Navigation Links
MIT develops thin-film 'micro pharmacy'
Date:2/11/2008

CAMBRIDGE, Mass.--A new thin-film coating developed at MIT can deliver controlled drug doses to specific targets in the body following implantation, essentially serving as a micro pharmacy.

The film could eventually be used to deliver drugs for cancer, epilepsy, diabetes and other diseases. It is among the first drug-delivery coatings that can be remotely activated by applying a small electric field.

You can mete out what is needed, exactly when it's needed, in a systematic fashion, said Paula Hammond, the Bayer Professor of Chemical Engineering and senior author of a paper on the work appearing in the Feb. 11 issue of the Proceedings of the National Academy of Sciences.

The film, which is typically about 150 nanometers (billionths of a meter) thick, can be implanted in specific parts of the body.

The films are made from alternating layers of two materials: a negatively charged pigment and a positively charged drug molecule, or a neutral drug wrapped in a positively charged molecule.

The pigment, called Prussian Blue, sandwiches the drug molecules and holds them in place. (Part of the reason the researchers chose to work with Prussian Blue is that the FDA has already found it safe for use in humans.)

When an electrical potential is applied to the film, the Prussian Blue loses its negative charge, which causes the film to disintegrate, releasing the drugs. The amount of drug delivered and the timing of the dose can be precisely controlled by turning the voltage on and off.

The electrical signal can be remotely administered (for example, by a physician) using radio signals or other techniques that have already been developed for other biomedical devices.

The films can carry discrete packets of drugs that can be released separately, which could be especially beneficial for chemotherapy. The research team is now working on loading the films with different cancer drugs.

Eventually, devices could be designed that can automatically deliver drugs after sensing that they're needed. For example, they could release chemotherapy agents if a tumor starts to regrow, or deliver insulin if a diabetic patient has high blood sugar.

You could eventually have a signaling system with biosensors coupled with the drug delivery component, said Daniel Schmidt, a graduate student in chemical engineering and one of the lead authors of the paper.

Other lead authors are recent MIT PhD recipients Kris Wood, now a postdoctoral associate at the Broad Institute of MIT and Harvard, and Nicole Zacharia, now a postdoctoral associate at the University of Toronto.

Because the films are built layer by layer, it is easy to control their composition. They can be coated onto a surface of any size or shape, which offers more design flexibility than other drug-delivery devices that have to be microfabricated.

The drawback to microfabricated devices is that it's hard to coat the drug over a large surface area or over an area that is not planar, said Wood.

Another advantage to the films is that they are easy to mass-produce using a variety of techniques, said Hammond. These thin-film systems can be directly applied or patterned onto 3D surfaces such as medical implants.


'/>"/>

Contact: Elizabeth Thomson
thomson@mit.edu
617-258-5402
Massachusetts Institute of Technology
Source:Eurekalert

Related medicine news :

1. Capsulated Systems, Inc. Develops Long Term Local Anesthetic
2. OHSU Cancer Institute researcher develops test for targeted therapy in acute myeloid leukemia
3. Silverchair Learning Systems Updates and Develops New Courses
4. Biomarkers predict risk for invasive breast cancer years before the tumor develops
5. UCLA doctor develops new technique to treat varicose veins
6. Corey McPherson Nash Develops Case Statement for Dana-Farber Cancer Institute Capital Campaign
7. Couples more likely to divorce if spouse develops cervical or testicular cancer
8. NeoStrata Clinical Findings Reveal Benefits of Combining Glycolic Acid Peels and Targeted Home Care With Microdermabrasion for Optimized Treatment of Photodamaged Skin
9. Dblur Concludes Licensing Deal With STMicroelectronics
10. Microsoft Dynamics CRM 4.0 Users now can include Telephony and Call Recording features by adding ConversationPRO(TM) from VoiceGate, a Division of IgeaCare Systems Inc.
11. Opportunity Internationals Micro Insurance Agency to Develop and Provide Life, Health and Crop Insurance for 21 Million Poor People
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2017)... , ... February 28, 2017 , ... ... premiere organization in North America for the scientific development, healthcare training and clinical ... Annual Meeting & Scientific Session on September 16-17 in Greenville, SC at the ...
(Date:2/28/2017)... Lake City, Utah (PRWEB) , ... February 28, 2017 , ... ... Month is a time for everyone to reaffirm their commitment to improving cardiovascular health ... cause of death for men and women. Every year, one in four deaths are ...
(Date:2/28/2017)... ... February 28, 2017 , ... Roxanna ... 4:30-5:30 p.m. at the 11th Annual RISE Nashville Summit. RISE Nashville is the ... analytics, and engagement strategies. , The discussion will include best practices for accurate ...
(Date:2/27/2017)... ... ... Robert E. Burke, MD, PhD, had a successful career as a pediatrician and ... have led him down a much different path. , In his book, “Beyond the ... Dr. Burke shares a personal account of the tribulations he encountered on his path ...
(Date:2/27/2017)... ... 2017 , ... Elisa Guajardo Carothers is not your typical author. She went from working as ... Now, she writes about God, when she isn’t swimming as a performing mermaid. , Her ... BS! (Before Satan),” she offers a comedic look at the dysfunctions of God’s family, before ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... 27, 2017  A landmark study led ... MBBS, PhD, FRACS, of  Sydney Heart and Lung ... will be published in the February 28, 2017 issue ... College of Cardiology . According to the study, which involved 37,720 ... surgery technique (anOPCABG) reduced postoperative stroke by ...
(Date:2/27/2017)... TAMPA, Fla. , Feb. 27, ... medical device company focused on developing cerebral embolic ... the members of the FDA,s Circulatory System Devices ... acknowledgement of the need for cerebral protection following ... "The statements shared by this FDA panel support ...
(Date:2/27/2017)... -- Now in its seventh year, the Pharmaceutical ... successful at developing and commercialising innovation. ... The Index can be summarised ... two different companies in early phase, which would make the ... of each company,s performance between 2011 and 2016, the 2017 ranking sees ...
Breaking Medicine Technology: