Navigation Links
MIT's PANTHER sensor quickly detects pathogens
Date:3/4/2008

CAMBRIDGE, Mass.--Researchers at MIT Lincoln Laboratory have developed a powerful sensor that can detect airborne pathogens such as anthrax and smallpox in less than three minutes.

The new device, called PANTHER (for PAthogen Notification for THreatening Environmental Releases), represents a significant advance over any other sensor, said James Harper of Lincoln Lab's Biosensor and Molecular Technologies Group. Current sensors take at least 20 minutes to detect harmful bacteria or viruses in the air, but the PANTHER sensors can do detection and identification in less than three minutes.

The technology has been licensed to Innovative Biosensors Inc. (IBI) of Rockville, Md. In January, IBI began selling a product, BioFlash, that uses the PANTHER technology.

There is a real need to detect a pathogen in less than three minutes, so you have time to take action before it is too late, said Harper, the lead scientist developing the sensor.

The PANTHER sensor uses a cell-based sensor technology known as CANARY (after the birds sent into mines to detect dangerous gases), and can pick up a positive reading with only a few dozen particles per liter of air.

The device could be used in buildings, subways and other public areas, and can currently detect 24 pathogens, including anthrax, plague, smallpox, tularemia and E. coli.

There's really nothing out there that compares with this, said Todd Rider of Lincoln Lab's Biosensor and Molecular Technologies Group, who invented the CANARY sensor technology.

Rider started developing CANARY in 1997 when he realized that there were no sensors available that could rapidly detect pathogens. His idea was to take advantage of nature's own defense system-specifically the B cells that target pathogens in the human body. B cells in the body are very fast and very sensitive, Rider said.

The CANARY concept uses an array of B cells, each specific to a particular bacterium or virus. The cells are engineered to emit photons of light when they detect their target pathogen. The device then displays a list of any pathogens found.

CANARY is the only sensor that makes use of immune cells. Other available sensors are based on immunoassays or PCR (polymerase chain reaction), which take much longer and/or are not as sensitive as CANARY.

Rider and colleagues first reported the success of CANARY (which stands for Cellular Analysis and Notification of Antigen Risks and Yields) in the journal Science in 2003. Since then, they have been working to incorporate the technology into a portable device that could be used in a variety of settings where environmental threats might exist.

The new device, PANTHER, takes the CANARY technology and combines it with an air sampler that brings pathogens into contact with the detector cells. The prototype sensor is about a cubic foot and weighs 37 pounds and is well suited to building-protection applications. With minor modifications it could also enhance biological detection capabilities for emergency responders.

CANARY has been tested in rural and coastal environments as well as urban ones. It could eventually be used on farms or in food-processing plants to test for contamination by E. coli, salmonella or other food-borne pathogens.

Another potential application is in medical diagnostics, where the technology could be used to test patient samples, giving rapid results without having to send samples to a laboratory.

Instead of going to the doctor's office and waiting a few days for your test results, with CANARY you could get the results in just a minute or so, said Rider.


'/>"/>

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
Source:Eurekalert

Related medicine news :

1. Gates Foundation Commits $280 Million for Research to Fight Global TB Epidemic
2. Cephalon Submits New Drug Application for TREANDA for the Treatment of Chronic Lymphocytic Leukemia
3. New Study Shows Arthritis Significantly Limits Millions of Americans Ability to Work
4. Global Med Technologies(R), Inc. Submits ElDorado Donor(TM) to FDA
5. MacArthur commits $11 million to further UCSF work in maternal safety
6. Banco Popular Commits To Make A Difference Day 2007
7. Johnson & Johnson Pharmaceutical Research & Development Submits New Drug Application for Paliperidone Palmitate
8. Michael J. Fox Foundation Commits Up to $2 Million for PD Drug Development Under Target Validation 2008
9. Certain Cholesterol Drugs Show Their Limits
10. Gates Foundation Commits to Expansion of HIV Prevention in China
11. SGX Pharmaceuticals Submits Investigational New Drug Application for SGX523, a Highly Potent, Selective, Orally Bioavailable cMET Inhibitor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... ... 2017 , ... The VA Maryland Health Care System and ... project focused on multiple sclerosis (MS). Led by Christopher M. Jewell, PhD, an ... disease without compromising normal immune function that often occurs during autoimmune diseases. Ultimately ...
(Date:1/18/2017)... Cranbury, NJ (PRWEB) , ... ... ... Times®, the specialty pharmacy industry‚Äôs leading journal and most-read publication among specialty ... Vanderbilt University Medical Center through its Strategic Alliance Partnership (SAP) program, announced ...
(Date:1/18/2017)... ... January 18, 2017 , ... A Palm Beach doctor ... Smile Train, an international charity that provides free surgery to poor children suffering from ... in the past I have run to support the efforts of the American Heart ...
(Date:1/18/2017)... , ... January 18, 2017 , ... The Portee Insurance ... families and business owners in central Maryland and the DC region, is inaugurating a ... kills 787,000 people nationally every year, making it the #1 killer in America. However, ...
(Date:1/18/2017)... ... , ... At Hallmark Nameplate, their commitment to quality is what sets them ... 13485. This certification is another way they are making constant strides to provide all ... need. , The ISO 13485 Certification is a major accomplishment for Hallmark Nameplate and ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... -- Aprima Medical Software, a leading provider of innovative ... revenue cycle management (RCM) solutions for medical practices, ... Healthcare Data Solutions (HDS) of Coral Cables, FL. ... full support for HDS,s customers, which include approximately ... states. Financial terms were not disclosed. ...
(Date:1/18/2017)... JOSE, Calif. , Jan. 18, 2017  Adaptive Sound ... announced today a new partnership with Hyatt Place Nashville/Downtown ... by providing ASTI LectroFan sleep therapy machines in over ... one of the most important parts of having a ... , general manager of Hyatt Place Nashville/Downtown. "We,re pleased ...
(Date:1/18/2017)... PUNE, India , January 18, 2017 According to ... Type and by Application: Global Opportunity Analysis and Industry Forecast, 2014 - 2022," ... expected to reach $1,127 million by 2022, growing at a CAGR of 8.26% ... share, in terms of revenue. Continue Reading ... ...
Breaking Medicine Technology: