Navigation Links
MRI: A window to genetic properties of brain tumors
Date:3/24/2008

Doctors diagnose and prescribe treatment for brain tumors by studying, under a microscope, tumor tissue and cell samples obtained through invasive biopsy or surgery. Now, researchers at UCSD School of Medicine have shown that Magnetic Resonance Imaging (MRI) technology has the potential to non-invasively characterize tumors and determine which of them may be responsive to specific forms of treatment, based on their specific molecular properties. The study will be published on line by the Proceedings of the National Academy of Science (PNAS) the week of March 24.

This approach reveals that, using existing imaging techniques, we can identify the molecular properties of tumors, said Michael Kuo, M.D., assistant professor of interventional radiology at UCSD School of Medicine. Kuo and colleagues analyzed more than 2,000 genes that had previously been shown to have altered expression in Glioblastoma multiforme (GBM) tumors. They then mapped the correlations between gene expression and MRI features.

The researchers also identified characteristic imaging features associated with overall survival of patients with GBM, the most common and lethal type of primary brain tumor.

The researchers discovered five distinct MRI features that were significantly linked with particular gene expression patterns. For example, one specific characteristic seen in some images is associated with proliferation of the tumor, and another with growth and formation of new blood vessels within the tumorboth of which are susceptible to treatment with specific drugs.

These physiological changes seen in the images are caused by genetic programs, or patterns of gene activation within the tumor cells. Some of these programs are tightly associated with drug targets, so when they are detected, they could indicate which patients would respond to a particular anti-cancer therapy, according to the researchers.

For the first time, we have shown that the activity of specific molecular programs in these tumors can be determined based on MRI scans alone, said Kuo. We were also able to link the MRI with a group of genes that appear to be involved in tumor cell invasiona phenotype associated with a reduced rate of patient survival.

Laboratory work that relies on tissue samples is routinely used to diagnose and guide treatment for GBM. However, the biological activity shown may depend on the portion of the tumor from which the tissue sample is obtained. The researchers have shown that MRI could be used to identify differences in gene expression programs within the same tumor.

Gene expression results in the production of proteins, which largely determine a tumors characteristics and behavior. This non-invasive MRI method could, for example, detect which part of a tumor expresses genes related to blood vessel formation and growth or tumor cell invasion, said Kuo. Understanding the genetic activity could prove to be a very strong predictor of survival in patients, and help explain why some patients have better outcomes than others.

Kuo also led a study, published in Nature Biotechnology in May 2007, correlating CT images of cancerous tissue with gene expression patterns in liver tumors. In the new study, we were able to take a different imaging technology, MRI, and apply it to a totally different tumor type, he said, noting that the studies open up promising new avenues for non-invasive diagnoses and classification of cancer.


'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Related medicine news :

1. Windows Live $500,000 Donation Commemorates Operation Smiles 25th Anniversary
2. Eyes a Window to Hearing Loss?
3. Transparent Fish Gives New Window on Disease
4. Camera in a pill offers cheaper, easier window on your insides
5. Pharmacists believe drive-through windows contribute to delays, errors
6. New Web Site Opens Window on Charges, Payments, Quality of Care at Michigan Hospitals
7. OHSU Cancer Institute research discovery opens new window to understanding chronic myeloid leukemia
8. A pain-free window into painful neuropathies
9. Poor Senior Vision Often a Window on Disease
10. Genetic Engineering & Biotechnology News reports on clinical trials in developing countries
11. Genetic Medicine Making Inroads Against Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... ... ... the Stars Lead Home”: a poignant story of loss, determination, and perseverance. “When the ... reader who lives in the Pacific Northwest with her husband, daughter, two dogs, and ... couldn’t be more grateful. , Twelve-year old Tizzy could not believe how quickly things ...
(Date:5/26/2017)... ... May 26, 2017 , ... ... recipient of proceeds from its 14th Annual Clays for Kids fundraiser, to be ... 30, Bennett, Colorado. , As part of BluSky’s partnership with The Adoption ...
(Date:5/26/2017)... ... , ... “Cactus Jack: Against All Odds”: the story of Coach Cactus Jack ... All Odds” is the creation of published author, Walter Hubbard, a retired wildlife and ... third child Jane. Walter. Walter and Jane have three adult children and a ...
(Date:5/24/2017)... N.J. (PRWEB) , ... May 24, 2017 , ... ... Clara Maass Medical Center CEO Mary Ellen, hospital employees, and town officials to ... Belleville. , The facility was developed by Rendina as part of its ongoing ...
(Date:5/24/2017)... New York (PRWEB) , ... May 24, 2017 , ... ... vascular surgery in New York City. He is known for his distinguished ... specialization in vascular surgery, Dr. Benvenisty holds sub-specialty training in treating renovascular disease and ...
Breaking Medicine News(10 mins):
(Date:5/6/2017)... N.Y. , May 5, 2017  Hill-Rom Holdings, ... will add approximately 100,000 square feet to its Welch ... September 2016 its commitment to bring more than 100 ... , where Welch Allyn has maintained a significant presence ... help accommodate these new positions, a large portion of ...
(Date:5/4/2017)... CAESAREA, Israel , May 4, 2017  DarioHealth ... with mobile health and big data solutions, today announced ... an A&D Company, and STI Technologies Limited to lower ... effective immediately. Through STI,s innoviCares card, which is available ... , DarioHealth customers will be eligible for additional ...
(Date:5/3/2017)... 3, 2017  Getinge, a leading global provider ... enhancement and cost efficiency within healthcare and life ... contemporary practice demonstrating that intra-aortic balloon counterpulsation (IABC) ... ill patients. The single-center, retrospective, observational study showed ... MEGA ® 50cc intra-aortic balloon (IAB) in ...
Breaking Medicine Technology: