Navigation Links
MRC scientists advance understanding of cell death
Date:8/13/2009

Medical Research Council (MRC) scientists have made an important advance in understanding the biological processes involved when cells are prompted to die. The work may help scientists to eventually develop new treatments for the many common diseases and conditions which occur when cell death goes wrong.

The research, published in leading journal Molecular Cell [1] today (Friday 14 August 2009) was carried out by a team of scientists, at the MRC Toxicology Unit at the University of Leicester and a subsequent patent application has been filed by MRC Technology, the commercial arm of the MRC.

Cells in the human body are continually dying and most of these cells kill themselves by a form of cell death, commonly referred to as apoptosis. In a healthy body, the number of cells stays constant. Millions of new cells are produced every second, and millions of others are lost or kill themselves. Failure of the normal apoptosis process plays a role in different diseases including cancer, certain neurodegenerative disorders such as Parkinson's and immune diseases, such as autoimmune lymphoproliferative syndrome (ALPS).

One of the study's authors, Dr Marion MacFarlane, MRC Toxicology Unit, explained: "This new research takes us a step closer to understanding how the DISC triggers cells to die. The challenge now is to try and use this fundamental knowledge to help work towards finding better treatments for conditions which occur when DISC-mediated cell death goes wrong."

Previous research has shown that a complex called the 'DISC', which is made up of different proteins and is formed following activation of molecules called 'Death Receptors', can trigger apoptosis by 'switching on' key players in the cell death process. However, previous research has found that the DISC can also activate cell survival, thus raising the question as to how paradoxically the 'DISC' can trigger these opposing cellular outcomes?

Now, scientist
'/>"/>

Contact: Nicola Osmond-Evans
press.office@headoffice.mrc.ac.uk
020-767-05138
University of Leicester
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... HealthDay Reporter WEDNESDAY, Dec. ... chronic illnesses can receive effective, less expensive care from a ... to a team of dedicated health care professionals, a new ... ill and need either hospitalization or a trip to the ... home clinic at the University of Texas in Houston versus ...
(Date:12/25/2014)... Dennis Thompson HealthDay Reporter ... closing in on a "fountain of youth" drug that can ... older adults, a new study suggests. Seniors received a ... that targets a genetic signaling pathway linked to aging and ... The experimental medication, a version of the drug ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 Plugin creators ... ProFire 5k. A fully customizable business presentation tool made ... “Adding the ProFire 5k business tool, users can now ... Austin, CEO of Pixel Film Studios. “ProFire 5k gives ... style to add professionalism to a presentation” , Pixel ...
(Date:12/24/2014)... AlignLife of Wauwatosa loves helping those in the ... holiday season, AlignLife looks forward to their annual toy drive. ... Mahalko-Leonhardt, owner of AlignLife. "It brings our patients as well ... able to give kids toys for Christmas who would be ... of our patients." , The 70 toys were donated to ...
(Date:12/24/2014)... Recently, iFitDress.com, a famous dress manufacturer and retailer, ... $150 . All these items are brand new; they are ... been updated with the new range of high quality prom ... All iFitDress.com’s designs are made according to the latest trends. ... Every outfit from the company is handpicked by skilled tailors. ...
Breaking Medicine News(10 mins):Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3Health News:Announcing a new ProFire 5k plugin from Pixel Film Studios for Final Cut Pro X Professionals 2Health News:AlignLife of Wauwatosa Brings Joy to Less Fortunate Families 2Health News:Many Prom Dresses under 150 from Well-known Dress Manufacturer iFitDress.com 2
... the artery-opening devices , , FRIDAY, May 9 (HealthDay News) ... tiny tools that have extended the lives of millions ... their arteries. , The wire metal mesh tubes, when ... artery and ensure a constant supply of blood to ...
... Week with Signing Bonuses, Raises, SAGINAW, Mich., May ... Saginaw voted overwhelmingly last,night to accept their first labor ... year wage increases of 4 percent., (Logo: ... Week I have had in years. The money is,important, ...
... May 9 Brookdale Senior,Living Inc. (NYSE: BKD ... the Company at the Bank of America 2008 Health ... Mandalay Bay in Las Vegas,Nevada at 4:40 p.m. PDT ... being webcast live and can be accessed through the,Bank ...
... May 9 Tim Booth, a 20-year health,care ... CEO of PrePak Systems,Inc., a turnkey pharmaceutical packaging ... last week by the company,s parent, PrePak,Holdings, which ... and,expansion with financial support from its largest shareholders, ...
... May 9 Almost Family, Inc.,(Nasdaq: AFAM ... nursing,services, today announced that the underwriter of the ... and purchased 262,500,additional shares of common stock at ... the over-allotment, the Company sold 2,512,500 shares,in the ...
... painful periods, glaucoma, depression and many other diseases, ... -- A new class of drugs called vaptans ... of conditions including painful periods, brain hemorrhage, psychotic ... short for vasopressin-receptor antagonists, work by targeting the ...
Cached Medicine News:Health News:Drug-Coated Stents Still Spark Debate 2Health News:Drug-Coated Stents Still Spark Debate 3Health News:Saginaw Nurses Approve First Contract 2Health News:Booth Joins PrePak Systems for Growth, Expansion 2Health News:Almost Family, Inc. Announces Exercise of Over-Allotment Option 2Health News:New Class of Drugs Might Treat Many Conditions 2
(Date:12/24/2014)... -- In response to urgent requests from the Deputy Minister of ... , Direct Relief delivered two 10-bed medical tents to ... local health workers who contract Ebola while fighting the outbreak. ... was constructed for foreign health care workers who may contract ... Sierra Leonean health workers. With Sierra ...
(Date:12/22/2014)... , Dec. 22, 2014  CytoSorbents Corporation (OTCQB:CTSOD), ... CytoSorb® blood purification technology to help fight deadly ... 28 countries worldwide, today announced the appointment of ... FACS, as its Senior Vice President of Clinical ... Dr. Di Russo is an accomplished ...
(Date:12/22/2014)... and Markets ( http://www.researchandmarkets.com/research/h3xm6q/us ) has announced ... Market" report to their offering. ... focuses on the developments in the self-monitoring blood glucose ... Reimbursement analysis and the effects of competitive bidding have ... SMBG meters have been performed, based on the various ...
Breaking Medicine Technology:First Ebola Treatment Unit for Local Health Workers Arrives in Sierra Leone 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5US Self-monitoring Blood Glucose Market 2
... WASHINGTON , July 28 Today FRC Action joined 19 pro-life groups ... requesting that Ella, a drug under consideration for FDA approval that can cause abortions but ... , , ... Vice President , made the following comments: , ...
... July 28 Delcath Systems, Inc. (Nasdaq: DCTH ) announced today ... Management Access Conference in New York, NY on Tuesday, August ... Chief Financial Officer, will review the company,s business strategy and recent corporate developments. ... Attendance at this conference is ...
Cached Medicine Technology:FRC Action and Pro-Life Coalition Urge the FDA to Reject New Abortion-Causing Drug 2Delcath to Present at the 2010 Wedbush Securities Life Sciences Best Ideas Management Access Conference 2Delcath to Present at the 2010 Wedbush Securities Life Sciences Best Ideas Management Access Conference 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: