Navigation Links
MIT: Stem cells could drive hepatitis research forward
Date:2/1/2012

rowing them on special micropatterned plates that direct their organization. These liver cells can be infected with hepatitis C, but they cannot be used to proactively study the role of genetic variation in viral responses because they come from organs that have been donated for transplantation and represent only a small population.

To make cells with more genetic variation, Bhatia and Rice decided to team up with Duncan, who had shown that he could transform iPSCs into liver-like cells.

Such iPSCs are derived from normal body cells, often skin cells. By turning on certain genes in those cells, scientists can revert them to an immature state that is identical to embryonic stem cells, which can differentiate into any cell type. Once the cells become pluripotent, they can be directed to become liver-like cells by turning on genes that control liver development.

In the current paper, MIT postdoc Robert Schwartz and graduate student Kartik Trehan took those liver-like cells and infected them with hepatitis C. To confirm that infection had occurred, the researchers engineered the viruses to secrete a light-producing protein every time they went through their life cycle.

Genetic differences

The researchers' ultimate goal is to take cells from patients who had unusual reactions to hepatitis C infection, transform those cells into liver cells and study their genetics to see why they responded the way they did. "Hepatitis C virus causes an unusually robust infection in some people, while others are very good at clearing it. It's not yet known why those differences exist," Bhatia says.

One potential explanation is genetic differences in the expression of immune molecules such as interleukin-28, a protein that has been shown to play an important role in the response to hepatitis infection. Other possible factors include cells' expression of surface proteins that enable the virus to enter the cells, and cells' suscept
'/>"/>

Contact: Caroline McCall, MIT Media Relations
cmccall5@mit.edu
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New Study Uses Adult Stem Cells in Effort to Save Limbs of Patients with Peripheral Arterial Disease
2. New study suggests stem cells sabotage their own DNA to produce new tissues
3. Attacking cancer cells with hydrogel nanoparticles
4. UCR researcher identifies mechanism malaria parasite uses to spread in red blood cells
5. Pittsburgh Neurosurgeons Explore Use of Drug that Illuminates Brain Tumor Cells To Guide Surgery
6. New tool illuminates connections between stem cells and cancer
7. Bitter melon extract attacks breast cancer cells
8. Heart Stem Cells Move Closer to Human Treatments
9. Notch-blocking drugs kill brain cancer stem cells, yet multiple therapies may be needed
10. Cells of aggressive leukemia hijack normal protein to grow
11. Periodontal pathogens enhance HIV-1 promoter activation in T cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)... FRIDAY, Oct. 24, 2014 (HealthDay News) -- Not getting ... of ulcerative colitis, a new study suggests. Those ... to eight hours per night may be more prone ... the intestines, researchers report. The study authors concluded that ... be considered among patients with inflammatory bowel diseases. ...
(Date:10/25/2014)... 24, 2014 (HealthDay News) -- October,s shorter, darker days ... affective disorder, according to an expert. People ... feel overly tired, lack motivation and even have trouble ... lead to suicide, said Dr. Angelos Halaris, a professor ... Loyola University Chicago Stitch School of Medicine. "Seasonal ...
(Date:10/22/2014)... Arbor, MI (PRWEB) October 22, 2014 ... of Schools of Allied Health Professions (ASAHP) Conference on ... Founder and CEO will participate in a panel discussion ... and Practice. , Isabel Healthcare provides a diagnostic decision ... in improving the diagnosis skills of students and clinical ...
(Date:10/22/2014)... Va. (PRWEB) October 22, 2014 ... Innovation , which is dedicated to distribute health ... of healthcare delivery worldwide announced the development of ... which patients expect when receiving healthcare. These are ... for patient-centered care: “providing care that is respectful ...
(Date:10/22/2014)... Plano, Texas (PRWEB) October 22, 2014 ... convenience of completing their continuing education at home ... now have access to 20 brand new, premium ... HomeCEUConnection.com’s robust catalog of over 2,000 hours ... to fully customize their educational experience. With such ...
Breaking Medicine News(10 mins):Health News:Sleep Duration Linked to Ulcerative Colitis Risk in Study 2Health News:Dark Days Here for Folks With Seasonal Depression 2Health News:Isabel Healthcare to Participate in The Association of Schools of Allied Health Professions (ASAHP) 2014 Conference 2Health News:The Sullivan Institute for Healthcare Innovation Announces Release of Guiding Principles for Patient Experience-Centered Care 2Health News:Top Provider of Continuing Education at Home Releases 20 New Online Courses 2
... What: In recognition of November ... LOJN ) has hosted an educational podcast ( ... Alzheimer,s including: , The rising incidence of Alzheimer,s ... people with Alzheimer,s and their caregivers Risks such ...
... Inc. (Nasdaq: SLTM ), a global leader in the ... ended September 30, 2009. Revenue for the quarter was in-line ... for the third quarter was $17.8 million, an increase of ... quarter 2008 reflecting increased revenue as a result of the ...
... high rate of premature births , TUESDAY, Nov. ... mortality, the United States lags dismally behind most other ... of babies delivered prematurely, according to a new government ... the world in infant mortality," said Marian F. MacDorman, ...
... stage small cell lung cancer(LSCL) with a combination of ... opening the door to larger scale investigation, according to ... Anderson Cancer Center. The Phase II study was ... the annual meeting of the American Society for Radiation ...
... ... started posting surgical videos as part of a new section on its website called ... chest syndrome in pediatric patients. As part the new portion of Baptist,s website to ... of video. , ...
... , SHENZHEN, China, Nov. 3 /PRNewswire-Asia-FirstCall/ ... Nepstar" or the "Company"), the largest,drugstore chain in China based ... has entered into a strategic cooperation agreement,with ATMU (China) Technology ... ATM operators in China, to install ATMs in Nepstar stores. ...
Cached Medicine News:Health News:November is National Alzheimer's Awareness Month 2Health News:Solta Medical Reports Third Quarter 2009 Results 2Health News:Solta Medical Reports Third Quarter 2009 Results 3Health News:Solta Medical Reports Third Quarter 2009 Results 4Health News:Solta Medical Reports Third Quarter 2009 Results 5Health News:Solta Medical Reports Third Quarter 2009 Results 6Health News:Solta Medical Reports Third Quarter 2009 Results 7Health News:Solta Medical Reports Third Quarter 2009 Results 8Health News:Solta Medical Reports Third Quarter 2009 Results 9Health News:Solta Medical Reports Third Quarter 2009 Results 10Health News:CDC Finds U.S. 30th in Infant Mortality 2Health News:CDC Finds U.S. 30th in Infant Mortality 3Health News:Study of concurrent radiotherapy, chemotherapy shows promise in small cell lung cancer 2Health News:Study of concurrent radiotherapy, chemotherapy shows promise in small cell lung cancer 3Health News:New Video Post Shows Minimally Invasive Procedure To Correct Sunken Chest Syndrome 2Health News:China Nepstar Enters Into Strategic Cooperation Agreement with ATMU to Install More Than 1,000 ATMs in Nepstar Stores 2Health News:China Nepstar Enters Into Strategic Cooperation Agreement with ATMU to Install More Than 1,000 ATMs in Nepstar Stores 3
(Date:10/22/2014)... Investor-Edge has initiated coverage on the following ... Progenics Pharmaceuticals Inc. (NASDAQ: PGNX ), Threshold ... Inc. (NASDAQ: IDRA ), and Merrimack Pharmaceuticals ... can be accessed at: http://investor-edge.com/register . ... at 4,419.48, up 2.40%, the Dow Jones Industrial Average ...
(Date:10/22/2014)... RPh, of Vernak Farms Pharmacy in Skaneateles, ... Roentsch Scholarship by the Professional Compounding Centers of America ... during PCCA,s International Seminar, held October 8-10, ... pharmacist and PCCA member who embodies the innovative and ... pharmacist in the compounding community. George ...
(Date:10/22/2014)... Oct. 22, 2014 Moms are ready to ... for themselves and their kids, according to the results ... & Fitness Go Mobile for Moms, the latest installment ... the number 1 pregnancy and parenting web and mobile ... percent of moms surveyed say they can,t think of ...
Breaking Medicine Technology:Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 2Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 3Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 4Market Momentum on Biotech Stocks - Amicus Therapeutics, Progenics Pharma, Threshold Pharma, Idera Pharma, and Merrimack Pharma 5PCCA Awards Charlene Vernak, RPh, the George Roentsch Scholarship 2BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 2BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 3BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 4
... Bulb Direct has been ... Internet since 1996, and we ... 100% satisfaction guarantee. Check out ... and see our discount light ...
With the Symphony family of Pacemakers, Ela presents the most advanced technology on the market. Symphony, lighter than a passport, will take your patients further, offering fast follow-up, using new...
With the Symphony family of Pacemakers, Ela presents the most advanced technology on the market. Symphony, lighter than a passport, will take your patients further, offering fast follow-up, using new...
.90mm (20G) guillotine cutting probe with 1.4mm (17G) removable irrigation sleeve...
Medicine Products: