Navigation Links
MIT scientists discover cancer-fighting role for cells
Date:1/19/2011

lled inflammation, which can further damage the surrounding tissue.

Edelman and HST graduate student Joseph Franses hypothesized that endothelial cells might also play a role in controlling cancer behavior, because blood vessels are so closely entwined with tumors. It was already known that other types of cells within tumors, known collectively as the tumor stromal microenvironment, influence cancer cell growth and metastasis, but little was known about how endothelial cells might be similarly involved.

In the new study, Edelman, Franses and former MIT postdoctoral fellows Aaron Baker and Vipul Chitalia showed that secretions from endothelial cells inhibit the growth and invasiveness of tumor cells, both in cells grown in the lab and in mice. Endothelial cells secrete hundreds of biochemicals, many of which may be involved in this process, but the researchers identified two that are particularly important: a large sugar-protein complex called perlecan, and a cytokine called interleukin-6. When endothelial cells secrete large amounts of perlecan but little IL-6 they are effective at suppressing cancer cell invasion, whereas they are ineffective in the opposite proportions.

The researchers theorize that there is a constant struggle between cancer cells and endothelial cells, and most of the time, the endothelial cells triumph. "All of us, every day, are exposed to factors that cause cancer, but relatively few of us exhibit disease," says Edelman. "We believe that the body's control mechanism wins out the bulk of the time, but when the balance of power is reversed cancer dominates."

The struggle also depends on a third player, the endothelial cells' extracellular matrix structural proteins that pave blood vessels and on which the endothelial cells reside. Endothelial cells only function properly when their extracellular matrix is stable and of the correct biochemical composition. Under normal conditions, if a cell becomes cancerous
'/>"/>

Contact: Jessica Holmes
holmesj@mit.edu
617-253-2702
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/26/2015)... 2015 Let’s not lose focus of ... are today’s traffic magnets. Three out of 4 consumers ... their produce department, according to a Packaged Facts survey. ... are looking to add more fruits and vegetables to ... Day is April 2. As featured in the Chase’s ...
(Date:3/26/2015)... North American Seminars launches it new mobile ... providing information regarding OT PT continuing education courses to ... a leader in live hands PT continuing education ... and online continuing education courses. , Featured ... Master Clinicians Approach to Advanced Concepts in Examination and ...
(Date:3/26/2015)... 26, 2015 Florida Hospital teamed up with ... Your Health campaign and live Dr. Oz event, which took ... 21st. More than a thousand people came out to see ... , The world renowned cardiothoracic surgeon and Emmy award ... Hurtado and a panel of experts for the live health ...
(Date:3/26/2015)... March 26, 2015 The Baruch S. ... team of nationally renowned scientists to focus exclusively on ... move that nearly triples its research capacity and has ... on hepatitis B and liver cancer in the United ... Jinhong Chang, Ju Tao Guo and Ying-Hsiu Su – ...
(Date:3/26/2015)... March 26, 2015 “The SWEET Act is ... healthy options more available and help parents who are working ... is a reasonable approach to support public health, and we ... issue for the health of all families,” said Dr. Jane ... Health on the introduction of the Sugar-Sweetened Beverage Tax (SWEET) ...
Breaking Medicine News(10 mins):Health News:North American Seminars Launches Healthclick.com, a New Mobile Ready Website, Providing CME Course Information to PT, PTA, OT and ATC's 2Health News:North American Seminars Launches Healthclick.com, a New Mobile Ready Website, Providing CME Course Information to PT, PTA, OT and ATC's 3Health News:Florida Hospital Welcome Dr. Oz to Tampa and Invites the Community to Attend Educational Seminars Hosted by Florida Hospital Physicians 2Health News:Florida Hospital Welcome Dr. Oz to Tampa and Invites the Community to Attend Educational Seminars Hosted by Florida Hospital Physicians 3Health News:Baruch S. Blumberg Institute Recruits World-Class Hepatitis B Scientists 2Health News:Baruch S. Blumberg Institute Recruits World-Class Hepatitis B Scientists 3Health News:Baruch S. Blumberg Institute Recruits World-Class Hepatitis B Scientists 4Health News:National Alliance for Hispanic Health Statement on Introduction of SWEET Act in 114th Congress 2
... give back to Mercy Ships , ... Garden Valley. TX (Vocus) August ... greatest medal hopes at the Beijing Olympics, racer Paul Goodison, has announced ... medical care to the people of Africa. , , , , ,While ...
... service now available for pet owners and first responders in the ... pet safety company in the Northern Hemisphere, Rover Respond,R™ not only ... and animal rescue groups and provides peace of mind to pet ... ...
... rapid growth in popularity of DNA testing and genetic profiling is ... benefits available from genetic tests outweigh consumers, privacy concerns. From ... testing data to drive health and lifestyle decisions is gaining acceptance. ... ...
... ARE OBESE MAY CARRY ASTHMA TRAIT , A new ... may carry a specific trait or phenotype that causes ... are not obese with asthma. Researchers from Quebec, Canada ... cell counts, symptom perceptions, BMI/waist circumference, and waist-to-hip ratio ...
... ANN ARBOR, Mich., Aug. 4 The Kansas Health ... data system that,will enable the agency to analyze the ... system -- comprised of a data repository and a ... care data for several,state programs. Andy Allison, KHPA,s deputy ...
... nanotechnology, scientists already know that size does matter. , But ... Hill have shown that shape matters even more a ... for treating cancer and other diseases, from diabetes and multiple ... led by Joseph DeSimone, Ph.D., Chancellor,s Eminent Professor of Chemistry ...
Cached Medicine News:Health News:Olympic Sailing Hopeful Backs Hospital Ship Charity 2Health News:Olympic Sailing Hopeful Backs Hospital Ship Charity 3Health News:Olympic Sailing Hopeful Backs Hospital Ship Charity 4Health News:Emergencies Are No Longer Obstacles in Responsible Pet Care 2Health News:Emergencies Are No Longer Obstacles in Responsible Pet Care 3Health News:DNA Testing and Genetic Profiles Help Avoid Broken Hearts Polls Reveal 2Health News:DNA Testing and Genetic Profiles Help Avoid Broken Hearts Polls Reveal 3Health News:Chest Journal: August news briefs 2Health News:Kansas Health Policy Authority Awards Thomson Reuters Contract for Health Care Data Integration and Analysis Initiative 2Health News:Kansas Health Policy Authority Awards Thomson Reuters Contract for Health Care Data Integration and Analysis Initiative 3Health News:UNC study: shape, not just size, impacts effectiveness of emerging nanomedicine therapies 2Health News:UNC study: shape, not just size, impacts effectiveness of emerging nanomedicine therapies 3
(Date:3/26/2015)... SAN ANTONIO and STAEFA, Switzerland ... based on the Venture platform, wirelessly transmits sound from the ... better hearing ear. This allows people with single-sided deafness to ... before. The new fitting process for Phonak CROS II is ... users can instantly experience the benefits of the CROS solution ...
(Date:3/26/2015)... , March 26, 2015  Becton, Dickinson and ... it will commence offers to exchange all validly tendered ... CareFusion Corporation, a wholly owned subsidiary of BD, for ... the table below. A Registration Statement on Form S-4 ... New Notes was filed with the Securities and Exchange ...
(Date:3/26/2015)... 26, 2015  Oxis Biotech, Inc. (OXIS), ... Inc. [OTC: OXIS] and [Euronext Paris: OXI.PA] ... option agreement with the University of Pittsburgh ... Dr. Xiang-Qun Xie , Associate Dean ... School of Pharmacy.  These patents/intellectual properties relate ...
Breaking Medicine Technology:Phonak CROS II: The smart solution for single-sided deafness 2Becton, Dickinson and Company to Commence Exchange Offers 2Becton, Dickinson and Company to Commence Exchange Offers 3Becton, Dickinson and Company to Commence Exchange Offers 4Becton, Dickinson and Company to Commence Exchange Offers 5Oxis Biotech Executes Option Agreement to Certain Patents/Intellectual Properties Owned by the University of Pittsburgh 2Oxis Biotech Executes Option Agreement to Certain Patents/Intellectual Properties Owned by the University of Pittsburgh 3
... DALLAS, Aug. 3 ACCESS PHARMACEUTICALS, INC. ... update today on its clinical development strategy for ProLindac , ... be active in many solid tumors in human clinical studies. Access has ... dose levels and regimens of ProLindac monotherapy in cancer patients, provide additional data ...
... Grammy-Award winning artist and long-time (PRODUCT)RED supporter John Legend ... for his August 13th, 2009 concert at Madison Square Garden in ... Gap stores in the New York tri-state area will include a ... reserved RED(ZONE) section for John Legend,s MSG show. Even better, with ...
Cached Medicine Technology:Access Pharmaceuticals Provides Update on ProLindac Clinical Development Program 2Access Pharmaceuticals Provides Update on ProLindac Clinical Development Program 3Access Pharmaceuticals Provides Update on ProLindac Clinical Development Program 4John Legend and Gap Join (PRODUCT)RED(TM) to Help Eliminate AIDS in Africa with Exclusive (RED)ZONE Seating at Madison Square Garden 2John Legend and Gap Join (PRODUCT)RED(TM) to Help Eliminate AIDS in Africa with Exclusive (RED)ZONE Seating at Madison Square Garden 3
Immunoturbidimetric assay for the quantitative in vitro determination of Lipoprotein (a) in human serum or plasma...
For the quantitative in vitro determination of Digoxin in human serum....
For the quantitative in vitro determination of Microalbumin in urine....
Quantitative determination of Fibrinogen (Clauss Method). Freeze-dried human thrombin (~100NIH units/mL) with heparin inhibitor and calcium....
Medicine Products: