Navigation Links
MIT: Stem cells could drive hepatitis research forward
Date:2/1/2012

CAMBRIDGE, Mass. -- Hepatitis C, an infectious disease that can cause inflammation and organ failure, has different effects on different people. But no one is sure why some people are very susceptible to the infection, while others are resistant.

Scientists believe that if they could study liver cells from different people in the lab, they could determine how genetic differences produce these varying responses. However, liver cells are difficult to obtain and notoriously difficult to grow in a lab dish because they tend to lose their normal structure and function when removed from the body.

Now, researchers from MIT, Rockefeller University and the Medical College of Wisconsin have come up with a way to produce liver-like cells from induced pluripotent stem cells, or iPSCs, which are made from body tissues rather than embryos; the liver-like cells can then be infected with hepatitis C. Such cells could enable scientists to study why people respond differently to the infection.

This is the first time that scientists have been able to establish an infection in cells derived from iPSCs a feat many research teams have been trying to achieve. The new technique, described this week in the Proceedings of the National Academy of Sciences, could also eventually enable "personalized medicine": Doctors could test the effectiveness of different drugs on tissues derived from the patient being treated, and thereby customize therapy for that patient.

The new study is a collaboration between Sangeeta Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and Electrical Engineering and Computer Science at MIT; Charles Rice, a professor of virology at Rockefeller; and Stephen Duncan, a professor of human and molecular genetics at the Medical College of Wisconsin.

Stem cells to liver cells

Last year, Bhatia and Rice reported that they could induce liver cells to grow outside the body by g
'/>"/>

Contact: Caroline McCall, MIT Media Relations
cmccall5@mit.edu
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New Study Uses Adult Stem Cells in Effort to Save Limbs of Patients with Peripheral Arterial Disease
2. New study suggests stem cells sabotage their own DNA to produce new tissues
3. Attacking cancer cells with hydrogel nanoparticles
4. UCR researcher identifies mechanism malaria parasite uses to spread in red blood cells
5. Pittsburgh Neurosurgeons Explore Use of Drug that Illuminates Brain Tumor Cells To Guide Surgery
6. New tool illuminates connections between stem cells and cancer
7. Bitter melon extract attacks breast cancer cells
8. Heart Stem Cells Move Closer to Human Treatments
9. Notch-blocking drugs kill brain cancer stem cells, yet multiple therapies may be needed
10. Cells of aggressive leukemia hijack normal protein to grow
11. Periodontal pathogens enhance HIV-1 promoter activation in T cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... (PRWEB) April 27, 2015 According to ... and Craniofacial Research), after chronic back pain, TMJ disorders ... resulting in pain and disability. In addition, the report ... percent of the population, costing an estimated 4 billion ... million Americans suffering from seemingly unrelated symptoms such as ...
(Date:4/27/2015)... 2015 As ISO 27001 has quickly ... companies of all sizes and in all industries, Pivot ... prepare for ISO 27001 certification. The information security audit ... them for ISO 27001 certification. Pivot Point's commitment to ... the number of Lead Implementers and Auditors the company ...
(Date:4/27/2015)... Guided by the extensive work of its ... its collaboration with organizations around the world to identify ... eight essential actions for organizations committed to patient ... and systems committed to providing the best in experience ... leadership with committed time and focused intent to shape ...
(Date:4/27/2015)... FMC Corporation’s Health and Nutrition business announced ... market leading ingredients and solutions at Vitafoods Europe from ... Europe 2015 expects to host 14,000 attendees and 750 ... in such areas as digestive health, heart health, healthy ... Nutrition’s booth will feature its world leading Epax® brand ...
(Date:4/27/2015)... (PRWEB) April 27, 2015 On May ... conclude a social media campaign to raise awareness of ... Michael Mamas; and Sri Somesvara Temple. Ironically, when many ... of North Carolina, they thought they were leaving the ... at least six months of meditation, service to a ...
Breaking Medicine News(10 mins):Health News:Dentist in Graham NC Reveals that a Jaw Disorder May Be the Cause of Chronic Headaches and Back Pain 2Health News:Six Additional New ISO 27001 Lead Implementers Certified for Pivot Point Security 2Health News:Guiding Principles for Patient Experience Excellence Identified by The Beryl Institute 2Health News:FMC Health and Nutrition to Feature Epax® Brand Omega-3 Ingredients at Vitafoods Europe 2015 2Health News:Mount Soma Monks Do Social Media 2
... Scientists seeking to harness the power of the ... hurdles: recruiting key immune cells called dendritic cells into ... found and helping them recognize tumor cells as targets ... however, have identified a sequence of molecular events that ...
... Tracey Neale, MC,s event with Rock & Roll Hall ... the nation,s biggest problem: the health of our peopleWASHINGTON, ... Inaugural Ball announced today the complete line up of ... Natural History Museum, home of the Hope Diamond. ...
... Ohio distributor recalls two King Nut brands; almost 400 in ... -- Lab tests on a tainted tub of peanut butter ... has sickened almost 400 people across the United States, Minnesota ... the Minnesota Department of Health Web site, was a follow-up ...
... The Academy of Breastfeeding Medicine feels ... be well advised to review its policy banning photographs ... that breastfeeding is an unseemly bodily function best kept ... has no place in contemporary society. It further perpetuates ...
... to consumers and purchasers , PHILADELPHIA, Jan. 12 ... awarded full accreditation in Pharmacy Benefit Management from ... that establishes quality standards for the health care ... symbol of excellence to employers, health care consumers, ...
... County Community College,District (WCCCD) has partnered with the Michigan ... oral health for foster care youth. The seminar,will be ... Student Welcome,Center on Wednesday, January 14, at 2:00 p.m. ... of the District,s Dental Program will schedule,teeth cleaning appointments ...
Cached Medicine News:Health News:Gene therapy eliminates brain tumors through selective recruitment of immune cells 2Health News:Gene therapy eliminates brain tumors through selective recruitment of immune cells 3Health News:Health for All Inaugural Ball Brings Renowned Speakers and Entertainment to Election's Key Issue 2Health News:Health for All Inaugural Ball Brings Renowned Speakers and Entertainment to Election's Key Issue 3Health News:Minn. Confirms Tainted Peanut Butter Link to Salmonella Outbreak 2Health News:Facebook Flack Regarding Breastfeeding Mothers 2Health News:FutureScripts(R) Earns URAC Pharmacy Benefit Manager Accreditation 2Health News:WCCCD Partners With Michigan Department of Human Services to Present a Dental Health Seminar to Foster Care Youth 2
(Date:4/27/2015)... , April 27, 2015  As the Innovation Insight ... Philadelphia , InCrowd, provider of on-demand answers ... of life science insights experts in charting a new ... and innovation in research. Presented jointly by ... by Communispace Health, IIeX Health features TED-style presentations and ...
(Date:4/27/2015)... 2015 - The First Company in ... State Intellectual Property Office of China ... - A New Treatment Which Offers Hope for ... - About 20% of Elderly Urban Chinese Suffer From Peripheral ... Higher Than in Men. CLI is a Progressive Form of ...
(Date:4/26/2015)... , April 26, 2015 Cancer experts ... VAR ) supported project in the area of distributed ... data" for the benefit of patients. Speakers at a ... Society for Therapeutic Radiation Oncology) forum in Barcelona ... treatment and applying that knowledge to help benefit the ...
Breaking Medicine Technology:InCrowd Helps IIeX Health 2015 Chart New Paths for Turning Physician Insights Into Innovation 2InCrowd Helps IIeX Health 2015 Chart New Paths for Turning Physician Insights Into Innovation 3Stempeutics Gets Stem Cell Patent in China (Chinese Application Number: CN201080053627) for its Novel Stem Cell Drug 'Stempeucel' 2Stempeutics Gets Stem Cell Patent in China (Chinese Application Number: CN201080053627) for its Novel Stem Cell Drug 'Stempeucel' 3Stempeutics Gets Stem Cell Patent in China (Chinese Application Number: CN201080053627) for its Novel Stem Cell Drug 'Stempeucel' 4Cancer Experts Detail How 'Big Data' Plays a Critical Role in Improving Clinical Decision-Making in Oncology Treatments at 3rd ESTRO Forum 2Cancer Experts Detail How 'Big Data' Plays a Critical Role in Improving Clinical Decision-Making in Oncology Treatments at 3rd ESTRO Forum 3
... 17, 2012 SynCardia Systems, Inc. ( www.syncardia.com ), ... Canada and CE (Europe) approved Total Artificial Heart, announced ... due in part to Certified Centers performing a record ... Artificial Heart . (Photo: http://photos.prnewswire.com/prnh/20120517/LA08709 ...
... SAN FRANCISCO, May 17, 2012  Varian Medical Systems (NYSE: ... treating early-stage inoperable lung cancer and other conditions non-invasively ... Society (ATS) later this week in San Francisco.  ... front of pulmonologists who may not be familiar with ...
Cached Medicine Technology:SynCardia Posts Record Revenue and Profit in Q1 2012 2SynCardia Posts Record Revenue and Profit in Q1 2012 3Varian Medical Systems to Showcase Radiosurgery Technology for Non-invasive Treatment of Early Stage Inoperable Lung Cancer 2Varian Medical Systems to Showcase Radiosurgery Technology for Non-invasive Treatment of Early Stage Inoperable Lung Cancer 3Varian Medical Systems to Showcase Radiosurgery Technology for Non-invasive Treatment of Early Stage Inoperable Lung Cancer 4
TVL defibrillation leads have a patented coiled-coil design for faster, easier insertion and more precise intracardiac placement. Designed with an integrated bipolar design, the lead enables high-vol...
The Livewire steerable electrophysiology catheter is uniquely designed with an ergonomic handle and patented steering mechanism to provide smooth, precise catheter tip movement, even during lengthy e...
... HP catheters feature 20 bipolar-spaced electrodes ... highest degree of mapping resolution in ... via a 20-pole catheter enables more ... than with 10-pole catheter systems. The ...
Livewire TC steerable ablation catheters are designed for the RF ablation of arrhythmias. They are available in a variety of curves and configurations, including bi-directional catheters for added fl...
Medicine Products: