Navigation Links
MIT's PANTHER sensor quickly detects pathogens
Date:3/4/2008

CAMBRIDGE, Mass.--Researchers at MIT Lincoln Laboratory have developed a powerful sensor that can detect airborne pathogens such as anthrax and smallpox in less than three minutes.

The new device, called PANTHER (for PAthogen Notification for THreatening Environmental Releases), represents a significant advance over any other sensor, said James Harper of Lincoln Lab's Biosensor and Molecular Technologies Group. Current sensors take at least 20 minutes to detect harmful bacteria or viruses in the air, but the PANTHER sensors can do detection and identification in less than three minutes.

The technology has been licensed to Innovative Biosensors Inc. (IBI) of Rockville, Md. In January, IBI began selling a product, BioFlash, that uses the PANTHER technology.

There is a real need to detect a pathogen in less than three minutes, so you have time to take action before it is too late, said Harper, the lead scientist developing the sensor.

The PANTHER sensor uses a cell-based sensor technology known as CANARY (after the birds sent into mines to detect dangerous gases), and can pick up a positive reading with only a few dozen particles per liter of air.

The device could be used in buildings, subways and other public areas, and can currently detect 24 pathogens, including anthrax, plague, smallpox, tularemia and E. coli.

There's really nothing out there that compares with this, said Todd Rider of Lincoln Lab's Biosensor and Molecular Technologies Group, who invented the CANARY sensor technology.

Rider started developing CANARY in 1997 when he realized that there were no sensors available that could rapidly detect pathogens. His idea was to take advantage of nature's own defense system-specifically the B cells that target pathogens in the human body. B cells in the body are very fast and very sensitive, Rider said.

The CANARY concept uses an array of B cells, each specific to a particular bacterium or virus. The cells are engineered to emit photons of light when they detect their target pathogen. The device then displays a list of any pathogens found.

CANARY is the only sensor that makes use of immune cells. Other available sensors are based on immunoassays or PCR (polymerase chain reaction), which take much longer and/or are not as sensitive as CANARY.

Rider and colleagues first reported the success of CANARY (which stands for Cellular Analysis and Notification of Antigen Risks and Yields) in the journal Science in 2003. Since then, they have been working to incorporate the technology into a portable device that could be used in a variety of settings where environmental threats might exist.

The new device, PANTHER, takes the CANARY technology and combines it with an air sampler that brings pathogens into contact with the detector cells. The prototype sensor is about a cubic foot and weighs 37 pounds and is well suited to building-protection applications. With minor modifications it could also enhance biological detection capabilities for emergency responders.

CANARY has been tested in rural and coastal environments as well as urban ones. It could eventually be used on farms or in food-processing plants to test for contamination by E. coli, salmonella or other food-borne pathogens.

Another potential application is in medical diagnostics, where the technology could be used to test patient samples, giving rapid results without having to send samples to a laboratory.

Instead of going to the doctor's office and waiting a few days for your test results, with CANARY you could get the results in just a minute or so, said Rider.


'/>"/>

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
Source:Eurekalert

Related medicine news :

1. Gates Foundation Commits $280 Million for Research to Fight Global TB Epidemic
2. Cephalon Submits New Drug Application for TREANDA for the Treatment of Chronic Lymphocytic Leukemia
3. New Study Shows Arthritis Significantly Limits Millions of Americans Ability to Work
4. Global Med Technologies(R), Inc. Submits ElDorado Donor(TM) to FDA
5. MacArthur commits $11 million to further UCSF work in maternal safety
6. Banco Popular Commits To Make A Difference Day 2007
7. Johnson & Johnson Pharmaceutical Research & Development Submits New Drug Application for Paliperidone Palmitate
8. Michael J. Fox Foundation Commits Up to $2 Million for PD Drug Development Under Target Validation 2008
9. Certain Cholesterol Drugs Show Their Limits
10. Gates Foundation Commits to Expansion of HIV Prevention in China
11. SGX Pharmaceuticals Submits Investigational New Drug Application for SGX523, a Highly Potent, Selective, Orally Bioavailable cMET Inhibitor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Lake Orion, Clarkston, Michigan (PRWEB) , ... June ... ... direction with respect to fertility once they have been diagnosed with endometriosis. These ... tolerable intercourse but they also require a comprehensive approach that can help for ...
(Date:6/25/2016)... TX (PRWEB) , ... June 25, 2016 , ... ... the United States, named Dr. Sesan Ogunleye, as the Medical Director of its new ... the facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, ...
(Date:6/24/2016)... ... , ... A recent article published June 14 on E Online ... on to state that individuals are now more comfortable seeking to undergo not only ... calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Global law ... magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this recognition are ... , Seven Greenberg Traurig Shareholders received special honors as members of this year’s Legal ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Clinical Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The ... published in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... Bracket , a leading clinical trial technology ... outcomes platform, Bracket eCOA (SM) 6.0, at the 52 ... 30, 2016 in Philadelphia , Pennsylvania.  A ... product of its kind to fully integrate with RTSM, will ... 6.0 is a flexible platform for electronic clinical outcomes assessments ...
(Date:6/23/2016)... -- Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in ... . ... ... ... Astellas is ...
Breaking Medicine Technology: