Navigation Links
MIPT scientists develop algorithm for anti-aging remedy search
Date:5/15/2014

The scientists Alexander Zhavoronkov, Anton Buzdin, Andrey Garazha, Nickolay Borisov and Alexey Moskalev have based the new research on their previously-developed methods in the study of cancer cells. Each cell uses particular schemes of molecular interaction, which physiologists call intercellular signaling pathways.

A signaling pathway is a chain of sequential events of interaction between certain molecules which make the cell respond to stimulation. For example, hormone molecules first interact with the cell's membrane receptors, then the receptors engage with the molecules inside the cell, and those, in turn, deliver the signal into the cell's nucleus. As a result, inside the nucleus there occur changes in the way certain proteins engage with DNA and in the expression of genes. This leads to changes in the synthesis of RNA molecules, which are responsible for protein-producing processes.

Events in a cell's life-cycle can be roughly of two types: normal (such as hormone-induced response or performance of certain functions related to body growth) and abnormal, or pathological (i.e., malignant degeneration). Both these types of events are accompanied by changes in signaling pathway activity. What is more important, the same chain of reactions can be traced in totally different processes, i.e., there is no such thing as a "malignant cell forming protein", or a "long-term memory protein".

The team of experts from MIPT and other Russian and British organizations (the full list of names can be found in the article) suggested comparing peculiarities of signaling pathways activation in young and aging cells. This information is then expanded with the available data on the impact of various substances on signaling pathways.

Thus, the new algorithm helps to predict the type of change in the profile of intracellular molecular interaction which will occur in response to this or that drug.

In their article the scientists point out that their algorithm can be used in rapid and inexpensive search for drugs which can minimize the difference between the cells of young and elderly patients. This means that it will be possible to speed up the search for longevity drugs and decrease its cost. What is more, this will be achieved not by simply fighting some particular diseases, but by a complex influence on the mechanisms of aging.


'/>"/>

Contact: Alexandra O. Borissova
borisova.ao@mipt.ru
7-926-376-1175
Moscow Institute of Physics and Technology
Source:Eurekalert

Related medicine news :

1. Scientists reveal structural secrets of enzyme used to make popular anti-cholesterol drug
2. Scientists slow brain tumor growth in mice
3. UBC scientists find new way to mobilize immune system against viruses
4. Dartmouth scientists identify genetic blueprint for cancerous tumors of the appendix
5. Scientists decode epigenetic mechanisms distinguishing stem cell function and blood cancer
6. Scientists identify new protein in the neurological disorder dystonia
7. Scientists awarded grant to develop diagnostics for cancer, rheumatoid arthritis, colitis
8. Norwegian neuroscientists elected to National Academy of Sciences
9. NIH scientists establish monkey model of hantavirus disease
10. Stanford scientists create circuit board modeled on the human brain
11. A civil war inside our cells: Scientists show how our bodies fight off jumping genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery ... of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , ... for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey ...
(Date:6/25/2016)... Beach, CA (PRWEB) , ... June 25, 2016 , ... ... UCLA with Magna Cum Laude and his M.D from the David Geffen School of ... Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at the ...
(Date:6/24/2016)... ... ... A recent article published June 14 on E Online details ... to state that individuals are now more comfortable seeking to undergo not only the ... and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) notes ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Conference and Scientific Sessions in Dallas that it will receive two significant new ... the grants came as PHA marked its 25th anniversary by recognizing patients, medical ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief ... a minimum wage raise to $12 an hour by 2020 and then adjusting it yearly ... lost value of the minimum wage, assure the wage floor does not erode again, and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Belgium , June 24, 2016 ... today announced the appointment of Dr. Edward ... as a Non-Executive Director, effective June 23, 2016.Dr. ... Compensation and Nominations and Governance Committees.  As a ... will provide independent expertise and strategic counsel to ...
(Date:6/23/2016)... June 23, 2016 Research and ... Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), ... Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is projected ... CAGR of 6.1% in the forecast period 2016 to ...
(Date:6/23/2016)... 2016 Research and Markets has announced ... report to their offering. ... a favourable commercial environment for MedImmune to enter. The US ... will serve to drive considerable growth for effective anti-influenza medications. ... cap sales considerably, but development is still in its infancy. ...
Breaking Medicine Technology: