Navigation Links
MIT study suggests caution on new anti-obesity drug in kids
Date:5/7/2008

Anti-obesity drugs that work by blocking brain molecules similar to those in marijuana could also interfere with neural development in young children, according to a new study from MITs Picower Institute for Learning and Memory.

Marijuana is known to be an appetite stimulant, and a new class of anti-obesity drugssuch as rimonabant (trade name Acomplia) developed by Sanofi-Aventis and awaiting approval for use in the United Stateswork by blocking brain receptors that bind to marijuana and other cannabinoids.

Marijuana, derived from the plant Cannabis sativa, contains special active compounds that are referred to collectively as cannabinoids. But other cannabinoids (endocannabinoids) are generated naturally inside the body.

The MIT study, which was done in mice, found that blocking cannabinoid receptors could also suppress the adaptive rewiring of the brain necessary for neural development in children. The work is reported in the May 8 issue of Neuron.

Our finding of a profound disruption of cortical plasticity in juvenile mice suggests caution is advised in the use of such compounds in children, wrote lead author Mark F. Bear, director of the Picower Institute and Picower Professor of Neuroscience.

The researchers investigated plasticitythe brains ability to change in response to experienceby temporarily depriving newborn mice of vision in one eye soon after birth. This well-known experiment induces a long-lasting loss of synapses that causes blindness in the covered eye, while synapses shift to the uncovered eye. How and where this synaptic shift occurs in the primary visual cortex has remained controversial.

Understanding the mechanism behind this phenomenon is key because the same brain mechanisms are used for normal development and may go awry in conditions that cause developmental delays in humans, and may reappear in old age and contribute to synaptic loss during Alzheimer's disease, Bear said.


'/>"/>
Contact: Teresa Herbert
therbert@mit.edu
617-258-5403
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Preliminary Results from Phase 2 Genzyme Study Highlight Potential of Novel Oral Compound for Gaucher Disease
2. Study in mice suggests molecules in plants have beneficial effect on Alzheimers disease
3. Women and heart attack: Study finds failure to recognize symptoms, failure to treat appropriately
4. Weill Cornell receives funding to study creation of new elder abuse center
5. Pilot study reinforces use of portable anteroom HEPA filtration
6. Warning: New Skin Cancer Study Finds Outdoor Workers are Less Likely to Get Screened for Skin Cancer
7. Study shows physician judgement important in reducing RSV-related hospitalizations
8. Study Suggests Stronger Tobacco Control Policies in States With High Smoking Rates Would be Effective in Reducing Smoking and Saving Thousands of Lives
9. Facet Solutions, Inc. Completes Combination Facet Joint and Disc Replacement Study
10. SDSU Study Reveals Eating at Friends and Familys Puts Kids at Higher Risk for Obesity
11. Study shows gene variations may predict risk of breast cancer in women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... (PRWEB) May 22, 2015 Memorial Day weekend ... Amica Insurance is offering some tips to help promote ... Council, there will be 383 traffic fatalities this Memorial Day ... the National Highway Traffic Safety Association: , ... the vehicle is wearing a seatbelt, whether they’re driving or ...
(Date:5/22/2015)... (PRWEB) May 22, 2015 Power Systems is ... for the 2015 race season. Drobeck is in his second ... as a firefighter with the Missoula Fire Department in Missoula, ... a Pro in 2014. During his career, he has had ... Pro, Drobeck recorded top 10 finishes in all seven of ...
(Date:5/22/2015)... (PRWEB) May 22, 2015 ... Health IT solutions, announced today that Bill Lane, ... is the developer of BlueEHS,a first of its ... offers a customizable Electronic Health Records (EHR) with ... interfaces, a telemedicine-enabled comprehensive patient portal, and more. ...
(Date:5/22/2015)... The dentist in West ... they are now offering complimentary consultations to patients ... At consultations, patients can discuss their candidacy for ... treatments can achieve and whether alternative options are ... appointment. If treatments are chosen, patients can start ...
(Date:5/22/2015)... May 22, 2015 Medivo, Inc., a leader ... Rates and Genotype Results in ‘Baby Boomers’ Screened for HCV ... Nationwide Lab Test Database” at Digestive Disease Week, May 16-19, ... Affairs and Analytics team members Carol Smyth, MB; Jason Bhan, ... Parker, MSI, along with Nancy Reau, MD from the University ...
Breaking Medicine News(10 mins):Health News:Amica Has 4 Road Safety Tips for Memorial Day Weekend 2Health News:ZH Healthcare Adds Bill Lane to Advisory Board 2Health News:West Hollywood Dental Office, Sunset Plaza Dental is Now Offering Complimentary Consultations 2Health News:Medivo Study Finds HCV Positivity Rates are 250% Higher Among Baby Boomers 2
... the University of Houston (UH) are recommending a new strategy ... cardiovascular diseases. In an invited review published in ... scientists at the Center for Nuclear Receptors and Cell Signaling ... following the team,s 1996 discovery of the estrogen receptor beta ...
... found a possible explanation for why autistic children act and ... shown that the connections between brain regions that are important ... boys with autism than in non-autistic children. ... Human Brain Mapping, senior author Jennifer G. Levitt, a ...
... This release is available in German ... shown the link between regular exercises and improved health ... in physical activity and public health at the Centre ... of Vienna has investigated this relationship with a meta-study ...
... was honored recently by the Armenian American Health Professional ... both the United States and in Armenia. The award ... Boston University School of Medicine (BUSM) and president of ... of the department of urology at BUSM and chief ...
... released a national strategy for ensuring that environmental, ... and addressed in the fast-growing field of nanotechnology. ... Safety (EHS) Research Strategy provides an integrated research ... the National Nanotechnology Initiative (NNI), the Federal Government,s ...
... A paper from the National Institutes of Health in the ... the frequency of alcohol consumption and the average quantity of ... risk from individual cancers as well as all cancers. ... Health Interview Survey in the US, assessing more than 300,000 ...
Cached Medicine News:Health News:New drug strategies for Alzheimer's, multiple sclerosis examined at UH 2Health News:Autistic brains develop more slowly than healthy brains UCLA researchers say 2Health News:Autistic brains develop more slowly than healthy brains UCLA researchers say 3Health News:Early mortality risk reduced up to 40 percent through increased physical activity and sports 2Health News:Early mortality risk reduced up to 40 percent through increased physical activity and sports 3Health News:Physician honored for medical contributions in US and Armenia 2Health News:Federal government releases environmental, health, and safety research strategy for nanotechnology 2Health News:Federal government releases environmental, health, and safety research strategy for nanotechnology 3Health News:Association of quantity of alcohol and frequency of consumption with cancer mortality 2
(Date:5/22/2015)... Taskforce representing Canada,s living victims of ... the Minister and Health Canada have put into this program ... of the thalidomide survivors, and more than 70% of them ... annual adjustments for inflation. Certain of the thalidomide ... on the severity of their disability, tax free, with inflation ...
(Date:5/22/2015)... , May 22, 2015  Effective staffing ... pharmaceutical brand recognition and success. ... a study to provide pharmaceutical and biotech marketing ... (FTEs and budget) that are being channeled into ... biotech marketing managers can utilize this report to ...
(Date:5/22/2015)... May 22, 2015 The leading companies ... billion global cardiac rhythm management device market dominate ... that Medtronic, St. Jude Medical, Boston Scientific and ... this market segment. The healthcare market research publisher,s ... uses 2015 as a base year, providing forecasts ...
Breaking Medicine Technology:Effective Marketing Services Group Critical for Pharmaceutical Brand Recognition 2Kalorama: Top Companies Dominate Cardiac Defibrillator Market 2Kalorama: Top Companies Dominate Cardiac Defibrillator Market 3Kalorama: Top Companies Dominate Cardiac Defibrillator Market 4
... Cynosure, Inc. (Nasdaq: CYNO ), ... light-based aesthetic treatment systems, today announced that the company will ... on Tuesday, July 26 and host a conference call for ... On the call, President and Chief Executive Officer Michael ...
... Imagenetix, Inc. (OTCBB: IAGX) issued today a shareholders, letter discussing the ... focus for the future. Dear Imagenetix shareholder - ... 31, 2011 and as we commence the new fiscal year, I ... focus for the future.   Over the past few ...
Cached Medicine Technology:Cynosure to Host Second-Quarter 2011 Financial Results Conference Call on July 26 2Imagenetix, Inc. Discusses March 31, 2011 Fiscal Year End Results and Future Focus 2Imagenetix, Inc. Discusses March 31, 2011 Fiscal Year End Results and Future Focus 3
... Thermovent® T helps provide protection to the exposed ... and extremely lightweight making it ideal for active ... high rate of heat and moisture recovery, it ... ,All HMEs and filters have ISO standard tapered ...
... 1991 Intersurgical Incorporated manufactures ... heat and moisture exchangers, ... products, hand-held nebulizers and ... accessories and connectors for ...
... 1991 Intersurgical Incorporated manufactures ... heat and moisture exchangers, ... products, hand-held nebulizers and ... accessories and connectors for ...
... The Ulti-Mist™ HME product line has the ... pediatrics to adults and from intubated patients ... superior humidification for both anesthesia and critical ... HME/Filters provide maximum protection for patients and ...
Medicine Products: