Navigation Links
MIT engineers design new nanoparticle that could lead to vaccines for HIV, malaria, other diseases
Date:2/22/2011

CAMBRIDGE, Mass.- MIT engineers have designed a new type of nanoparticle that could safely and effectively deliver vaccines for diseases such as HIV and malaria.

The new particles, described in the Feb. 20 issue of Nature Materials, consist of concentric fatty spheres that can carry synthetic versions of proteins normally produced by viruses. These synthetic particles elicit a strong immune response comparable to that produced by live virus vaccines but should be much safer, says Darrell Irvine, author of the paper and an associate professor of materials science and engineering and biological engineering.

Such particles could help scientists develop vaccines against cancer as well as infectious diseases. In collaboration with scientists at the Walter Reed Army Institute of Research, Irvine and his students are now testing the nanoparticles' ability to deliver an experimental malaria vaccine in mice.

Vaccines protect the body by exposing it to an infectious agent that primes the immune system to respond quickly when it encounters the pathogen again. In many cases, such as with the polio and smallpox vaccines, a dead or disabled form of the virus is used. Other vaccines, such as the diphtheria vaccine, consist of a synthetic version of a protein or other molecule normally made by the pathogen.

When designing a vaccine, scientists try to provoke at least one of the human body's two major players in the immune response: T cells, which attack body cells that have been infected with a pathogen; or B cells, which secrete antibodies that target viruses or bacteria present in the blood and other body fluids.

For diseases in which the pathogen tends to stay inside cells, such as HIV, a strong response from a type of T cell known as "killer" T cell is required. The best way to provoke these cells into action is to use a killed or disabled virus, but that cannot be done with HIV because it's difficult to render t
'/>"/>

Contact: Caroline McCall
cmccall5@mit.edu
617-253-1682
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Tissue engineers create a new way to assemble artificial tissues
2. Engineers turn noise into vision
3. Nanoscale stealth probe slides into cell walls seamlessly, say Stanford engineers
4. Artists, Product Designers, Printing Gurus, Game Developers, Manufacturing Engineers Will Converge at RAPID 2010/3D IMAGING Conference/Expo, May 18-20 in LA
5. Quest for designer bacteria uncovers a Spy
6. Biodesign hosts international consortium on screening for lung cancer
7. Next-generation hospital design can improve health -- and save money
8. Indoor plant intervention: New answers for health care design?
9. Structure of key molecule in immune system provides clues for designing drugs
10. Better Helmet Design Might Lower Soldiers Risk for Brain Injury
11. UM researchers are studying child-mother interactions to design robots with social skills
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... Randy Dotinga HealthDay Reporter ... powerful drug combo may not be as effective against ... human cells suggests that one of the medications might ... study,s findings aren,t definitive, and there,s still hope for ... lumacaftor, according to the study,s senior author. "The ...
(Date:7/23/2014)... Newark, NJ (PRWEB) July 23, 2014 ... Foundation for New Jersey today announced the awarding of ... including a special award in recognition of the Foundation’s ... is proud to continue our tradition of supporting community-based ... enhance the quality of life in the Garden State,” ...
(Date:7/23/2014)... 23, 2014 (HealthDay News) -- Regularly checking the pulse ... researchers report. "Screening pulse is the method of ... age 65 who have never had a stroke. Our ... and easy way to identify people who might need ... study author Dr. Bernd Kallmunzer, of Erlangen University in ...
(Date:7/23/2014)... Coral, FL (PRWEB) July 23, 2014 Rich ... announce the success of their charity yard sale to support ... was raised and 100% of the proceeds will be donated ... at the event are being donated to the Habitat for ... Fort Myers, Florida 33903. , One of the highlights ...
(Date:7/23/2014)... Lauderdale, FL (PRWEB) July 23, 2014 ... the largest online retailer of nutritional supplements, has officially ... Awards. BPI SPORTS , the fastest growing sports ... following categories: , Brand of the Year, Best Tasting ... the Year, Protein Powder of the year - Whey-HD™, ...
Breaking Medicine News(10 mins):Health News:Cystic Fibrosis Drug Combo May Be Less Effective Than Hoped 2Health News:Cystic Fibrosis Drug Combo May Be Less Effective Than Hoped 3Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 2Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 3Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 4Health News:The Horizon Foundation for New Jersey Awards More than $1 million in Grants to 20 Non-profit Organizations 5Health News:Routine Pulse Check May Prevent Second Stroke, Study Says 2Health News:Rich Dad Education Charity Yard Sale Raises Over $650 for Habitat for Humanity of Lee and Hendry Counties 2Health News:Vote Now; BPI SPORTS is Nominated for Eight 2014 Bodybuilding.com Supplement Awards 2Health News:Vote Now; BPI SPORTS is Nominated for Eight 2014 Bodybuilding.com Supplement Awards 3
... and researcher at the Johns Hopkins Berman Institute of Bioethics ... placed around the donation and banking of human biological material, ... material,s use and address donor expectations before research begins. ... All of Me? Reflections on The Immortal Life of Henrietta ...
... Active ... , ... -- The Active Search Results Search Engine ( www.activesearchresults.com ) announced today its new search ... ,ASR Ranking allows search engines to rank search results higher for websites where the owners ...
... of 2010, as many as 17 percent of children ... health care needs. Behavioral issues, developmental disorders, cognitive disorders, ... risk of developing oral disease, according to an article ... Dentistry , the peer-reviewed clinical journal of the Academy ...
... ... Physicians and Health Care Providers will monetize their time and streamline their patient communication, that ... sixty days. , ... June 21, 2010 -- DocGreet.com is so sure that the services available to Doctors, Physicians ...
... viral for bacterial infections, review found , MONDAY, ... one who can,t always tell if your child has ... for antibiotics: Pediatricians say this is the most common ... Other common missed or mistaken diagnoses include those involving ...
... much of something is due to our genes and how ... in the academic journal Addiction shows that the ... or use drugs, for two related reasons. First, a ... also predisposed to choose friends who smoke, drink, or use ...
Cached Medicine News:Health News:Scholar calls for a new legal, ethical framework for research with human tissue specimens 2Health News:Scholar calls for a new legal, ethical framework for research with human tissue specimens 3Health News:Scholar calls for a new legal, ethical framework for research with human tissue specimens 4Health News:Active Search Results Announces its New Search Engine Ranking Algorithm 2Health News:Active Search Results Announces its New Search Engine Ranking Algorithm 3Health News:Children with special needs are at increased risk for oral disease 2Health News:DocGreet Guarantees More Time and Money to Doctors and Health Care Providers 2Health News:More Than Half of Pediatricians Make Diagnostic Errors: Survey 2Health News:More Than Half of Pediatricians Make Diagnostic Errors: Survey 3Health News:New research shows peer drug use may increase an individual's genetic tendency to use drugs 2
(Date:7/23/2014)... 2014 PositiveID Corp. (OTCQB: PSID), based in ... an emerging player in the bio-threat detection market, ... and rapid medical testing. The Company,s proprietary airborne ... Networked Detector), was developed under contract with the ... Technology directorate, and $30 million of contract funding. ...
(Date:7/23/2014)... Pa. , July 23, 2014 /PRNewswire/ ... today announced successful results from its randomized, ... in women with biopsy-proven cervical intraepithelial neoplasia ... types 16 or 18. Treatment with VGX-3100, ... of CIN2/3 to CIN1 or no disease, ...
(Date:7/23/2014)... -- Nearly 8,000 attendees will converge in Washington ... Conference (RBC), taking place July 23-26 at the Gaylord ... pharmacists to "Lead Change" in the pharmacy profession, in ... their future. "RBC is the perfect opportunity ... and learn new ways they can lead change in ...
Breaking Medicine Technology:PositiveID Analyst Inspection: Emerging Contender in BioThreat Detection - First Ever Revenue Guidance and Backlog Position Company for Increased Visibility and Traction - by SmallCapTraders.com 2Inovio Pharmaceuticals HPV Immunotherapy Achieves Primary Efficacy Endpoint in Randomized Phase II Cervical Dysplasia Trial 2Inovio Pharmaceuticals HPV Immunotherapy Achieves Primary Efficacy Endpoint in Randomized Phase II Cervical Dysplasia Trial 3Inovio Pharmaceuticals HPV Immunotherapy Achieves Primary Efficacy Endpoint in Randomized Phase II Cervical Dysplasia Trial 4Inovio Pharmaceuticals HPV Immunotherapy Achieves Primary Efficacy Endpoint in Randomized Phase II Cervical Dysplasia Trial 5Cardinal Health Encourages Independent Pharmacists to Lead Change at 24th Annual Retail Business Conference 2Cardinal Health Encourages Independent Pharmacists to Lead Change at 24th Annual Retail Business Conference 3Cardinal Health Encourages Independent Pharmacists to Lead Change at 24th Annual Retail Business Conference 4Cardinal Health Encourages Independent Pharmacists to Lead Change at 24th Annual Retail Business Conference 5Cardinal Health Encourages Independent Pharmacists to Lead Change at 24th Annual Retail Business Conference 6
...  Responding to a need for better post-market surveillance of orthopedic ... Consortium of Orthopaedic Registries in October 2010. As ... Journal of Bone and Joint Surgery , ... for improving the safety of orthopedic devices using outcomes registries ...
... Dec. 21, 2011 Senate Democratic Leader John L. ... and CEO of Walgreens Inc., expressing his dismay about ... drug coverage more affordable for many of the low-income ... Walgreens has administered the program through Express Scripts, ...
Cached Medicine Technology:Unprecedented International Effort Seeks to Improve Safety of Orthopedic Devices 2Unprecedented International Effort Seeks to Improve Safety of Orthopedic Devices 3Unprecedented International Effort Seeks to Improve Safety of Orthopedic Devices 4
The KMedic Jet Wire Twister is designed to provide fast, smooth and even twisting of soft wire, saving time in the O.R. Now available for the first time in stainless steel. Suitable for the entire ra...
Lead filled and faced bone mallet used to exert force on osteotomes, chisels, and gouges....
Slightly curved Periosteal elevator....
Straight chisel for scoring, cutting, scraping, cleaning and sculpting bone....
Medicine Products: