Navigation Links
MIPT scientists develop algorithm for anti-aging remedy search
Date:5/15/2014

The scientists Alexander Zhavoronkov, Anton Buzdin, Andrey Garazha, Nickolay Borisov and Alexey Moskalev have based the new research on their previously-developed methods in the study of cancer cells. Each cell uses particular schemes of molecular interaction, which physiologists call intercellular signaling pathways.

A signaling pathway is a chain of sequential events of interaction between certain molecules which make the cell respond to stimulation. For example, hormone molecules first interact with the cell's membrane receptors, then the receptors engage with the molecules inside the cell, and those, in turn, deliver the signal into the cell's nucleus. As a result, inside the nucleus there occur changes in the way certain proteins engage with DNA and in the expression of genes. This leads to changes in the synthesis of RNA molecules, which are responsible for protein-producing processes.

Events in a cell's life-cycle can be roughly of two types: normal (such as hormone-induced response or performance of certain functions related to body growth) and abnormal, or pathological (i.e., malignant degeneration). Both these types of events are accompanied by changes in signaling pathway activity. What is more important, the same chain of reactions can be traced in totally different processes, i.e., there is no such thing as a "malignant cell forming protein", or a "long-term memory protein".

The team of experts from MIPT and other Russian and British organizations (the full list of names can be found in the article) suggested comparing peculiarities of signaling pathways activation in young and aging cells. This information is then expanded with the available data on the impact of various substances on signaling pathways.

Thus, the new algorithm helps to predict the type of change in the profile of intracellular molecular interaction which will occur in response to this or that drug.

In their article the scientists point out that their algorithm can be used in rapid and inexpensive search for drugs which can minimize the difference between the cells of young and elderly patients. This means that it will be possible to speed up the search for longevity drugs and decrease its cost. What is more, this will be achieved not by simply fighting some particular diseases, but by a complex influence on the mechanisms of aging.


'/>"/>

Contact: Alexandra O. Borissova
borisova.ao@mipt.ru
7-926-376-1175
Moscow Institute of Physics and Technology
Source:Eurekalert

Related medicine news :

1. Scientists reveal structural secrets of enzyme used to make popular anti-cholesterol drug
2. Scientists slow brain tumor growth in mice
3. UBC scientists find new way to mobilize immune system against viruses
4. Dartmouth scientists identify genetic blueprint for cancerous tumors of the appendix
5. Scientists decode epigenetic mechanisms distinguishing stem cell function and blood cancer
6. Scientists identify new protein in the neurological disorder dystonia
7. Scientists awarded grant to develop diagnostics for cancer, rheumatoid arthritis, colitis
8. Norwegian neuroscientists elected to National Academy of Sciences
9. NIH scientists establish monkey model of hantavirus disease
10. Stanford scientists create circuit board modeled on the human brain
11. A civil war inside our cells: Scientists show how our bodies fight off jumping genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2017)... KS (PRWEB) , ... September 22, 2017 , ... ... Plus, a nutritional supplement produced by Native Remedies that helps promote pancreatic health ... priority for many individuals. However, some prescription-based approaches can have negative side effects, ...
(Date:9/22/2017)... , ... September 22, 2017 , ... “Letters From Home”: ... people, even the lost, have value to God. “Letters From Home” is the creation ... a member of the President’s Cabinet of Jerry Savelle Ministries International, who has traveled ...
(Date:9/21/2017)... ... ... 38-Year-Old Plastic Surgeon Gill at Aesthetic Surgery Center is Saluted as Young Achiever ... Surgeon Kiranjeet Gill has been awarded as one of the 15th annual 40-under-40 recipients! ... started in 2003 to salute young achievers in Southwest Florida who have distinguished themselves ...
(Date:9/21/2017)... ... September 21, 2017 , ... Hair restoration surgery ... survey conducted by the International Society of Hair Restoration Surgery (ISHRS). ... rose 60 percent, with 635,189 procedures performed in 2016. , "Like other ...
(Date:9/21/2017)... ... 2017 , ... The New England Center for Children® (NECC®), a global leader ... Hung to the Board of Directors. , “The New England Center for Children ... an invaluable addition to our team,” said Vincent Strully, Jr., President and CEO of ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... -- As the latest Obamacare repeal effort moves is debated, ... and Lindsey Graham (R-SC) medical device market ... is in an odd place.  The industry wants repeal ... on medical device sales passed along with the Affordable ... visits and hospital customers with the funding to invest ...
(Date:9/19/2017)... , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing a ... targeted tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek , ...
(Date:9/18/2017)... , Sept. 18, 2017  PMD Healthcare of ... Pharmacy of Kalamazoo, Mich. , have ... service that expedites and streamlines patient and provider access ... 2.0, and wellness management services.  ... used to measure lung function for a variety of ...
Breaking Medicine Technology: