Navigation Links
MIT biologists pinpoint a genetic change that helps tumors move to other parts of the body
Date:4/6/2011

CAMBRIDGE, Mass. -- MIT cancer biologists have identified a genetic change that makes lung tumors more likely to spread to other parts of the body. The findings, to be published in the April 6 online issue of Nature, offers new insight into how lung cancers metastasize and could help identify drug targets to combat metastatic tumors, which account for 90 percent of cancer deaths.

The researchers, led by Tyler Jacks, director of the David H. Koch Institute for Integrative Cancer Research at MIT, found the alteration while studying a mouse model of lung cancer. They then compared their mouse data to genetic profiles of human lung tumors and found that reduced activity of the same gene, NKX2-1, is associated with higher death rates for lung-cancer patients.

This study represents an important step in understanding how changes that disable this gene would make tumors more aggressive, says Monte Winslow, a senior postdoctoral associate in Jacks' lab and lead author of a paper.

Understanding the role of NKX2-1 may help scientists pursue drugs that could counteract its loss. Right now, "the sad reality is that if you could tell a patient whether their cancer has turned down this gene, you would know they will have a worse outcome, but it wouldn't change the treatment," Winslow says.

Winslow and his colleagues at the Koch Institute studied mice that are genetically programmed to develop lung tumors. The mice's lung cells can be induced to express an activated form of the cancer-causing gene Kras, and the tumor suppressor gene p53 is deleted. While all of those mice develop lung tumors, only a subset of those tumors metastasizes, suggesting that additional changes are required for the cancer to spread.

The researchers analyzed the genomes of metastatic and non-metastatic tumors in hopes of finding some genetic differences that would account for the discrepancy. The absence of NKX2-1 activity in metastatic tumors was
'/>"/>

Contact: Patti Richards
prichards@mit.edu
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Biologists discover control center for sperm production
2. National Academy of Sciences honors microbiologists for major scientific contributions
3. Biologists, educators recognize excellence in evolution education
4. Caltech biologists discover microRNAs that control function of blood stem cells
5. U. Iowa biologists publish findings on cell interactions
6. Physicists help biologists to understand protein folding
7. Researchers pinpoint genetic pathways involved in breast cancer
8. Researchers pinpoint patients who receive greatest benefit from heart failure treatment
9. Researchers pinpoint origin of deadly brain tumor
10. York U study pinpoints part of brain that suppresses instinct
11. Using CT, radiologists can pinpoint cause of some strokes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... December 22, 2014 Fad diets ... The reason why most fad diets have hung around ... problem with fad diets is that, as the body becomes ... dieter uncertain of how to reset the metabolism to return ... Diet Doc developed their all-inclusive diet plans that ...
(Date:12/22/2014)... York, New York (PRWEB) December 22, 2014 ... are a staple of the season. Many may be thinking ... in a span of a few weeks. Health Republic Insurance ... help of Registered Dietitian, Andrea Chernus, to provide some smart ... eat and stay healthy. , 1)    Avoid arriving at a holiday ...
(Date:12/22/2014)... 2014 The Bob Woodruff Foundation ... invested more than $5 million in programs and ... their families. , This includes $1.3 million in ... helping with: veteran entrepreneurship; community impact; vocational training; ... severely injured veterans. , “The needs of those ...
(Date:12/22/2014)... 2014 In recognition of Veteran’s Day, ... Hero Reward, a local organization that provides services to ... , Located on a couple hundred acres in the ... lodging, world class fishing, hunting, hiking, horseback riding, 4-wheeling, ... several years ago to support U.S. Service men and ...
(Date:12/22/2014)... TX (PRWEB) December 22, 2014 TheHardwareCity.com ... work glove with many useful features. Customers of the ... can have the new gloves delivered to their home ... gear and hand tools that incorporate heavy duty magnets, ... Magnetic Glove allows workers to store metal parts on ...
Breaking Medicine News(10 mins):Health News:Diet Doc Announces the Difference Between Fad Diets and Real Weight Loss Programs to Help Dieters Make the Best Choice 2Health News:Diet Doc Announces the Difference Between Fad Diets and Real Weight Loss Programs to Help Dieters Make the Best Choice 3Health News:Diet Doc Announces the Difference Between Fad Diets and Real Weight Loss Programs to Help Dieters Make the Best Choice 4Health News:Health Republic Insurance of New York Offers Five Simple Tips to Eat Healthy During the Holidays 2Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 2Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 3Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 4Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 5Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 6Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 7Health News:Discount Labels Donates Portion of November Sales to Hero Reward Program 2Health News:MagnoGrip Pro Utility Magnetic Gloves on Sale at TheHardwareCity.com 2
... Sciences' Institute of Medicine released a report recommending ... the school environment, such as a la carte ... National Dairy Council (NDC) applauds the overall recommendations ... of nonfat and low-fat dairy products, fruits, vegetables ...
... are blind to the perils of imported eye cosmetics//. ... such eye makeup products known as kajal, kohl and surma ... These products used traditionally by ladies to beautify the eyes ... toxin. Lead poisoning can lead to cognitive ...
... most comprehensive look at genetic risk factors for type ... close collaboration with two other groups, has identified// at ... of diabetes and confirmed existence of another six. The ... the online edition of the journal Science, boost to ...
... a cure for the dreaded elephantiasis, Finnish scientists say. Finnish ... elephantiasis. And if only they could check the spread of ... a lasting cure for the dreaded elephantiasis. They ... than 100 km from the Arctic Circle. "From trying to ...
... Researchers from MetroHealth Medical Center and Case Western Reserve ... who have had previous spontaneous preterm births with 17 ... another preterm birth would consequently reduce both short-term and ... year. The results of their study are reported in ...
... Despite widespread capacity to provide prescription medication labels in ... do so and as a result//, limited-English patients face ... by The New York Academy of Medicine presented today ... Internal Medicine (SGIM) in Toronto, Ontario. ,"Imagine, ...
Cached Medicine News:Health News:National Academy of Sciences' Institute of Medicine Report Calls for More Dairy Foods at School 2Health News:Researchers Identify New Genetic Risk Factors for Type 2 Diabetes 2Health News:Researchers Identify New Genetic Risk Factors for Type 2 Diabetes 3Health News:Researchers Identify New Genetic Risk Factors for Type 2 Diabetes 4Health News:Researchers Identify New Genetic Risk Factors for Type 2 Diabetes 5Health News:Researchers Identify New Genetic Risk Factors for Type 2 Diabetes 6Health News:Reindeers Could Hold the Key to Elephantiasis Cure 2Health News:Reindeers Could Hold the Key to Elephantiasis Cure 3Health News:Drug Therapy can Reduce Preterm Births and Decrease Lifetime Medical Costs 2Health News:Many NYC Pharmacies Fail to Translate Prescription Labels for Patients Who Don't Understand English 2Health News:Many NYC Pharmacies Fail to Translate Prescription Labels for Patients Who Don't Understand English 3
(Date:12/19/2014)... , Dec. 19, 2014 You,re visiting ... checkup and cleaning when he or she says you ... probably heard before, you may have several questions and ... be relieved to know it,s nothing to worry about. ... patients, questions and alleviate any anxiety the public may ...
(Date:12/19/2014)... , Dec. 19, 2014   Hospira, Inc. ... provider of injectable drugs and infusion technologies, today announced ... 33rd Annual Healthcare Conference on Wednesday, Jan. 14, 2015, ... is scheduled to begin at 10:30 a.m. Pacific time ... to all interested parties through a live audiocast accessible ...
(Date:12/19/2014)... 19, 2014  Monarch America Inc. (OTCQB: CANK) ("Monarch ... pleased to provide this review of the Company,s recent ... "Over this past year, we achieved many ... extremely proud to say that Monarch America is in ... has ever been," stated Eric Hagen , CEO ...
Breaking Medicine Technology:Root Canals Have Become More Routine 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 3
... Mass., Sept. 16, 2011 Hologic, Inc. (Hologic or ... developer, manufacturer and supplier of premium diagnostic products, medical ... healthcare needs of women, will focus on two new, ... International Papillomavirus Conference & Clinical Workshop (IPV) ...
... Siemens has appointed Kurt D. Bettenhausen Senior Vice ... research & development (R&D) division. Siemens Corporate Research ... emerging technologies, including new imaging processes that allow ... efficiency to reduce building energy consumption, and renewable ...
Cached Medicine Technology:Hologic Launches Automated Cervical Cancer Screening Solutions at IPV Meeting in Berlin 2Hologic Launches Automated Cervical Cancer Screening Solutions at IPV Meeting in Berlin 3Hologic Launches Automated Cervical Cancer Screening Solutions at IPV Meeting in Berlin 4Siemens Appoints New R&D Head for the U.S. 2
The ImagingPlanet 70 mm Surgical Microscope Adapter. Superior optical quality and precise engineering make this 70 mm focal length adapter an excellent decision for use with your Leica surgical micr...
... Optronics MicroFire - Monochrome: An ... microscope camera with Firewire connectivity. ... imaging beyond 900nm. The camera ... a C-mount adapter and is ...
... the most technologically advanced Micro-dermabrasion machine ... USA after extensive research, it offers ... with maximum control and total flexibility ... to traditional methods because the complex ...
The Urine Legionella Antigen ELISA kit detects the presence of Legionella pneumophila serogroup1 antigen in urine....
Medicine Products: