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MRI Simulation of Blood Flow Helps Plan Child's Heart Surgery
Date:8/11/2009

ation of the patient's anatomy. After analyzing the three-dimensional reconstruction of the failing cardiovascular geometry, the team considered three surgical options.

The research team then performed computational fluid dynamics simulations on all three options to investigate for each how well blood would flow to the lungs and the amount of energy required to drive blood through each connection design. These measures of clinical performance allowed the cardiologists and surgeons to conduct a risk/benefit analysis, which also included factors such as difficulty of completion and potential complications.

Of the three choices, Spray favored the option that showed a slightly higher energy cost but exhibited the best performance with regards to hepatic factor distribution to the left and right lungs. Five months after the surgery, Mayer showed a dramatic improvement in her overall clinical condition and oxygen saturation levels, which increased from 72 to 94 percent. Mayer is breathing easier and is now able to play actively like other children, according to her cardiologist, Donald Putman, M.D., of Staten Island, N.Y.

"The ability to perform this work is a team effort," Fogel added. "State-of-the-art three-dimensional cardiac MRI married to modern biomedical engineering and applied anatomy and physiology enabled this approach. With the advanced pediatric cardiothoracic surgery we have here at The Children's Hospital of Philadelphia, patients can benefit from this new method."

Additional authors on the paper include Shiva Sharma from Pediatric Cardiology Services, Kirk Kanter from the Division of Cardiothoracic Surgery at Emory University, and Fotis Sotiropoulos from the Department of Civil Engineering at the University of Minnesota.

This work was funded by grant number HL67622 from the National Heart, Lung and Blood Institute (NHLBI) of the National Institutes of Health (NIH
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SOURCE The Children's Hospital of Philadelphia
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