Navigation Links
MIPT scientists develop algorithm for anti-aging remedy search
Date:5/15/2014

The scientists Alexander Zhavoronkov, Anton Buzdin, Andrey Garazha, Nickolay Borisov and Alexey Moskalev have based the new research on their previously-developed methods in the study of cancer cells. Each cell uses particular schemes of molecular interaction, which physiologists call intercellular signaling pathways.

A signaling pathway is a chain of sequential events of interaction between certain molecules which make the cell respond to stimulation. For example, hormone molecules first interact with the cell's membrane receptors, then the receptors engage with the molecules inside the cell, and those, in turn, deliver the signal into the cell's nucleus. As a result, inside the nucleus there occur changes in the way certain proteins engage with DNA and in the expression of genes. This leads to changes in the synthesis of RNA molecules, which are responsible for protein-producing processes.

Events in a cell's life-cycle can be roughly of two types: normal (such as hormone-induced response or performance of certain functions related to body growth) and abnormal, or pathological (i.e., malignant degeneration). Both these types of events are accompanied by changes in signaling pathway activity. What is more important, the same chain of reactions can be traced in totally different processes, i.e., there is no such thing as a "malignant cell forming protein", or a "long-term memory protein".

The team of experts from MIPT and other Russian and British organizations (the full list of names can be found in the article) suggested comparing peculiarities of signaling pathways activation in young and aging cells. This information is then expanded with the available data on the impact of various substances on signaling pathways.

Thus, the new algorithm helps to predict the type of change in the profile of intracellular molecular interaction which will occur in response to this or that drug.

In their article the scientists point out that their algorithm can be used in rapid and inexpensive search for drugs which can minimize the difference between the cells of young and elderly patients. This means that it will be possible to speed up the search for longevity drugs and decrease its cost. What is more, this will be achieved not by simply fighting some particular diseases, but by a complex influence on the mechanisms of aging.


'/>"/>

Contact: Alexandra O. Borissova
borisova.ao@mipt.ru
7-926-376-1175
Moscow Institute of Physics and Technology
Source:Eurekalert

Related medicine news :

1. Scientists reveal structural secrets of enzyme used to make popular anti-cholesterol drug
2. Scientists slow brain tumor growth in mice
3. UBC scientists find new way to mobilize immune system against viruses
4. Dartmouth scientists identify genetic blueprint for cancerous tumors of the appendix
5. Scientists decode epigenetic mechanisms distinguishing stem cell function and blood cancer
6. Scientists identify new protein in the neurological disorder dystonia
7. Scientists awarded grant to develop diagnostics for cancer, rheumatoid arthritis, colitis
8. Norwegian neuroscientists elected to National Academy of Sciences
9. NIH scientists establish monkey model of hantavirus disease
10. Stanford scientists create circuit board modeled on the human brain
11. A civil war inside our cells: Scientists show how our bodies fight off jumping genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... ... May 26, 2017 , ... The ... seminar to focus on current legislative activity and the latest regulatory concerns impacting ... p.m. Sunday, Sept. 10, and will continue through Monday, Sept. 11, at the ...
(Date:5/26/2017)... Sparks, Nevada (PRWEB) , ... May 26, 2017 ... ... to produce the first ever copper, antimicrobial, mesh back 24/7 task chair specifically ... and conference applications. “We are thrilled to partner with Cupron® to provide ...
(Date:5/26/2017)... , ... May 26, 2017 , ... Rob Lowe acts ... upcoming production of the series is on hiking in American. Viewers can reconnect with ... the great benefits of hiking. , Many consumers have looked for an inventive new ...
(Date:5/26/2017)... ... ... Happened in the Garden of Eden”: retells the stories of three Bible figures in modern ... author, Penelope Colt, mother, trader, horse farmer, artist and a former GM journeyman. Born ... At six, they moved to Dayton, Ohio, where Penny graduated high school. At sixteen, ...
(Date:5/24/2017)... York, New York (PRWEB) , ... May 24, 2017 , ... ... general vascular surgery in New York City. He is known for his ... broad specialization in vascular surgery, Dr. Benvenisty holds sub-specialty training in treating renovascular disease ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)... , May 9, 2017  Demonstrating its ... board of directors for the Pharmaceutical Research and ... for membership. Biopharmaceutical companies will now have to ... order to be eligible to join PhRMA. ... the board is sending a clear message that ...
(Date:5/8/2017)... , May 8, 2017 MACRA ... transition from fee for service reimbursement. Black Book Research ... 1.       The Market for MIPS Compliance ... 77% of physician practices with 3 or more clinicians ... Solutions by Q4. "Given the magnitude of the changes, ...
(Date:5/6/2017)... 5, 2017  May is Stroke Awareness Month and ... most important methods to prevent a stroke: monitor and ... Disease Control and Prevention, undetected and uncontrolled hypertension is ... the global leader in personal heart health technology, recently ... heart attack and stroke and is advancing a national ...
Breaking Medicine Technology: