Navigation Links
MRI can screen patients for Alzheimer's disease or frontotemporal lobar degeneration
Date:12/26/2012

PHILADELPHIA - When trying to determine the root cause of a person's dementia, using an MRI can effectively and non-invasively screen patients for Alzheimer's disease or Frontotemporal Lobar Degeneration (FTLD), according to a new study by researchers from the Perelman School of Medicine at the University of Pennsylvania. Using an MRI-based algorithm effectively differentiated cases 75 percent of the time, according to the study, published in the December 26th, 2012, issue of Neurology, the medical journal of the American Academy of Neurology. The non-invasive approach reported in this study can track disease progression over time more easily and cost-effectively than other tests, particularly in clinical trials testing new therapies.

Researchers used the MRIs to predict the ratio of two biomarkers for the diseases - the proteins total tau and beta-amyloid - in the cerebrospinal fluid. Cerebrospinal fluid analyses remain the most accurate method for predicting the disease cause, but requires a more invasive lumbar puncture. "Using this novel method, we obtain a single biologically meaningful value from analyzing MRI data in this manner and then we can derive a probabilistic estimate of the likelihood of Alzheimer's or FTLD," said the study's lead author, Corey McMillan, PhD, of the Perelman School of Medicine and Frontotemporal Degeneration Center at the University of Pennsylvania.

Using the MRI prediction method was 75 percent accurate at identifying the correct diagnosis in both patients with pre-confirmed disease diagnoses and those with biomarker levels confirmed by lumbar punctures, which shows comparable overlap between accuracy of the MRI and lumbar puncture methods. "For those remaining 25 percent of cases that are borderline, a lumbar puncture testing spinal fluid may provide a more accurate estimate of the pathological diagnosis."

Accurate tests to measure disease progression are very important in neurodegenera
'/>"/>

Contact: Kim Menard
kim.menard@uphs.upenn.edu
215-662-6183
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. IntegraGen launches ARISk test, a genetic screening tool for autism in high-risk children
2. Obese White Women Shying Away From Colon Cancer Screening
3. Lung Cancer Screening Might Pay Off, Analysis Shows
4. U.S. Panel Rejects Ovarian Cancer Screening
5. AstraZeneca and DNDi to collaborate on drug screening for neglected tropical diseases
6. Role of Screening, Monitoring in Early Kidney Disease Unclear
7. Screening programs detect cases of undiagnosed rheumatic heart disease in low-resource countries
8. Additional blood pressure screening may reduce incidence of CVD events and death by up to 3 percent
9. Routine Kidney Disease Screening Not Worthwhile, Experts Say
10. Risk factors may inform breast cancer screening
11. Research examines when benefits of screening mammography outweigh the harms for women in their 40s
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... , ... June 30, 2015 , ... According to a ... a $3.1 million grant to study how sensory stimuli can be used to “decrease ... on improving care for children with autism, will compare patient experience in a “typical ...
(Date:6/30/2015)... (PRWEB) , ... June 30, 2015 , ... ... buying eyeglasses online , finally its here, http://www.express-glasses.com is ... shipping rates, for many location, ask about shipping with DHL Express when calling ...
(Date:6/30/2015)... , ... June 30, 2015 , ... Rocky Mountain Oils, ... restructured its management team and added a new CEO, Mr. Darold Francis. The changes ... selection of premium essential oils that customers have come to know and respect for ...
(Date:6/30/2015)... ... 2015 , ... MJH Associates today welcomed Jim ... & Analytics , a consultative healthcare market research practice that is part of ... offers quantitative and qualitative, custom and multi-client primary market research services to support ...
(Date:6/30/2015)... ... June 30, 2015 , ... An opinion piece published ... transfer procedures had over breast implants when reconstructing breasts after a mastectomy. The ... and feel natural,” have increased sensation, and are less likely than implant reconstructions ...
Breaking Medicine News(10 mins):Health News:New Study Aims to Determine if Sensory Stimuli can Ease Dental Anxiety in Children, Notes Medical Center Dental Care 2Health News:New Study Aims to Determine if Sensory Stimuli can Ease Dental Anxiety in Children, Notes Medical Center Dental Care 3Health News:Eyeglasses Online - Express Glasses Announcing New International Shipping Using DHL 2Health News:Rocky Mountain Oils Adds New CEO, Announces Relocation of Operations to Orem, Utah 2Health News:HRA Healthcare Research & Analytics Welcomes 'Creative Problem Solver' as New Executive Vice President 2Health News:HRA Healthcare Research & Analytics Welcomes 'Creative Problem Solver' as New Executive Vice President 3Health News:Recent Article Advocating for Breast Reconstruction with Fat Transfers Successfully Outlines the Advantages of Transfer Procedures, Notes Beverly Hills Physicians 2Health News:Recent Article Advocating for Breast Reconstruction with Fat Transfers Successfully Outlines the Advantages of Transfer Procedures, Notes Beverly Hills Physicians 3
... has invited best-selling author and noted physician Abraham Verghese to ... and Human Values at 7:30 p.m., Monday, Oct. 24 at ... Indian-American immigrant to the United States, Dr. Verghese,s varied professional ... India studies program at UH," said Lois Zamora, chair of ...
... Phase III trial of RTS,S*, published online today in the ... malaria vaccine candidate to provide young African children with significant ... and tolerability profile. The results were announced today at the ... in Seattle, Washington. Half the world,s population is at ...
... HealthDay Reporter , MONDAY, Oct. 17 (HealthDay ... conventional Pap tests as a cervical cancer screening tool ... The U.S. Preventive Services Task Force ... researchers are now seeking to fine-tune these guidelines. The ...
... (IAN Project) launches a national survey to study the ... (ASD). Bullying, a pervasive problem among youth, has attracted ... lasting, and sometimes tragic, effects on children and teenagers ... be especially vulnerable targets due to their social deficits ...
... (HealthDay News) -- Experts at the American Academy of Pediatrics ... for sudden infant death syndrome (SIDS). Those are two ... SIDS guidelines. Since 1992, when the AAP recommended that ... SIDS has declined sharply in the United States, according to ...
... Cypress, CA, October 18, 2011 Technology has radically ... this more evident than in the field of gynecologic ... teaching minimally invasive treatment for women,s health problems, will ... tools among the hundreds of postgraduate courses and practice ...
Cached Medicine News:Health News:Dr. Abraham Verghese to give John P. McGovern Lecture on Oct. 24 2Health News:Malaria vaccine candidate, RTS,S reduces the risk of malaria by half in African children 2Health News:Malaria vaccine candidate, RTS,S reduces the risk of malaria by half in African children 3Health News:Pap Test Still Best for Cervical Cancer Screening, Experts Say 2Health News:Pap Test Still Best for Cervical Cancer Screening, Experts Say 3Health News:National survey will measure how bullying impacts children with autism 2Health News:Breast-Feeding, Vaccinations Lower SIDS Risk, Experts Say 2Health News:Innovations in minimally invasive surgery and education are highlights of 40th AAGL Global Congress 2Health News:Innovations in minimally invasive surgery and education are highlights of 40th AAGL Global Congress 3Health News:Innovations in minimally invasive surgery and education are highlights of 40th AAGL Global Congress 4
(Date:6/30/2015)... BERKELEY, Calif. and COPENHAGEN, ... CMC Biologics, Inc. , a global leader in clinical ... proteins, announced today that, as part of its global ... of its North American manufacturing facility in ... single-use Bioreactor 6Pack™ facility.  The Bioreactor 6Pack™ configuration consists ...
(Date:6/30/2015)... 2015 Legal-Bay LLC, the Lawsuit Settlement Funding ... the multidistrict litigation (MDL) over the Zimmer NexGen Knee ... th , 2015. There are currently more than a ... before a federal judge in Illinois ... will begin in October of this year. Zimmer Inc. ...
(Date:6/29/2015)... -- Mordor Intelligence presents their Global Pharmaceutical ... Glass, Paper, Metal) - ByType of Packaging (Ampules, Blister Packs, ... Sachets) - By Geographical Region ( North America ... , Latin America , ... - discussing Industry Value Chain Analysis, Porter,s 5 Force Analysis, ...
Breaking Medicine Technology:CMC Biologics Expands GMP Manufacturing Capacity in the United States 2CMC Biologics Expands GMP Manufacturing Capacity in the United States 3Legal-Bay Lawsuit Settlement Funding Reports Zimmer NexGen Knee Bellwether Trial to Begin October 13th, 2015 2Legal-Bay Lawsuit Settlement Funding Reports Zimmer NexGen Knee Bellwether Trial to Begin October 13th, 2015 3Global Pharmaceutical Packaging Market - North America and Europe Expected to Lead Followed by the Asia Pacific Market 2Global Pharmaceutical Packaging Market - North America and Europe Expected to Lead Followed by the Asia Pacific Market 3
... InfraReDx, Inc. , a medical device ... announced the completion of a $21 million equity ... as well as existing investors, including Sanderling Ventures. ... support the full commercial launch of the LipiScan™ ...
... NEW YORK, Oct. 12 Reportlinker.com ... report is available in its catalogue: ... Sales Force Effectiveness in Pharmaceuticals ... Adoption of New Sales Models and ...
Cached Medicine Technology:InfraReDx Completes $21 Million Equity Financing 2InfraReDx Completes $21 Million Equity Financing 3Reportlinker Adds Sales Force Effectiveness in Pharmaceuticals - Cost Pressures Increase Pharmaceutical Companies' Adoption of New Sales Models and Technologies 2Reportlinker Adds Sales Force Effectiveness in Pharmaceuticals - Cost Pressures Increase Pharmaceutical Companies' Adoption of New Sales Models and Technologies 3Reportlinker Adds Sales Force Effectiveness in Pharmaceuticals - Cost Pressures Increase Pharmaceutical Companies' Adoption of New Sales Models and Technologies 4Reportlinker Adds Sales Force Effectiveness in Pharmaceuticals - Cost Pressures Increase Pharmaceutical Companies' Adoption of New Sales Models and Technologies 5Reportlinker Adds Sales Force Effectiveness in Pharmaceuticals - Cost Pressures Increase Pharmaceutical Companies' Adoption of New Sales Models and Technologies 6Reportlinker Adds Sales Force Effectiveness in Pharmaceuticals - Cost Pressures Increase Pharmaceutical Companies' Adoption of New Sales Models and Technologies 7Reportlinker Adds Sales Force Effectiveness in Pharmaceuticals - Cost Pressures Increase Pharmaceutical Companies' Adoption of New Sales Models and Technologies 8
... 3.5v Halogen HPX ... a lithium-ion handle and ... output than conventional scopes ... output level which greatly ...
Video Equipment...
Sandown chair, with hydraulic lift, sliding headrest and armrests with glides. Black vinyl....
Heine Beta 200 Streak Retinoscope 3.5v...
Medicine Products: