VA., December 1, 2015 - Octo Consulting ... agile development contract to support the National Geospatial-Intelligence Agency's (NGA) IT Services Directorate. ... infrastructure, as well as operations and sustainment support to the NGA’s Agile Web ...
(Date:12/1/2015)... ... 01, 2015 , ... PartnerTech , a leader in ... since 2008. Gary Bruce, President of PartnerTech North America, currently serves as Director ... amount of time in Sweden since joining PartnerTech based in Malmo, Sweden. He ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... , Dec. 1, 2015 As enforcement of ... Chain Security Act (DSCSA) approaches, InfiniTrak ... independent pharmacies comply with looming FDA regulations. ... is entering endorsement agreements with State Pharmacy Associations, ... administration organization (PSAO) to exclusively provide the InfiniTrak ...
(Date:12/1/2015)... DUBLIN , Dec. 01, 2015 /PRNewswire/ ... announced the addition of the "Spinal ... Growth, Trends, and Forecast 2015 - 2023" ... ) has announced the addition ... - Pipeline Assessment, Size, Growth, Trends, and ...
(Date:12/1/2015)... -- Royal Philips  (NYSE: PHG, AEX: ... software that produces high-contrast images for all anatomies in ... at the 2015 Radiological Society of North America ... first digital imaging solution providing grid-like contrast improvement and ... and supports "first-time-right imaging" by decreasing the need for ...
Breaking Medicine Technology: